公开(公告)号：US08985103B2

公开(公告)日：2015-03-24

申请号：US13744923

申请日：2013-01-18

Applicant: Oriel Therapeutics, Inc.

Inventor： Gerald A. Thoe ,  James G. Skakoon ,  David A. Schuelke ,  Thomas W. Ruckdeschel ,  David Harris ,  Scott Alexander Lewis ,  Andrew Murray Gow ,  Jonathan David Tuckwell

IPC: A61M15/00

CPC classification number: A61M15/0041 ,  A61M15/0021 ,  A61M15/0026 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0075 ,  A61M2202/064

Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Abstract translation: 干粉吸入器包括具有剂量容器盘的剂量容器组件，其具有相对的上表面和下表面，在第一半径处具有第一排周向间隔开的剂量容器，在第二半径处具有第二排周向间隔开的剂量容器。 剂量容器在其中具有干粉，并通过第一柔性密封剂在上表面的孔上密封，并且在下表面上的孔上密封第二柔性密封剂。 穿刺机构包括两个在剂量容器盘中的两排剂量容器之间连续交替的往复式穿孔器。 可旋转的斜盘包括交错的同心关系的第一组和第二组周向间隔开的斜面元件，其被构造成在缩回位置和延伸位置之间移动第一和第二穿孔构件。

公开(公告)号：USD685461S1

公开(公告)日：2013-07-02

申请号：US29385525

申请日：2011-02-15

Applicant: Rachel Striebig ,  Matthew Allen ,  Thomas W. Ruckdeschel ,  Charles Buckner

Designer： Rachel Striebig ,  Matthew Allen ,  Thomas W. Ruckdeschel ,  Charles Buckner

公开(公告)号：US08381721B2

公开(公告)日：2013-02-26

申请号：US12566724

申请日：2009-09-25

Applicant: Gerald A. Thoe ,  James G. Skakoon ,  David A. Schuelke ,  Thomas W. Ruckdeschel ,  David Harris ,  Scott Alexander Lewis ,  Andrew Murray Gow ,  Jonathan David Tuckwell

Inventor： Gerald A. Thoe ,  James G. Skakoon ,  David A. Schuelke ,  Thomas W. Ruckdeschel ,  David Harris ,  Scott Alexander Lewis ,  Andrew Murray Gow ,  Jonathan David Tuckwell

IPC: A61M15/00 ,  A61M16/00

CPC classification number: A61M15/0041 ,  A61M15/0021 ,  A61M15/0026 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0075 ,  A61M2202/064

Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Abstract translation: 干粉吸入器包括具有剂量容器盘的剂量容器组件，其具有相对的上表面和下表面，在第一半径处具有第一排周向间隔开的剂量容器，在第二半径处具有第二排周向间隔开的剂量容器。 剂量容器在其中具有干粉，并通过第一柔性密封剂在上表面的孔上密封，并且在下表面上的孔上密封第二柔性密封剂。 穿刺机构包括两个在剂量容器盘中的两排剂量容器之间连续交替的往复式穿孔器。 可旋转的斜盘包括交错的同心关系的第一组和第二组周向间隔开的斜面元件，其被构造成在缩回位置和延伸位置之间移动第一和第二穿孔构件。

公开(公告)号：USD635246S1

公开(公告)日：2011-03-29

申请号：US29358375

申请日：2010-03-26

Applicant: Rachel Striebig ,  Matthew Allen ,  Thomas W. Ruckdeschel ,  Charles Buckner

Designer： Rachel Striebig ,  Matthew Allen ,  Thomas W. Ruckdeschel ,  Charles Buckner

公开(公告)号：US07520278B2

公开(公告)日：2009-04-21

申请号：US11043363

申请日：2005-01-26

Applicant: Timothy M. Crowder ,  Anthony J. Hickey ,  Jeffrey A. Warden

Inventor： Timothy M. Crowder ,  Anthony J. Hickey ,  Jeffrey A. Warden

IPC: A61M16/00

CPC classification number: B65D88/66 ,  A61M15/0003 ,  A61M15/0005 ,  A61M15/001 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0065 ,  A61M15/0075 ,  A61M2202/064 ,  A61M2205/18 ,  A61M2205/35 ,  A61M2205/52 ,  A61M2205/8206 ,  B65B37/04 ,  B65G53/66

Abstract: The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

Abstract translation: 本发明包括用于分配和/或保持吸入剂配制干粉物质的干粉吸入器以及相关的制造和分配方法，其可采用包括多个叠加频率的调幅非线性信号，该频率对应于先验流特征频率 的干粉被分配。 本发明还包括具有弹性柔性枢转盖的口袋式吸入器。

公开(公告)号：US06985798B2

公开(公告)日：2006-01-10

申请号：US10606678

申请日：2003-06-26

Applicant: Timothy M. Crowder ,  Anthony J. Hickey

Inventor： Timothy M. Crowder ,  Anthony J. Hickey

IPC: G06F17/00

CPC classification number: A61M15/0045 ,  A61M15/0003 ,  A61M15/0005 ,  A61M15/001 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/0075 ,  A61M15/0083 ,  A61M2202/064 ,  A61M2205/18 ,  A61M2205/35 ,  A61M2205/52 ,  A61M2205/8206 ,  B65B37/04 ,  B65D88/66 ,  B65G53/66

