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    Detection and identification of bacterial strains
    2.
    发明授权
    Detection and identification of bacterial strains 有权

    公开(公告)号：US07087376B2

    公开(公告)日：2006-08-08

    申请号：US10060618

    申请日：2002-01-30

    申请人： Stefan Miller

    发明人： Stefan Miller

    IPC分类号： C12Q1/00 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/70 ,  G01N33/53

    CPC分类号： C12Q1/04 ,  C12Q2304/10 ,  G01N33/56911 ,  G01N33/56983 ,  G01N2333/924

    摘要： The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.

    Detection and identification of bacterial strains
    3.
    发明申请
    Detection and identification of bacterial strains 有权
    细菌菌株的检测和鉴定

    公开(公告)号：US20020127547A1

    公开(公告)日：2002-09-12

    申请号：US10060618

    申请日：2002-01-30

    申请人： PROFOS AG

    发明人： Stefan Miller

    IPC分类号： C12Q001/70 ,  G01N033/554 ,  G01N033/569 ,  G01N033/53 ,  G01N033/537 ,  G01N033/543

    CPC分类号： C12Q1/04 ,  C12Q2304/10 ,  G01N33/56911 ,  G01N33/56983 ,  G01N2333/924

    摘要： The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.

    摘要翻译： 本发明涉及一种检测细菌的方法，该方法包括以下步骤：将噬菌体和/或噬菌体蛋白偶联到载体上，将与噬菌体和/或噬菌体蛋白质偶联的载体与样品一起孵育，任选地除去 样品和样品中的细菌不结合噬菌体和/或噬菌体蛋白质，任选地添加渗透或破坏细菌膜的物质，以及检测与噬菌体和/或噬菌体蛋白质结合的样品中的细菌，其中结合的细菌是 没有进行培养步骤。

    Protein
    7.
    发明授权
    Protein 有权
    蛋白

    公开(公告)号：US07371375B2

    公开(公告)日：2008-05-13

    申请号：US10503556

    申请日：2003-01-22

    申请人： Markus Zimmer ,  Martin Loessner ,  Andrew John Morgan

    发明人： Markus Zimmer ,  Martin Loessner ,  Andrew John Morgan

    IPC分类号： A61K38/43 ,  A61K38/46 ,  A01N37/18

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2795/10022

    摘要： A nucleic acid comprising a nucleotide sequence encoding a lysin, which nucleotide sequence comprises the sequence shown in SEQ ID No. 1 or a variant, homologue or derivative thereof. A novel lysin obtainable from a bacteriophage capable of colonising Clostridium perfringens, and the use thereof as a medicament for the treatment of a disorder associated with pathogenic Clostridium bacteria, for example.

    摘要翻译： 包含编码赖氨酸的核苷酸序列的核酸，所述核苷酸序列包含SEQ ID No.1所示的序列或其变体，同系物或衍生物。 可从能够定殖产气荚膜梭菌的噬菌体获得的新型赖氨酸及其作为用于治疗与病原性梭菌属细菌相关的病症的药物的用途。