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公开(公告)号：US20230219986A1
公开(公告)日：2023-07-13
申请号：US17913525
申请日：2021-03-19
发明人： Wei DENG , Shansong ZHENG , Sebastien Andre CAMPOS , Yingying YANG , Zhenhua TIAN , Qingmei ZHENG , Guosheng WU , Zhiwei ZHAO , Leilei LI , Jianmin FU , Shuyong ZHAO
IPC分类号： C07F9/6558 , C07F9/6561 , C07D403/12 , C07D403/14 , C07D401/14 , C07D471/10 , C07D498/10 , A61P35/00
CPC分类号： C07F9/65583 , C07F9/6561 , C07F9/65586 , C07D403/12 , C07D403/14 , C07D401/14 , C07D471/10 , C07D498/10 , C07F9/65615 , A61P35/00 , C07B2200/05
摘要： The present invention provides a novel aminopyrimidine compound as a fourth-generation EGFR (T790M/C797S mutation) selective inhibitor, a pharmaceutical composition comprising the compound, an intermediate useful for preparing the compound, and a method for treating a cell proliferative disease, such as a cancer, by using the compound of the present invention.
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公开(公告)号：US20240216402A1
公开(公告)日：2024-07-04
申请号：US18557535
申请日：2022-07-04
发明人： Xiaoqing ZHENG , Lizhen CHENG , Weifeng GENG , Qingmin YANG
IPC分类号： A61K31/675 , A61K9/20 , A61K9/28
CPC分类号： A61K31/675 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K9/28
摘要： A pharmaceutical composition, and a preparation method therefor and an application thereof. The pharmaceutical composition comprises a spiro-aryl phosphorus oxide or a pharmaceutically acceptable salt thereof as an active ingredient and a pharmaceutically acceptable carrier. D90 of the spiro-aryl phosphorus oxide or the pharmaceutically acceptable salt thereof is in a range of 40.3 μm to 79.6 μm. The pharmaceutical composition has high content uniformity, a high dissolution rate, and high in-vivo bioavailability, and can be used for treating cancer.
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3.发明授权4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors 有权用作酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物公开(公告)号：US08916574B2
公开(公告)日：2014-12-23
申请号：US13498547
申请日：2010-09-20
申请人： Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
发明人： Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D405/04
摘要： The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.
摘要翻译： 本发明涉及作为酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物。 具体地，公开了式I化合物或其药学上可接受的盐或溶剂合物，其中式I中的每个取代基在说明书中定义。 还公开了式I化合物的制备方法，药物组合物及其药物用途。 式I化合物是有效的酪氨酸激酶抑制剂。
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公开(公告)号：US20240180823A1
公开(公告)日：2024-06-06
申请号：US18527129
申请日：2023-12-01
发明人： Min ZHANG , Qingmin YANG , Yongli TAN , Ping HE , Shuaishuai WANG , Guiming LIN , Xiaoqing CHENG
IPC分类号： A61K9/00 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26 , A61M11/00
CPC分类号： A61K9/0073 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/26 , A61M11/001
摘要： The present invention provides an inhalation spray of Semaglutide with good patient compliance and high bioavailability at the targeted site, which belongs to the technical field of pharmaceutical preparation. The inhalation spray of Semaglutide according to the invention comprising, by weight to volume, 0.01% to 20% of Semaglutide in the inhalation spray, wherein the proportion of fine particles with a particle size less than 5 μm formed after the inhalation spray is atomized by a spray device is not less than 10%. The inhalation spray of Semaglutide according to the invention has a simple formulation, low toxic and side effects, atomization administration of the medicinal liquid through an inhalation device, uniform distribution of spray droplets, a high lung deposition rate, low irritation and convenient administration, which is suitable for industrial production. The invention further provides a preparation method of the inhalation spray of Semaglutide.
