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1.发明授权公开(公告)号：US08357776B2
公开(公告)日：2013-01-22
申请号：US11600820
申请日：2006-11-17
申请人： Kyoichi Kagawa , Chizuko Fukuhama
发明人： Kyoichi Kagawa , Chizuko Fukuhama
CPC分类号： A61K38/07 , A61K38/012
摘要： The present invention provides a composition (composition for suppressing re-elevation of cholesterol) that has the effects of suppressing re-elevation of cholesterol in patients with high cholesterol or pre-high cholesterol, and that can therefore be used to suppress re-elevation of cholesterol in those patients. The present invention also provides a composition which, due to the effects described above, can be used to prevent or treat conditions or diseases caused by high cholesterol due to cholesterol re-elevation, specifically hypercholesterolemia, arteriosclerosis and diseases and conditions stemming therefrom. The composition of this invention uses as an active component an edible protein hydrolysate, preferably a globin proteolysate or a peptide consisting of Val-Val-Tyr-Pro.
摘要翻译： 本发明提供了具有抑制高胆固醇或高胆固醇的患者胆固醇升高的作用的抑制胆固醇再升高的组合物（组合物），因此可以用于抑制胆固醇的再升高 那些患者胆固醇。 本发明还提供了一种由于上述效果可以用于预防或治疗由胆固醇升高引起的高胆固醇，特别是高胆固醇血症，动脉硬化以及由此产生的疾病和病症的组合物。 本发明的组合物使用可食性蛋白质水解物，优选珠蛋白蛋白水解物或由Val-Val-Tyr-Pro组成的肽作为活性成分。
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公开(公告)号：US20180360899A1
公开(公告)日：2018-12-20
申请号：US15780485
申请日：2016-12-02
申请人： MG PHARMA INC.
发明人： Shigetoshi OKUMURA , Yuka SASAKAWA
IPC分类号： A61K36/484 , A23L33/105 , A23L33/00 , A61K36/232 , A61P3/04
摘要： An object of the present invention is to provide a novel agent for maintaining healthy obesity. The present invention relates to agent for maintaining healthy obesity containing processed Glycyrrhizae radix and/or Angelica keiskei as an active ingredient.
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公开(公告)号：US08691949B2
公开(公告)日：2014-04-08
申请号：US13123784
申请日：2009-10-28
申请人： Kyoichi Kagawa , Chizuko Fukuhama , Chunning Tong , Yuka Sasakawa
发明人： Kyoichi Kagawa , Chizuko Fukuhama , Chunning Tong , Yuka Sasakawa
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K1/00 , A61P3/10 , A61P7/12 , A61P3/08 , A61K38/28 , A61K51/00
CPC分类号： A23K50/80 , A23F3/163 , A23K20/147 , A23K50/40 , A23L2/52 , A23L33/18 , A23V2002/00 , A61K38/00 , C07K5/101 , A23V2200/326 , A23V2200/328 , A23V2250/0618 , A23V2250/0628 , A23V2250/0642
摘要： The present invention provides a composition (a blood glucose increase inhibitor) that has an effect of lowering blood glucose level in a hyperglycemic patient and that is therefore used to reduce blood glucose level in the patient. The present invention further provides a composition that is used to prevent or treat diseases caused by hyperglycemia, in particular, diabetes and diabetic complications (a composition for preventing or treating diseases caused by hyperglycemia, an antidiabetic), based on the above-mentioned effect. A feature of the present invention is using a peptide consisting of the amino acid sequence of Leu-Ser-Glu-Leu as an active ingredient.
