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公开(公告)号：US11697028B2
公开(公告)日：2023-07-11
申请号：US17942353
申请日：2022-09-12
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Thomas Boyajian , Mark Carota , Brian Mazejka
CPC classification number: A61N5/062 , A61B5/0064 , A61B5/0082 , A61N2005/0626 , A61N2005/0633 , A61N2005/0642 , A61N2005/0651 , A61N2005/0652 , A61N2005/0662 , A61N2005/0663
Abstract: An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of first panels or the at least one second panel and configured to irradiate the surface with substantially uniform intensity visible light. The plurality of first panels and the at least one second panel are rotatably connected. The at least one second panel is connected on each side to one of the plurality of first panels. The second panel acts as a “lighted hinge” to reduce or eliminate optical dead spaces between adjacent panels when the illuminator is bent into a certain configuration.
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公开(公告)号：US11690914B2
公开(公告)日：2023-07-04
申请号：US17876224
申请日：2022-07-28
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Scott Lundahl , Michael Guttadauro
CPC classification number: A61K41/0061 , A61K9/0014 , A61K9/08 , A61K31/75 , A61K47/10 , A61N5/062 , A61P17/12 , A61N2005/0633 , A61N2005/0642 , A61N2005/0652 , A61N2005/0659 , A61N2005/0663
Abstract: A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
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公开(公告)号：US11571478B2
公开(公告)日：2023-02-07
申请号：US17487698
申请日：2021-09-28
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Scott Lundahl , Michael Guttadauro
Abstract: A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
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公开(公告)号：US11446512B2
公开(公告)日：2022-09-20
申请号：US16791004
申请日：2020-02-14
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Thomas Boyajian , Mark Carota , Brian Mazejka
Abstract: An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of first panels or the at least one second panel and configured to irradiate the surface with substantially uniform intensity visible light. The plurality of first panels and the at least one second panel are rotatably connected. The at least one second panel is connected on each side to one of the plurality of first panels. The second panel acts as a “lighted hinge” to reduce or eliminate optical dead spaces between adjacent panels when the illuminator is bent into a certain configuration.
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公开(公告)号：US20210001101A1
公开(公告)日：2021-01-07
申请号：US17027872
申请日：2020-09-22
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Thomas BOYAJIAN , Mark CAROTA
Abstract: An applicator for dispensing a solution having two or more components includes a hollow body having a head provided at one end of the hollow body for dispersion of the solution and a breaking mechanism attached to the hollow body. The breaking mechanism includes at least one projection extendable into an interior of the hollow body. The applicator further includes a plurality of ampoules placed in the interior of the hollow body. The plurality of ampoules contains the two or more components. Upon activation of the breaking mechanism, the at least one projection applies a force to the plurality of ampoules such that the plurality of ampoules break and release the two or more components to form the solution.
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Patent Agency Ranking
公开(公告)号：US20190216927A1
公开(公告)日：2019-07-18
申请号：US15869164
申请日：2018-01-12
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Scott LUNDAHL , Michael Guttadauro
CPC classification number: A61K41/0061 , A61K9/0014 , A61K31/75 , A61N5/062 , A61N2005/0652 , A61N2005/0659 , A61N2005/0663 , A61P17/12
Abstract: A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
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7.发明授权公开(公告)号：US09241957B2
公开(公告)日：2016-01-26
申请号：US14088711
申请日：2013-11-25
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Scott Lundahl , Stuart Marcus
IPC: A61K41/00 , A61K33/26 , A61K31/198 , A61K31/409 , A61N5/06
CPC classification number: A61K33/26 , A61K31/409 , A61K41/0061 , A61K41/0071 , A61N5/062 , A61K2300/00 , A61K41/0057
Abstract: The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin complexing molecules as agents for reducing photosensitivity.
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公开(公告)号：US20150105667A1
公开(公告)日：2015-04-16
申请号：US14282636
申请日：2014-05-20
Applicant: DUSA Pharmaceuticals, Inc.
Inventor： Scott LUNDAHL , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
CPC classification number: A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
Abstract: An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
Abstract translation: 一种用于光动力学治疗或光动力学诊断的装置和方法，其使用照明器，所述照明器包括通常符合轮廓表面的多个光源，并且以基本均匀的强度可见光照射所述轮廓表面。 光源可以包括由电子镇流器驱动的大致U形荧光管。 改变U形管的间距以增加照明器边缘处的输出，使得输出更均匀。 而且，不同部分的管以不同的量被冷却，以提高均匀性。 光传感器监测来自U形管的输出，以提供用于调节管的输出的信号。
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公开(公告)号：US20100191172A1
公开(公告)日：2010-07-29
申请号：US12621845
申请日：2009-11-19
Applicant: Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
Inventor： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
IPC: A61N5/00
CPC classification number: A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
Abstract: An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
Abstract translation: 一种用于光动力学治疗或光动力学诊断的装置和方法，其使用照明器，所述照明器包括通常符合轮廓表面的多个光源，并且以基本均匀的强度可见光照射所述轮廓表面。 光源可以包括由电子镇流器驱动的大致U形荧光管。 镇流器电压的调节控制管的输出功率。 管由金属板或塑料外壳支撑，并被聚碳酸酯防护罩覆盖，聚碳酸酯防护罩可引导设备内的冷却气流，并防止玻璃 - 患者接触管道破裂。 位于管后面的铝反射器增加了输出辐照度和输出分布的均匀性。 改变U形管的间距以增加照明器边缘处的输出，使得输出更均匀。 而且，不同部分的管以不同的量被冷却，以提高均匀性。 光传感器监测来自U形管的输出，以提供用于调节管的输出的信号。
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公开(公告)号：US07190109B2
公开(公告)日：2007-03-13
申请号：US10755318
申请日：2004-01-13
Applicant: Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
Inventor： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
CPC classification number: A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
Abstract: An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the event of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
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