公开(公告)号：US10400759B2

公开(公告)日：2019-09-03

申请号：US14258763

申请日：2014-04-22

申请人： Jason Shih ,  Jiangang Du ,  Blake W. Axelrod ,  Changlin Pang

发明人： Jason Shih ,  Jiangang Du ,  Blake W. Axelrod ,  Changlin Pang

IPC分类号： F04B49/02 ,  G01F1/684 ,  G01F1/692

摘要： Modular microfluidic channel structures for conducting liquid from a reservoir include a sensor for monitoring a parameter (such as flow rate or pressure) relating to liquid flowing therethrough. The microfluidic channel generally comprises a thermally insulating substrate made of one or more materials such as, e.g., glass, fused silica, parylene, and/or silicone.

公开(公告)号：US10390856B2

公开(公告)日：2019-08-27

申请号：US13351836

申请日：2012-01-17

申请人： Michelle Journey ,  Sean Caffey ,  Mark Humayun ,  John Huculak

发明人： Michelle Journey ,  Sean Caffey ,  Mark Humayun ,  John Huculak

IPC分类号： A61B17/28 ,  A61B17/30 ,  A61B17/00 ,  A61B17/29 ,  A61F9/00 ,  A61F13/51

摘要： Surgical introducers aid surgeons in the implantation of medical devices. The introducer provides support and an even distribution of force for ease of insertion and prevention of damage to the medical device while protecting the tissue into which the device is implanted. A representative embodiment includes or consists of a locking device, a pair of forceps, a specially configured and/or angled head with a seat for the device to be implanted, and a gripping area.

公开(公告)号：US10286146B2

公开(公告)日：2019-05-14

申请号：US13632722

申请日：2012-10-01

申请人： MiniPumps, LLC

发明人： Jason Shih ,  Sean Caffey

IPC分类号： A61M5/162 ,  A61M5/142 ,  A61M39/02

摘要： A system for refilling the drug reservoir of an implanted drug pump device may facilitate wireless data exchange between the refill system and the implanted device, e.g., to verify proper drug selection prior to commencement of the refill process. Via the wireless link, the drug pump device and refill system can exchange data such as, for example, refill information (including, e.g., a type of drug), a drug pump device history, a drug dosage log, and/or a drug-delivery protocol. Further, the refill system can facilitate reprogramming the implanted device wirelessly.

公开(公告)号：US08939930B2

公开(公告)日：2015-01-27

申请号：US13680828

申请日：2012-11-19

申请人： MiniPumps, LLC.

发明人： Po-Ying Li ,  Jonathan Lee ,  Alice Lai ,  Yu-Chong Tai ,  Sean Caffey ,  Stuart Long

IPC分类号： A61M5/172 ,  A61M5/168 ,  A61M5/145 ,  A61M5/155

CPC分类号： A61M5/172 ,  A61M5/14248 ,  A61M5/14566 ,  A61M5/155 ,  A61M5/16854 ,  A61M2005/14252 ,  A61M2039/1072 ,  A61M2205/14

摘要： The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.

摘要翻译： 通过在高流量阻力和泵压力下的泵操作，压力释放机构和用于泵控制的基于传感器的反馈的组合可以改善药物泵装置的药物递送的准确性。

公开(公告)号：US08915904B2

公开(公告)日：2014-12-23

申请号：US13491741

申请日：2012-06-08

申请人： Jeffrey Brennan ,  Sean Caffey ,  Michelle Journey ,  Fukang Jiang

发明人： Jeffrey Brennan ,  Sean Caffey ,  Michelle Journey ,  Fukang Jiang

IPC分类号： A61K9/22 ,  H01Q1/36 ,  A61M5/142

CPC分类号： A61M5/142 ,  Y10T29/49016

摘要： A spiral-coil antenna conforming to a non-planar contour is deployed, in various embodiments, in an implantable device for controllably ejecting fluid into an anatomic region. The antenna facilitates wireless communications with the implantable device and external charging thereof. In one implementation, the device has a non-planar contour and the spiral coil defines a non-planar surface conforming to the non-planar contour.