摘要翻译： 本发明提供了具有降低高血糖患者血糖水平的作用的组合物（血糖增加抑制剂），因此用于降低患者血糖水平。 本发明还提供了一种用于预防或治疗由高血糖引起的疾病，特别是糖尿病和糖尿病并发症（用于预防或治疗由高血糖引起的疾病，抗糖尿病）的组合物）的组合物。 本发明的一个特征是使用由Leu-Ser-Glu-Leu的氨基酸序列组成的肽作为活性成分。
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公开(公告)号：US20110201551A1
公开(公告)日：2011-08-18
申请号：US13123784
申请日：2009-10-28
申请人： Kyoichi Kagawa , Chizuko Fukuhama , Chunning Tong , Yuka Sasakawa
发明人： Kyoichi Kagawa , Chizuko Fukuhama , Chunning Tong , Yuka Sasakawa
CPC分类号： A23K50/80 , A23F3/163 , A23K20/147 , A23K50/40 , A23L2/52 , A23L33/18 , A23V2002/00 , A61K38/00 , C07K5/101 , A23V2200/326 , A23V2200/328 , A23V2250/0618 , A23V2250/0628 , A23V2250/0642
摘要： The present invention provides a composition (a blood glucose increase inhibitor) that has an effect of lowering blood glucose level in a hyperglycemic patient and that is therefore used to reduce blood glucose level in the patient. The present invention further provides a composition that is used to prevent or treat diseases caused by hyperglycemia, in particular, diabetes and diabetic complications (a composition for preventing or treating diseases caused by hyperglycemia, an antidiabetic), based on the above-mentioned effect. A feature of the present invention is using a peptide consisting of the amino acid sequence of Leu-Ser-Glu-Leu as an active ingredient.
摘要翻译： 本发明提供了具有降低高血糖患者血糖水平的作用的组合物（血糖增加抑制剂），因此用于降低患者血糖水平。 本发明还提供了一种用于预防或治疗由高血糖引起的疾病，特别是糖尿病和糖尿病并发症（用于预防或治疗由高血糖引起的疾病，抗糖尿病）的组合物）的组合物。 本发明的一个特征是使用由Leu-Ser-Glu-Leu的氨基酸序列组成的肽作为活性成分。
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5.发明申请公开(公告)号：US20070191282A1
公开(公告)日：2007-08-16
申请号：US11600820
申请日：2006-11-17
申请人： Kyoichi Kagawa , Chizuko Fukuhama
发明人： Kyoichi Kagawa , Chizuko Fukuhama
IPC分类号： A61K38/06
CPC分类号： A61K38/07 , A61K38/012
摘要： The present invention provides a composition (composition for suppressing re-elevation of cholesterol) that has the effects of suppressing re-elevation of cholesterol in patients with high cholesterol or pre-high cholesterol, and that can therefore be used to suppress re-elevation of cholesterol in those patients. The present invention also provides a composition which, due to the effects described above, can be used to prevent or treat conditions or diseases caused by high cholesterol due to cholesterol re-elevation, specifically hypercholesterolemia, arteriosclerosis and diseases and conditions stemming therefrom. The composition of this invention uses as an active component an edible protein hydrolysate, preferably a globin proteolysate or a peptide consisting of Val-Val-Tyr-Pro.
摘要翻译： 本发明提供了具有抑制高胆固醇或高胆固醇的患者胆固醇升高的作用的抑制胆固醇再升高的组合物（组合物），因此可以用于抑制胆固醇的再升高 那些患者胆固醇。 本发明还提供了一种由于上述效果可以用于预防或治疗由胆固醇升高引起的高胆固醇，特别是高胆固醇血症，动脉硬化以及由此产生的疾病和病症的组合物。 本发明的组合物使用可食性蛋白质水解物，优选珠蛋白蛋白水解物或由Val-Val-Tyr-Pro组成的肽作为活性成分。
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公开(公告)号：US20110166073A1
公开(公告)日：2011-07-07
申请号：US12671953
申请日：2008-08-07
IPC分类号： A61K38/06 , C07K5/097 , C07K5/087 , C07K5/103 , C07K5/117 , C07K7/06 , A61K38/07 , A61K38/08 , A61P9/12
摘要： The present invention provides an anti-hypertensive agent. The anti-hypertensive agent of the present invention contains, as an active ingredient, at least one peptide selected from the group consisting of peptides originally derived from globin proteolysate, each of which consists of one of the following amino acid sequences (1) to (6), or a globin proteolysate containing at least one of the peptides: (1) Val-Val-Tyr-Pro (SEQ ID: NO. 1); (2) Trp-Gly-Lys-Val-Asn (SEQ ID: NO. 2); (3) Trp-Gly-Lys-Val (SEQ ID: NO. 3); (4) Trp-Gly-Lys (SEQ ID: NO. 4); (5) Ala-Ala-Trp-Gly-Lys (SEQ ID: NO. 5); and (6) Phe-Glu-Ser (SEQ ID: NO. 6).
