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58 条记录 (耗时 0.064 秒)

    Total synthesis of salinosporamide A and analogs thereof
    1.
    发明授权
    Total synthesis of salinosporamide A and analogs thereof 失效
    salinosporamide A及其类似物的全合成

    公开(公告)号：US08314251B2

    公开(公告)日：2012-11-20

    申请号：US13184356

    申请日：2011-07-15

    申请人： Taotao Ling ,  Samuel Danishefsky

    发明人： Taotao Ling ,  Samuel Danishefsky

    IPC分类号： C07D263/00 ,  C07D498/04

    CPC分类号： C07D487/14 ,  C07D487/04

    摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

    摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
    5.
    发明授权
    Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof 有权
    脱氢苯基乙二烯和其类似物，以及脱氢苯基黑曲霉素及其类似物的合成

    公开(公告)号：US07935704B2

    公开(公告)日：2011-05-03

    申请号：US11051268

    申请日：2005-02-04

    申请人： Michael A. Palladino ,  George Kenneth Lloyd ,  Yoshio Hayashi ,  Benjamin Nicholson

    发明人： Michael A. Palladino ,  George Kenneth Lloyd ,  Yoshio Hayashi ,  Benjamin Nicholson

    IPC分类号： A61K31/497

    CPC分类号： A61K31/496

    摘要： Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

    摘要翻译： 公开了由以下结构（I）表示的化合物：制备这种化合物的方法，其中所述方法包括使二酰基二酮哌嗪与第一醛反应以产生中间体化合物; 并使所述中间体化合物与第二醛反应以产生一类具有通式结构的化合物，其中第一种醛和第二种醛选自恶唑烷羧醛，咪唑甲醛，苯甲醛，咪唑甲醛衍生物和苯甲醛衍生物， 从而形成上述化合物，其中R1，R1'，R1“，R2，R3，R4，R5和R6，X1和X2，Y，Z，Z1，Z2，Z3和Z4各自可以以一致的方式分别定义 附带说明。 还公开了治疗血管增生的组合物和方法。

    Total synthesis of Salinosporamide A and analogs thereof
    9.
    发明授权
    Total synthesis of Salinosporamide A and analogs thereof 有权
    Salinosporamide A及其类似物的全合成

    公开(公告)号：US08003802B2

    公开(公告)日：2011-08-23

    申请号：US12399382

    申请日：2009-03-06

    申请人： Taotao Ling ,  Samuel Danishefsky

    发明人： Taotao Ling ,  Samuel Danishefsky

    IPC分类号： C07D498/14 ,  C07D487/04

    CPC分类号： C07D487/14 ,  C07D487/04

    摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

    摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。