Abstract: Methods for flowably dispensing dry powders from a hopper having a dispensing port and a dry powder flow path can include: (a) generating a first non-linear vibration input signal, the first non-linear input signal comprising a plurality of different selected frequencies that correspond to a first dry powder formulation; (b) applying the first non-linear vibration input signal to a dispensing hopper having at least one dispensing port while the first dry powder formulation is flowing therethrough; and (c) dispensing a first meted quantity of the first dry powder through the dispensing port to a receiving member. Related devices and computer program products for dispensing dry powders are also described.

Abstract translation: 从具有分配端口和干粉流路的料斗流动地分配干粉的方法可以包括：（a）产生第一非线性振动输入信号，第一非线性输入信号包括多个不同的选定频率， 对应于第一干粉配方; （b）当所述第一干粉制剂流过其中时，将第一非线性振动输入信号施加到具有至少一个分配端口的分配料斗; 和（c）将第一量的第一干粉通过分配口分配到接收构件。 还描述了用于分配干粉的相关设备和计算机程序产品。

公开(公告)号：US09795749B2

公开(公告)日：2017-10-24

申请号：US14620469

申请日：2015-02-12

Applicant: Oriel Therapeutics, Inc.

Inventor： Gerald A. Thoe ,  James G. Skakoon ,  David A. Schuelke ,  Thomas W. Ruckdeschel ,  David Harris ,  Scott Alexander Lewis ,  Andrew Murray Gow ,  Jonathan David Tuckwell

IPC: A61M15/00

CPC classification number: A61M15/0041 ,  A61M15/0021 ,  A61M15/0026 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0075 ,  A61M2202/064

Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

公开(公告)号：US08776840B2

公开(公告)日：2014-07-15

申请号：US13029854

申请日：2011-02-17

Applicant: James R. Meckstroth

Inventor： James R. Meckstroth

IPC: B65B1/22

CPC classification number: B65B37/04 ,  B65B1/08

Abstract: Tubular dry powder feed systems in communication with a hopper of dry powder are configured with an in-line actuator that applies a flow vibration signal axially. The flow vibration signal can be a harmonic or non-harmonic signal, such as a sinusoidal, saw tooth, square wave or other signal and may be frequency or amplitude modulated.

Abstract translation: 与干粉料斗连通的管状干粉进料系统配置有轴向致动器，其沿轴向施加流动振动信号。 流动振动信号可以是谐波或非谐波信号，例如正弦，锯齿，方波或其他信号，并且可以是频率或幅度调制的。

公开(公告)号：US08671938B2

公开(公告)日：2014-03-18

申请号：US13735532

申请日：2013-01-07

Applicant: Oriel Therapeutics, Inc.

Inventor： Rachel Striebig ,  Matthew Allen ,  Thomas W. Ruckdeschel ,  Charles A. Buckner, III ,  David Harris ,  Scott Alexander Lewis ,  Andrew Murray Gow ,  Jonathan David Tuckwell

IPC: A61M11/00

CPC classification number: A61M15/0048 ,  A61M15/0021 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/0045 ,  A61M15/0075 ,  A61M2202/064 ,  Y10T29/49826

Abstract: Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Abstract translation: 干粉吸入器包括径向延伸的离散的，通常为剂量特异性的气道通道，其顺序地形成吸入路径的一部分，以使用吸入器将干粉输送给使用者。

公开(公告)号：US08375941B2

公开(公告)日：2013-02-19

申请号：US13169486

申请日：2011-06-27

Applicant: Michael King ,  Jeffrey Alan Warden ,  John Kim ,  Benjamin Finney ,  Nicholas Oxley

Inventor： Michael King ,  Jeffrey Alan Warden ,  John Kim ,  Benjamin Finney ,  Nicholas Oxley

IPC: A61M15/00 ,  B65D83/04 ,  B67D7/06

CPC classification number: A61M15/0028 ,  A61M15/0003 ,  A61M15/001 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/0038 ,  A61M15/004 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/006 ,  A61M15/008 ,  A61M15/0085 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/18 ,  A61M2205/3379 ,  A61M2205/35 ,  A61M2205/505 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/6081 ,  A61M2205/8206

Abstract: Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Abstract translation: 干粉吸入器包括：（a）吸入器主体中的第一大致平面的螺旋行进路径，其中第一螺旋行进路径具有多个相邻的曲线通道，其形成具有直立侧壁的车道，包括内车道和外车道; 和（b）多个离散密封的微型组件，其具有设置在第一行进路径中的基本上刚性的物体，每个包含预先计量（典型地为剂量）的干粉末，该微型组件被构造成沿着第一行进路径朝向 吸入室合并成吸入口。 在操作中，吸入室中至少有一个微型小瓶被保持在其中以在吸入期间释放其中的干粉。