摘要翻译： 本发明提供抗高血压药。 作为活性成分，本发明的抗高血压剂含有选自由蛋白水解蛋白多糖最初来源的肽组成的组中的至少一种，其中的肽由以下氨基酸序列（1）〜（ 6）或含有至少一种肽的球蛋白蛋白水解物：（1）Val-Val-Tyr-Pro（SEQ ID NO：1）; （2）Trp-Gly-Lys-Val-Asn（SEQ ID NO：2）; （3）Trp-Gly-Lys-Val（SEQ ID NO：3）; （4）Trp-Gly-Lys（SEQ ID NO：4）; （5）Ala-Ala-Trp-Gly-Lys（SEQ ID NO：5）; 和（6）Phe-Glu-Ser（SEQ ID NO：6）。
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公开(公告)号：US20090155376A1
公开(公告)日：2009-06-18
申请号：US11719287
申请日：2005-11-15
CPC分类号： A61K38/017 , A23L33/18 , A23V2002/00 , A61K38/07 , C07K1/12 , C07K5/101 , C07K14/47 , A23V2200/328 , A23V2250/542
摘要： The present invention provides compositions (blood sugar increase inhibitors) that have an action of lowering the blood sugar level of a subject in a hyperglycemic condition and are for use in lowering the blood sugar level of such a subject. Moreover, the present invention provides compositions for use in preventing or treating diseases resulting from hyperglycemia, in particular, diabetes and diabetic complications, due to the aforementioned action (a preventive or ameliorative composition for diseases resulting from hyperglycemia, an antidiabetic agent).
摘要翻译： 本发明提供了具有降低受试者在高血糖状态下的血糖水平的作用的组合物（血糖增加抑制剂），并且用于降低该受试者的血糖水平。 此外，由于上述作用（用于由高血糖引起的疾病的预防性或改善性组合物，抗糖尿病药），本发明提供了用于预防或治疗由高血糖引起的疾病，特别是糖尿病和糖尿病并发症的组合物。
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公开(公告)号：US08394769B2
公开(公告)日：2013-03-12
申请号：US12671953
申请日：2008-08-07
摘要： The present invention provides an anti-hypertensive agent. The anti-hypertensive agent of the present invention contains, as an active ingredient, at least one peptide selected from the group consisting of peptides originally derived from globin proteolysate, each of which consists of one of the following amino acid sequences (1) to (6), or a globin proteolysate containing at least one of the peptides: (1) Val-Val-Tyr-Pro (SEQ ID: NO. 1); (2) Trp-Gly-Lys-Val-Asn (SEQ ID: NO. 2); (3) Trp-Gly-Lys-Val (SEQ ID: NO. 3); (4) Trp-Gly-Lys (SEQ ID: NO. 4); (5) Ala-Ala-Trp-Gly-Lys (SEQ ID: NO. 5); and (6) Phe-Glu-Ser (SEQ ID: NO. 6).
摘要翻译： 本发明提供抗高血压药。 作为活性成分，本发明的抗高血压剂含有选自由蛋白水解蛋白多糖最初来源的肽组成的组中的至少一种，其中的肽由以下氨基酸序列（1）〜（ 6）或含有至少一种肽的球蛋白蛋白水解物：（1）Val-Val-Tyr-Pro（SEQ ID NO：1）; （2）Trp-Gly-Lys-Val-Asn（SEQ ID NO：2）; （3）Trp-Gly-Lys-Val（SEQ ID NO：3）; （4）Trp-Gly-Lys（SEQ ID NO：4）; （5）Ala-Ala-Trp-Gly-Lys（SEQ ID NO：5）; 和（6）Phe-Glu-Ser（SEQ ID NO：6）。
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