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公开(公告)号：US10253030B2
公开(公告)日：2019-04-09
申请号：US15772942
申请日：2016-11-02
发明人： Haiying He , Kai Zhou , Xiaolin Li , Xiaofei Wang , Dakun Qin , Xingxing Wang , Feifei Yang , Zheng Wang , Zongbin Li
IPC分类号： C07D487/04 , A61P31/20 , C07C269/06
摘要： Disclosed in the present disclosure are a crystal form of a dihydropyrido ring compound, and preparation method and intermediate thereof.
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公开(公告)号：US09938301B2
公开(公告)日：2018-04-10
申请号：US15314599
申请日：2015-05-27
发明人： Haiying He , Kai Zhou , Hua Qin , Xiaolin Li , Yuedong Zhou , Xiaofei Wang , Xuemei Chi , Jian Li , Shuhui Chen
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , C07D487/10 , C07D513/04
CPC分类号： C07D513/04 , A61K31/519 , A61K31/527 , A61K31/5377 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/04
摘要： Disclosed is a dihydropyrimido fused ring derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240034743A9
公开(公告)日：2024-02-01
申请号：US17996265
申请日：2021-04-13
发明人： Shansong ZHENG , Wei DENG , Sebastien Andre CAMPOS , Yingying YANG , Zhenhua TIAN , Qingmei ZHENG , Guosheng WU , Zhiwei ZHAO , Leilei LI , Jianmin FU , Shuyong ZHAO
IPC分类号： C07F9/6561 , C07D519/00 , C07D487/04
CPC分类号： C07F9/6561 , C07D519/00 , C07D487/04
摘要： Provided are a class of compounds, represented by formula (I′″), as selective EGFR inhibitors, a pharmaceutical composition containing the compounds, useful intermediates for preparing the compounds, and a method for using the compounds of the present invention to treat cell proliferative diseases, such as cancers.
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8.发明授权Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof 失效吡咯基取代的二氢吲哚-2-酮衍生物，其制备方法和用途公开(公告)号：US08637681B2
公开(公告)日：2014-01-28
申请号：US13702956
申请日：2011-03-31
申请人： Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
发明人： Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D411/06 , A61K31/403 , A61K31/497 , A61K31/535
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14
摘要： Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
摘要翻译： 提供由式（I）表示的吡咯基取代的二氢吲哚-2-酮衍生物，所述衍生物的药学上可接受的盐或溶剂合物，或所述盐的溶剂化物，其是有效的酪氨酸激酶抑制剂。 还提供了上述化合物的制备方法，含有这些化合物的药物组合物，以及这些化合物在制备可用于治疗或辅助治疗由酪氨酸激酶药物或由酪氨酸激酶驱动的肿瘤细胞的增殖或迁移的药物中的用途 在哺乳动物（包括人）。
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公开(公告)号：US20240308990A1
公开(公告)日：2024-09-19
申请号：US18263799
申请日：2022-01-24
发明人： Chuanxin LENG , Huicheng WANG , Xi FANG , Chuanwen FAN , Dong LIN , Tao LIU , Zhaowei HUANG , Fang CHENG , Shuailong HUANG
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Crystal forms of Entrectinib and preparation method therefor, such as crystal form A and crystal form B of Entrectinib are provided. Compared with existing crystal forms of Entrectinib, the crystal form has better solubility, chemical and crystal form stability, is free of static electricity, has good fluidity, is easy for large-scale preparation, and can be better suitable for preparing pharmaceutical formulations and large-scale production.
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公开(公告)号：US20230192734A1
公开(公告)日：2023-06-22
申请号：US17996265
申请日：2021-04-13
发明人： Shansong ZHENG , Wei DENG , Sebastien Andre CAMPOS , Yingying YANG , Zhenhua TIAN , Qingmei ZHENG , Guosheng WU , Zhiwei ZHAO , Leilei LI , Jianmin FU , Shuyong ZHAO
IPC分类号： C07F9/6561 , C07D519/00 , C07D487/04
CPC分类号： C07F9/6561 , C07D519/00 , C07D487/04
摘要： Provided are a class of compounds, represented by formula (I′″), as selective EGFR inhibitors, a pharmaceutical composition containing the compounds, useful intermediates for preparing the compounds, and a method for using the compounds of the present invention to treat cell proliferative diseases, such as cancers.
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