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    Self-cleaning fluid delivery device for medical applications
    2.
    发明授权
    Self-cleaning fluid delivery device for medical applications 有权
    用于医疗应用的自清洁流体输送装置

    公开(公告)号：US06860870B2

    公开(公告)日：2005-03-01

    申请号：US10034836

    申请日：2001-12-21

    申请人： Dean M. Pichon ,  David J. Nedder ,  John R. Sousa ,  J. Jeffrey Kablik ,  Albert H. Linder

    发明人： Dean M. Pichon ,  David J. Nedder ,  John R. Sousa ,  J. Jeffrey Kablik ,  Albert H. Linder

    IPC分类号： A61B17/00 ,  B05B7/06 ,  A61M5/00

    CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00544 ,  B05B7/066

    摘要： A gas powered spraying device that can be used for single or multi-part reactive medical polymer compositions is provided. A fluid or one or more reactive solutions are sprayed independently at a tissue surface, and the spraying of each solution of multi-component embodiments is controlled by a separate valve. Each solution is provided with a separate spray outlet, and each spray outlet is surrounded by an annular sheath of flowing gas. Gas flow is provided at two or more flow levels, including a high level flow for active spraying and a low level bypass flow to remove drips and prevent clogging, which can improve device reliability. Gas pressure can be used to drive fluid to its spray outlet, as well as to spray the fluid from the outlet to the tissue surface.

    摘要翻译： 提供了可用于单组分或多部分反应性医用聚合物组合物的燃气动力喷涂装置。 流体或一种或多种反应性溶液在组织表面独立喷雾，并且多组分实施方案的每种溶液的喷雾由单独的阀控制。 每个溶液都设置有单独的喷雾出口，并且每个喷雾出口被流动气体的环形护套包围。 气流以两个或多个流量水平提供，包括用于主动喷射的高水平流量和用于去除滴液并防止堵塞的低水平旁路流动，这可以提高装置的可靠性。 气体压力可用于将流体驱动到其喷射出口，以及将流体从出口喷射到组织表面。

    Compliant tissue sealants
    7.
    发明申请
    Compliant tissue sealants 有权
    符合组织密封剂

    公开(公告)号：US20040234574A9

    公开(公告)日：2004-11-25

    申请号：US10338933

    申请日：2003-01-07

    申请人： Focal, Inc.

    发明人： Amarpreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

    IPC分类号： A61F002/00

    CPC分类号： A61L31/06 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  C08L67/04

    摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

    摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 在优选实施例中，该系统是符合的，因为当组织在愈合过程中弯曲并变形时，其能够符合组织表面的三维结构。 通过将可聚合单体施加到表面上，然后聚合单体，将屏障或药物递送系统形成为组织表面上的聚合物涂层。 聚合的柔顺涂层优选是可生物降解和生物相容的，并且可以设计成具有选择的适应性和弹性性质，用于不同的手术和治疗应用。

    Apparatus and method for local application of polymeric material to tissue
    8.
    发明申请
    Apparatus and method for local application of polymeric material to tissue 失效
    将聚合物材料局部应用于组织的装置和方法

    公开(公告)号：US20040131554A1

    公开(公告)日：2004-07-08

    申请号：US10664582

    申请日：2003-09-17

    申请人： Focal, Inc.

    发明人： Stephen C. Rowe ,  Jeffrey A. Hubbell ,  Stephen J. Herman ,  Vae Sun ,  Michael F. Lang ,  George E. Selecman ,  Frederick F. Ahari

    IPC分类号： A61L009/04

    CPC分类号： A61B1/00165 ,  A61B17/00491 ,  A61B2017/005 ,  A61B2090/0816 ,  A61C19/004 ,  A61M37/00 ,  B05C17/01

    摘要： An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practiced in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

    摘要翻译： 提供了一种装置，用于向哺乳动物组织的表面施加包括软的活体组织的初始流畅的材料，然后通过暴露于能量源来激活材料。 该材料可以是能够通过暴露于光化光聚合成非流动状态的液体。 可以与装置相关联地实施的装置和方法使得能够治疗的广泛的医疗状况包括例如对软组织的屏障的应用以防止手术后粘连。

    Compliant tissue sealants
    9.
    发明申请
    Compliant tissue sealants 有权
    符合组织密封剂

    公开(公告)号：US20020127266A1

    公开(公告)日：2002-09-12

    申请号：US10053356

    申请日：2001-11-07

    申请人： Focal, Inc.

    发明人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

    IPC分类号： A61F002/00

    CPC分类号： A61L31/06 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  C08L67/04

    摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

    摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 在优选实施例中，该系统是符合的，因为当组织在愈合过程中弯曲并变形时，其能够符合组织表面的三维结构。 通过将可聚合单体施加到表面上，然后聚合单体，将屏障或药物递送系统形成为组织表面上的聚合物涂层。 聚合的柔顺涂层优选是可生物降解和生物相容的，并且可以设计成具有选择的适应性和弹性性质，用于不同的手术和治疗应用。