-
公开(公告)号：US20220089575A1
公开(公告)日：2022-03-24
申请号：US17538394
申请日：2021-11-30
申请人： Metacrine, Inc.
IPC分类号： C07D403/12 , C07D417/12 , C07D275/02 , C07D413/12 , C07D417/04 , C07D231/12 , C07D401/12 , C07D277/28 , A61P1/16 , C07D413/14 , C07D417/14 , C07D263/32 , C07D401/14
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US10927082B2
公开(公告)日：2021-02-23
申请号：US16886642
申请日：2020-05-28
申请人： Metacrine, Inc.
IPC分类号： C07D231/12 , A61P1/16 , A61P1/00 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/48 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US20220056019A1
公开(公告)日：2022-02-24
申请号：US17276785
申请日：2019-09-17
申请人： Metacrine, Inc.
IPC分类号： C07D413/14 , C07D401/14 , C07D417/04 , C07D403/12 , C07D401/12 , C07D231/12 , C07D405/14 , C07D413/04 , C07D417/14 , C07D403/14 , C07D409/14
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US20210395253A1
公开(公告)日：2021-12-23
申请号：US17349757
申请日：2021-06-16
申请人： Metacrine, Inc.
IPC分类号： C07D471/14 , C07D487/04 , C07D417/14 , C07D413/14
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US20230120914A1
公开(公告)日：2023-04-20
申请号：US17906585
申请日：2021-03-17
申请人： Metacrine, Inc.
IPC分类号： A61K9/16 , A61K31/4439 , A61K9/20
摘要： Described herein are pharmaceutical formulations of a farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, and methods of using such pharmaceutical formulations in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US20220002309A1
公开(公告)日：2022-01-06
申请号：US17287781
申请日：2019-10-23
申请人： Metacrine, Inc.
IPC分类号： C07D491/107 , C07C237/24 , C07D309/14 , C07D295/185 , C07D257/04 , C07D241/18 , C07D273/01 , C07D498/08 , C07D307/22 , C07D307/93 , C07D233/60 , C07D205/04 , C07D231/12 , C07D241/04 , C07D239/42 , C07D239/34 , C07C311/14 , A61P1/16
摘要： Described herein are compounds that are semicarbazide-sensitive amine oxidase (SSAO) inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating or preventing a liver disease or condition.
-
公开(公告)号：US20210347736A1
公开(公告)日：2021-11-11
申请号：US17276763
申请日：2019-09-17
申请人： Metacrine, Inc.
IPC分类号： C07D231/12 , A61K9/16
摘要： Described herein is the farnesoid X receptor agonist, trans-N-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-4-hydroxy-N-((trans-4-(4-methoxy-3-methyl phenyl)cyclohexyl)methyl)cyclohexane-carboxamide, including crystalline forms and pharmaceutically acceptable salts, solvates, and formulations thereof.
-
公开(公告)号：US20220323414A1
公开(公告)日：2022-10-13
申请号：US17836905
申请日：2022-06-09
申请人： Metacrine, Inc.
发明人： Kenneth SONG , Hubert CHEN , Brandee WAGNER
IPC分类号： A61K31/415 , A61P1/16 , A61K9/00 , A61K45/06
摘要： Described herein are combination therapies with farnesoid X receptor (FXR) agonists, and methods of using such pharmaceutical compositions in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US20220081390A1
公开(公告)日：2022-03-17
申请号：US17532618
申请日：2021-11-22
申请人： Metacrine, Inc.
IPC分类号： C07C233/80 , C07D333/32 , C07D239/34 , C07D241/18 , C07D263/32 , C07D205/04 , C07D207/27 , C07D275/03 , C07D277/34 , C07D213/65 , A61K45/06 , C07D207/12 , C07D213/75 , C07D207/08 , C07D213/68 , C07D211/42 , C07D211/46 , C07D213/40 , C07D213/64 , C07D213/80 , C07C271/20 , C07C233/63 , C07C237/22 , C07C237/42 , C07C233/59 , C07C233/62 , A61K31/167 , A61K31/216 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/4418 , A61K31/445 , A61K31/4965 , A61K31/505 , C07D207/24 , C07D211/94
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
公开(公告)号：US20210300875A1
公开(公告)日：2021-09-30
申请号：US17152548
申请日：2021-01-19
申请人： Metacrine, Inc.
IPC分类号： C07D231/12 , A61P1/16 , A61P1/00 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/48 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.013 秒)
