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公开(公告)号：US20110144393A1
公开(公告)日：2011-06-16
申请号：US12997063
申请日：2009-06-05
申请人： Sean Dennis Simpson , Phuong Loan Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , Fungmin Liew
发明人： Sean Dennis Simpson , Phuong Loan Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , Fungmin Liew
摘要： The invention provides methods for producing 2,3-butanediol by anaerobic fermentation. According to particular methods of the invention, 2,3-butanediol is produced by anaerobic fermentation of substrates including carbohydrate and carbon monoxide.
摘要翻译： 本发明提供了通过厌氧发酵生产2,3-丁二醇的方法。 根据本发明的具体方法，2,3-丁二醇通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生。
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公开(公告)号：US09550979B2
公开(公告)日：2017-01-24
申请号：US13857375
申请日：2013-04-05
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12Y101/01001 , C12Y101/01002 , Y02E50/17
摘要： The present invention relates to mutant alcohol dehydrogenase enzymes, microorganisms comprising the mutant alcohol dehydrogenase enzymes, and methods for the production of products by microbial fermentation using the microorganisms.
摘要翻译： 本发明涉及突变型醇脱氢酶，包含突变型醇脱氢酶的微生物，以及使用微生物通过微生物发酵生产产物的方法。
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公开(公告)号：US20110275053A1
公开(公告)日：2011-11-10
申请号：US13058629
申请日：2010-01-29
摘要： The invention relates to the production of products such as alcohols and acids by microbial fermentation, particularly microbial fermentation of substrates comprising CO. It more particularly relates to methods and systems for improving efficiency of products by microbial fermentation. In particular embodiments, the invention provides a method of optimising production of desired products including the step of ascertaining the proportion of CO converted to CO2.
摘要翻译： 本发明涉及通过微生物发酵，特别是包含CO的底物的微生物发酵来生产诸如醇和酸的产品，更具体地涉及通过微生物发酵提高产品效率的方法和系统。 在具体实施方案中，本发明提供了优化所需产物生产的方法，包括确定转化为CO 2的CO的比例的步骤。
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公开(公告)号：US20110250629A1
公开(公告)日：2011-10-13
申请号：US13060357
申请日：2010-12-23
摘要： The invention relates to the microbial fermentation of gaseous substrates, particularly to methods of mitigating and/or reducing alcohol toxicity effects on a microbial culture at elevated alcohol concentrations during fermentation. The invention relates particularly to microbial fermentation of substrates comprising CO and the effects of alcohol toxicity are reduced or mitigated by maintaining the temperature below the optimum operating temperature by cooling the fermentation broth.
摘要翻译： 本发明涉及气态底物的微生物发酵，特别是涉及在发酵过程中在升高的醇浓度下减轻和/或降低酒精毒性对微生物培养物的影响的方法。 本发明特别涉及包含CO的底物的微生物发酵，并且通过冷却发酵液将温度保持在最佳操作温度以下，可降低或减轻酒精毒性的影响。
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公开(公告)号：US20110294177A1
公开(公告)日：2011-12-01
申请号：US13058375
申请日：2009-11-30
摘要： The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of substrates comprising CO. It more particularly relates to the provision of an improved fermentation media, comprising nickel, to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to one or more alcohols, such as ethanol. In particular embodiments, a microbial culture is provided with at least 10 μM nickel, such that CO uptake by the microbial culture increases and ethanol productivity improves.
摘要翻译： 本发明涉及通过微生物发酵，特别是通过微生物发酵包含CO的底物生产醇的方法的改进。更具体地说，涉及向发酵系统提供包含镍的改进发酵培养基，使得一 或更多的微生物将包含CO的底物转化成一种或多种醇，例如乙醇。 在具体实施方案中，向微生物培养物提供至少10μM的镍，使得通过微生物培养物吸收的CO增加，乙醇生产率提高。
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公开(公告)号：US20110269197A1
公开(公告)日：2011-11-03
申请号：US13119582
申请日：2011-01-14
摘要： The invention relates to methods for improving the efficiency of carbon capture in microbial fermentation of a gaseous substrate comprising CO and/or H2. In certain aspects the invention relates to improving the efficiency of carbon capture in the microbial fermentation of gaseous substrate comprising CO and/or H2 to produce alcohol(s) and/or acid(s). In particular the invention relates to methods for improving the efficiency of carbon capture in carboxydotrophic fermentation.
