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    Sinus-engaging valve fixation member
    2.
    发明授权
    Sinus-engaging valve fixation member 有权

    公开(公告)号：US11304801B2

    公开(公告)日：2022-04-19

    申请号：US17222926

    申请日：2021-04-05

    申请人： MEDTRONIC VENTOR TECHNOLOGIES LTD.

    发明人： Yossi Tuval ,  Raphael Benary ,  Ido Kilemnik

    IPC分类号： A61F2/24 ,  A61F2/91 ,  A61F2/95

    摘要： A prosthesis is provided for implantation at a native semilunar valve of a native valve complex, the native valve complex having three semilunar sinuses and three native commissures. The prosthesis includes a valve prosthesis support, which comprises a support structure comprising exactly three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as define three peak complexes at the three respective junctures, and three trough complexes, each of which is between two of the peak complexes. Upon implantation of the prosthesis, each of the engagement arms is at least partially disposed within a respective one of the semilunar sinuses, such that each of the peak complexes is disposed distal to and in rotational alignment with a respective one of the native commissures, and each of the trough complexes is disposed at least partially within the respective one of the semilunar sinuses.

    Sinus-engaging valve fixation member
    3.
    发明授权
    Sinus-engaging valve fixation member 有权

    公开(公告)号：US11304800B2

    公开(公告)日：2022-04-19

    申请号：US16724358

    申请日：2019-12-22

    申请人： MEDTRONIC VENTOR TECHNOLOGIES LTD.

    发明人： Yossi Tuval ,  Raphael Benary ,  Ido Kilemnik

    IPC分类号： A61F2/24 ,  A61F2/91 ,  A61F2/95

    摘要： A prosthesis is provided for implantation at a native semilunar valve of a native valve complex, the native valve complex having three semilunar sinuses and three native commissures. The prosthesis includes a valve prosthesis support, which comprises a support structure comprising exactly three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as define three peak complexes at the three respective junctures, and three trough complexes, each of which is between two of the peak complexes. Upon implantation of the prosthesis, each of the engagement arms is at least partially disposed within a respective one of the semilunar sinuses, such that each of the peak complexes is disposed distal to and in rotational alignment with a respective one of the native commissures, and each of the trough complexes is disposed at least partially within the respective one of the semilunar sinuses.

    Catheter assembly with valve crimping accessories
    5.
    发明授权
    Catheter assembly with valve crimping accessories 有权
    导管组件带阀门压接配件

    公开(公告)号：US09414914B2

    公开(公告)日：2016-08-16

    申请号：US12911458

    申请日：2010-10-25

    申请人： Niall Duffy ,  Paul Mearns ,  John Gallagher ,  Noam Miller

    发明人： Niall Duffy ,  Paul Mearns ,  John Gallagher ,  Noam Miller

    IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/95

    CPC分类号： A61F2/2427 ,  A61F2/95 ,  A61F2002/9522 ,  Y10T29/53996

    摘要： Catheter assemblies including a handle assembly located on the proximal end of the catheter assembly and a distal tip assembly located on the distal end of the catheter assembly. A crimping funnel is slidably positioned along the catheter. The crimping funnel includes a distal end having a first diameter and a proximal end having a second diameter smaller than the first diameter. An axial split is formed in the proximal end. A first collar is provided encompassing a portion of the proximal end. The first collar is configured to hold the axial split in the proximal end together when the first collar is at a first axial location along the proximal end, and to allow the axial split in the proximal end to open when the first collar is at a second axial location along the proximal end, such that the crimping funnel can be removed from the catheter assembly. Various methods of retaining a prosthetic valve on the catheter assembly during the crimping process are described.

    摘要翻译： 导管组件包括位于导管组件的近端上的把手组件和位于导管组件的远端上的远侧末端组件。 压接漏斗沿着导管可滑动地定位。 卷曲漏斗包括具有第一直径的远端和具有小于第一直径的第二直径的近端。 在近端形成轴向分裂。 提供包围近端的一部分的第一套环。 当第一颈圈沿着近端位于第一轴向位置时，第一颈圈被构造成将近端中的轴向分裂保持在一起，并且当第一颈圈在第二颈圈处于第二颈圈时允许近端中的轴向分裂打开 沿着近端的轴向位置，使得可以从导管组件移除压接漏斗。 描述了在压接过程期间将修复瓣膜保持在导管组件上的各种方法。