摘要翻译： 在各种实施例中，在可植入装置中部署符合非平面轮廓的螺旋线圈天线，用于将流体可控地喷射到解剖区域中。 天线便于与可植入装置的无线通信及其外部充电。 在一个实施方案中，该装置具有非平面轮廓，并且螺旋线圈限定符合非平面轮廓的非平面表面。

公开(公告)号：US20130184640A1

公开(公告)日：2013-07-18

申请号：US13680990

申请日：2012-11-19

申请人： MiniPumps, LLC

发明人： Po-Ying Li

IPC分类号： A61M5/172

CPC分类号： A61M5/172 ,  A61M5/14248 ,  A61M5/14276 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/1684 ,  A61M5/16886 ,  A61M2005/14204 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2210/0612

摘要： The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.

公开(公告)号：US20130102962A1

公开(公告)日：2013-04-25

申请号：US13709301

申请日：2012-12-10

申请人： MiniPumps, LLC

发明人： Jason Shih ,  Changlin Pang ,  Fukang Jiang ,  Sean Caffey ,  Mark Humayun ,  Yu-Chong Tai ,  Raymond Peck

IPC分类号： A61M5/142 ,  A61M5/36

CPC分类号： A61M5/14212 ,  A61F9/0017 ,  A61M5/14276 ,  A61M5/148 ,  A61M5/16881 ,  A61M5/36 ,  A61M39/0208 ,  A61M2005/1403 ,  A61M2039/0072 ,  A61M2039/0081 ,  A61M2039/0235 ,  A61M2209/045

摘要： In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

公开(公告)号：US08285328B2

公开(公告)日：2012-10-09

申请号：US13091041

申请日：2011-04-20

申请人： Sean Caffey ,  Po-Ying Li ,  Jeffrey Brennan

发明人： Sean Caffey ,  Po-Ying Li ,  Jeffrey Brennan

IPC分类号： H04B1/38

CPC分类号： A61M5/14526 ,  A61M5/14248 ,  A61M5/14276 ,  A61M5/14593 ,  A61M5/1684 ,  A61M5/16886 ,  A61M2005/14204 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2210/0612

摘要： Drug pump devices may be remotely controlled and/or reprogrammed by a smartphone or other wireless handheld device.

摘要翻译： 药物泵装置可以由智能手机或其他无线手持装置远程控制和/或重新编程。

公开(公告)号：US10369079B2

公开(公告)日：2019-08-06

申请号：US14579231

申请日：2014-12-22

申请人： Andres Rodriguez ,  Pedrum Minaie ,  Tun Min Soe ,  Jason Shih ,  Andrew Dunn ,  Andrew Urazaki ,  Bin Wang ,  Fukang Jiang

发明人： Andres Rodriguez ,  Pedrum Minaie ,  Tun Min Soe ,  Jason Shih ,  Andrew Dunn ,  Andrew Urazaki ,  Bin Wang ,  Fukang Jiang

IPC分类号： A61J1/20 ,  A61J1/22 ,  B65B3/00 ,  A61M5/142

摘要： Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

公开(公告)号：US09845895B2

公开(公告)日：2017-12-19

申请号：US14153662

申请日：2014-01-13

申请人： Yu-Chong Tai ,  Po-Ying Li ,  Fukang Jiang ,  Changlin Pang ,  Natasha Yvette Bouey ,  Man Ting Chou ,  Atoosa Lotfi

发明人： Yu-Chong Tai ,  Po-Ying Li ,  Fukang Jiang ,  Changlin Pang ,  Natasha Yvette Bouey ,  Man Ting Chou ,  Atoosa Lotfi

IPC分类号： F16K15/14 ,  F16K99/00 ,  B29C70/76 ,  B29L31/00 ,  B29C39/10 ,  B29C41/20 ,  B29C45/14

CPC分类号： F16K15/147 ,  B29C39/10 ,  B29C41/20 ,  B29C45/14598 ,  B29C70/766 ,  B29L2031/753 ,  B29L2031/756 ,  F16K15/145 ,  F16K99/0057 ,  F16K2099/0078 ,  Y10T137/0497 ,  Y10T137/7895

摘要： Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded to the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.