摘要翻译： 本发明涉及用于提高包含CO和/或H2的气态底物的微生物发酵中碳捕集效率的方法。 在某些方面，本发明涉及提高包含CO和/或H 2的气态底物的微生物发酵中的碳捕获效率以产生醇和/或酸。 特别地，本发明涉及用于提高羧基营养发酵中碳捕获效率的方法。
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公开(公告)号：US20130203143A1
公开(公告)日：2013-08-08
申请号：US13879605
申请日：2011-10-28
IPC分类号： C12P5/00
CPC分类号： C12P5/00 , C10G2/32 , C10G2400/02 , C10G2400/04 , C10G2400/08 , C10K1/024 , C10K1/32 , C10K3/026 , C12M21/12 , C12M43/00 , C12P7/065 , C12P7/08 , C12P7/16 , C12P7/18 , Y02E50/10 , Y02E50/13 , Y02E50/17 , Y02E50/343 , Y02P20/132 , Y02P20/146
摘要： Methods and systems for the production of hydrocarbon products, including providing a substrate comprising CO to a bioreactor containing a culture of one or more micro-organisms; and fermenting the culture in the bioreactor to produce one or more hydrocarbon products. The substrate comprising CO is derived from a CO2 reforming process.
摘要翻译： 用于生产烃产品的方法和系统，包括向含有一种或多种微生物培养物的生物反应器提供包含CO的底物; 并在生物反应器中发酵培养物以产生一种或多种烃产物。 包含CO的底物来自CO 2重整过程。
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公开(公告)号：US08178330B2
公开(公告)日：2012-05-15
申请号：US13058727
申请日：2010-09-03
IPC分类号： C12P7/06
CPC分类号： C12P7/54 , C12M21/12 , C12M29/04 , C12M29/18 , C12M29/24 , C12P7/065 , C12P7/08 , Y02E50/17 , Y02E50/343
摘要： The invention relates to the microbial fermentation of gaseous substrates, particularly to gas/liquid contact modules and bioreactors configured to improve the efficiency of fermentations, particularly microbial fermentations of substrates comprising CO. In a particular embodiment, a gas/liquid contact module with multiple channels is configured to produce products in a liquid fermentation broth. In a further particular embodiment, there is provided a method of fermentation of a gaseous substrate to produce a product in a liquid fermentation broth.
摘要翻译： 本发明涉及气态底物的微生物发酵，特别是气体/液体接触模块和生物反应器的微生物发酵，其被配置为提高发酵效率，特别是包含CO的底物的微生物发酵。在具体实施方案中，具有多个通道的气/液接触模块 被配置为在液体发酵液中产生产物。 在另一个具体实施方案中，提供了一种发酵气态底物以在液体发酵液中产生产物的方法。
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公开(公告)号：US08658415B2
公开(公告)日：2014-02-25
申请号：US13684215
申请日：2012-11-22
CPC分类号： C12Q3/00 , C12N1/04 , C12N1/20 , C12P7/06 , C12P7/065 , C12P7/16 , C12P7/40 , Y02E50/10 , Y02E50/17
摘要： The present invention relates to methods for sustaining a microbial culture during periods of limited substrate supply. In accordance with the methods of the invention, a microbial culture comprising carboxydotrophic bacteria can be sustained during periods of limited substrate supply by maintaining the temperature of the microbial culture at a temperature below an optimum operating temperature. Examples of periods of limited substrate supply include when the microbial culture is transported to a remote location or during time when it is stored.
摘要翻译： 本发明涉及在有限的基质供应期间维持微生物培养的方法。 根据本发明的方法，通过将微生物培养物的温度保持在低于最佳操作温度的温度下，包含羧基营养细菌的微生物培养物可以在有限的底物供应期间持续。 有限的底物供应周期的实例包括当将微生物培养物运送到远程位置或在其被储存的时间期间。
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公开(公告)号：US08658408B2
公开(公告)日：2014-02-25
申请号：US13777806
申请日：2013-02-26
发明人： Sean Dennis Simpson , Loan Phuong Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , FungMin Liew , Shane Fleming
IPC分类号： C12P5/00
摘要： The invention provides method for producing butanediol and specifically 2,3-butanediol by anaerobic fermentation of a gaseous substrate comprising CO by a culture of at least one micro-organism. In accordance with particular methods of the invention, 2,3-butanediol is produced by anaerobic fermentation of substrates including carbohydrates and carbon monoxide. The invention further provides for the up-regulation of a native 2,3-butanediol dehydrogenase gene in the at least one micro-organism. The 2,3-butanediol can be further converted to compounds such as butene(s), butadiene and methyl ethyl ketone. These compounds can be further converted to chemical products such as 2-butanol.
摘要翻译： 本发明提供了通过至少一种微生物的培养物通过包含CO的气态底物的厌氧发酵来生产丁二醇和特别是2,3-丁二醇的方法。 根据本发明的具体方法，2,3-丁二醇通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生。 本发明还提供了至少一种微生物中天然2,3-丁二醇脱氢酶基因的上调。 2,3-丁二醇可以进一步转化为化合物，如丁烯，丁二烯和甲基乙基酮。 这些化合物可以进一步转化成化学产物如2-丁醇。
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