    Valve prosthetic fixation techniques using sandwiching
    6.
    发明授权
    Valve prosthetic fixation techniques using sandwiching 有权
    使用夹心的瓣膜假体固定技术

    公开(公告)号：US08771346B2

    公开(公告)日：2014-07-08

    申请号：US13190397

    申请日：2011-07-25

    申请人： Yosi Tuval ,  Ido Kilemnik ,  Raphael Benary

    发明人： Yosi Tuval ,  Ido Kilemnik ,  Raphael Benary

    IPC分类号： A61F2/24 ,  A61F2/95

    CPC分类号： A61F2/2469 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2002/9522 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0071 ,  A61F2230/008 ,  A61F2250/0039

    摘要： A prosthesis is provided for implantation at a native semilunar valve of a native valve complex. The prosthesis includes a distal fixation member, configured to be positioned in a downstream artery, and shaped so as to define exactly three proximal engagement arms that are configured to be positioned at least partially within respective ones of semilunar sinuses, and, in combination, to apply, to tissue that defines the semilunar sinuses, a first axial force directed toward a ventricle. The prosthesis further includes a proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native semilunar valve, and to apply, to the ventricular side of the native valve complex, a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex.

    摘要翻译： 假体被提供用于植入天然瓣膜复合体的天然半月瓣。 假体包括远端固定构件，其被配置为定位在下游动脉中，并且成形为准确地限定三个近侧接合臂，所述三个近侧接合臂被构造成至少部分地定位在半月窦的相应的半月形窦内，并且组合到 适用于限定半月窦的组织，指向心室的第一轴向力。 所述假体还包括联接到所述远端固定构件的近端固定构件，所述近端固定构件构造成至少部分地定位在所述自然半月瓣的心室侧，并且将所述近端固定构件施加到所述天然瓣膜复合体的心室侧， 指向下游动脉的第二轴向力，使得施加第一和第二力将假体耦合到自然瓣膜复合体。

    Devices and Methods for Loading a Prosthesis Onto a Delivery System
    7.
    发明申请
    Devices and Methods for Loading a Prosthesis Onto a Delivery System 审中-公开
    将假体装载到运送系统的装置和方法

    公开(公告)号：US20140067053A1

    公开(公告)日：2014-03-06

    申请号：US14058643

    申请日：2013-10-21

    申请人： Medtronic Ventor Technologies Ltd.

    发明人： Paul Mearns ,  John Gallagher ,  Kevin O'Sullivan ,  Mark Casley ,  Pat Duane

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2002/9522 ,  A61F2220/0075 ,  Y10T29/53843

    摘要： A method for loading a prosthesis onto a delivery system includes passing a distal end of a delivery system through a first open end and a second open end of a reducing member. The method includes seating the prosthesis in a piston member of a cap by contacting a first end of the prosthesis with a first surface of the piston member and by contacting a portion of a side of the prosthesis with at least one side wall extending from the periphery of the first surface. Additionally, the method includes inserting the distal end of the delivery system into a center of the prosthesis and an opening defined by the piston member. And the method includes advancing the cap towards a reducing member such that a portion of the prosthesis seated in the piston member advances along an inner surface of the conical wall of the reducing member.

    摘要翻译： 用于将假体装载到输送系统上的方法包括使输送系统的远端通过还原构件的第一开口端和第二开口端。 该方法包括通过使假体的第一端与活塞构件的第一表面接触并使假体的一侧的一部分与从周边延伸的至少一个侧壁接触来将假体置于帽的活塞构件中 的第一个表面。 另外，该方法包括将输送系统的远端插入假体的中心和由活塞构件限定的开口。 并且该方法包括将帽朝向减小构件推进，使得坐在活塞构件中的假体的一部分沿着还原构件的锥形壁的内表面前进。

    Devices and methods for loading a prosthesis onto a delivery system
    8.
    发明授权
    Devices and methods for loading a prosthesis onto a delivery system 有权
    用于将假体装载到输送系统上的装置和方法

    公开(公告)号：US08562663B2

    公开(公告)日：2013-10-22

    申请号：US12912479

    申请日：2010-10-26

    申请人： Paul Mearns ,  John Gallagher ,  Kevin O'Sullivan ,  Mark Casley ,  Pat Duane

    发明人： Paul Mearns ,  John Gallagher ,  Kevin O'Sullivan ,  Mark Casley ,  Pat Duane

    IPC分类号： A61F2/24 ,  A61F2/06 ,  A61F5/00

    CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2002/9522 ,  A61F2220/0075 ,  Y10T29/53843

    摘要： In an embodiment, a device for loading a prosthesis onto a delivery system comprises a cap and a reducing member. The cap has a piston member that seats a prosthesis. The piston member has at least one side wall configured to contact a portion of the side of the prosthesis seated therein. The reducing member has a conical wall, a first open end, and a second open end. The first open end is configured to receive the piston member. The reducing member reduces an external dimension of at least a portion of the prosthesis seated in the piston member as the prosthesis is moved along an inner surface of the conical wall.

    摘要翻译： 在一个实施例中，用于将假体装载到输送系统上的装置包括盖和还原构件。 盖具有一个活塞构件，用于支撑假体。 所述活塞构件具有至少一个侧壁，所述至少一个侧壁构造成接触其中安置的所述假体的一侧的一部分。 还原构件具有锥形壁，第一开口端和第二开口端。 第一开口端构造成接收活塞构件。 当假体沿着锥形壁的内表面移动时，还原构件减小了坐在活塞构件中的假体的至少一部分的外部尺寸。

    Axial-force fixation member for valve
    9.
    发明授权
    Axial-force fixation member for valve 有权
    阀轴向力固定件

    公开(公告)号：US08348995B2

    公开(公告)日：2013-01-08

    申请号：US11726875

    申请日：2007-03-23

    申请人： Yosi Tuval ,  Ido Kilemnik ,  Raphael Benary

    发明人： Yosi Tuval ,  Ido Kilemnik ,  Raphael Benary

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2469 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2002/9522 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0071 ,  A61F2230/008 ,  A61F2250/0039

    摘要： A prosthesis is provided for implantation at a native semilunar valve of a native valve complex. The prosthesis includes a distal fixation member, configured to be positioned in a downstream artery, and to apply a first axial force directed toward a ventricle. The prosthesis further includes a proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side. A ratio of the first axial force to a radial force applied outwardly by the prosthesis against the native semilunar valve is greater than 1.5:1. Other embodiments are also described.

    摘要翻译： 假体被提供用于植入天然瓣膜复合体的天然半月瓣。 假体包括远端固定构件，其构造成定位在下游动脉中，并施加朝向心室的第一轴向力。 所述假体还包括联接到所述远侧固定构件的近端固定构件，所述近端固定构件构造成至少部分地定位在所述自然瓣膜复合体的心室侧，并且施加朝向所述下游动脉的第二轴向力， 第一和第二力的应用通过从下游侧和心室侧轴向夹住天然瓣膜复合体将假体联接到天然瓣膜复合体。 第一轴向力与假体相对于自然半月瓣向外施加的径向力的比值大于1.5:1。 还描述了其它实施例。

    Mitral Valve Repair
    10.
    发明申请
    Mitral Valve Repair 有权
    二尖瓣修复

    公开(公告)号：US20120226349A1

    公开(公告)日：2012-09-06

    申请号：US13038097

    申请日：2011-03-01

    申请人： Yosi Tuval ,  Ilia Hariton

    发明人： Yosi Tuval ,  Ilia Hariton

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2409 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00783 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0441 ,  A61B2017/0443 ,  A61B2017/06095 ,  A61B2017/0649 ,  A61B2017/22038 ,  A61F2/2445 ,  A61F2/2457

    摘要： Apparatus and methods are provided for use with a mitral valve of a heart of a subject. The apparatus includes a P1-anchor, a P2-anchor, and a P3-anchor, that are anchored to tissue in a vicinity of, respectively, P1, P2 and P3 segments of a posterior leaflet of the mitral valve, a tether being fixedly coupled to the P2-anchor, and slidably coupled to the P1 and P3 anchors. A cardiac-site anchor anchors the tether to an anchoring location that is at a cardiac site that is anterior and inferior to the posterior leaflet. Other embodiments are also described.

    摘要翻译： 提供了与受试者心脏的二尖瓣一起使用的装置和方法。 该装置包括分别固定在二尖瓣后叶的P1，P2和P3段附近的组织的P1锚，P2锚和P3锚，系固固定 耦合到P2锚，并且可滑动地联接到P1和P3锚。 心脏锚定点将系绳锚固到位于前叶和下叶的心脏部位的锚定位置。 还描述了其它实施例。