Integral interstitial fluid sensor
    3.
    发明授权
    Integral interstitial fluid sensor 失效
    整体式间接流体传感器

    公开(公告)号:US5161532A

    公开(公告)日:1992-11-10

    申请号:US511329

    申请日:1990-04-19

    Applicant: Jose P. Joseph

    Inventor: Jose P. Joseph

    CPC classification number: A61B5/1486 A61B5/14514 A61B5/441 A61B2010/008

    Abstract: An integral interstitial fluid sensor for application to the skin of a person or an animal for the detection of chemical components of tissue fluid is disclosed. The fluid sensor comprises a substrate of a porous material for the passage of the interstitial fluid therethrough. At least two electrodes are provided. One of the electrodes has two sides, with one side mounted on the substrate. The electrode is also of a porous material and permits the passage of the interstitial fluid from one side through to the second side which is generally opposite the one side. A layer of chemical is on the second side. The layer of chemical comprises a chemical for reaction with one component of the fluid, mixed in a mediating agent. The electrodes generate an electrical signal upon the detection of the reaction of the one component of the fluid with the chemical. The electrical signal is received by a detector and a display is generated, indicating the amount of the one component detected. Finally, a pump for sucking the fluid from the skin into the sensor is disclosed.

    Microsensors for gaseous and vaporous species
    5.
    发明授权
    Microsensors for gaseous and vaporous species 失效
    气态和蒸气物种的微量传感器

    公开(公告)号:US5304293A

    公开(公告)日:1994-04-19

    申请号:US882459

    申请日:1992-05-11

    CPC classification number: G01N27/4045

    Abstract: A sensor for gaseous and vaporous species is disclosed. The sensor comprises an electrically insulated substrate which contains small pores passing completely through it. Electrodes consisting of metallic or semiconductor material are deposited onto the top surface of the substrate. In a first embodiment of the invention, an electrolyte is placed on the top surface of the substrate in such a manner as to create a gas or vapor permeable electrolyte layer on top of the electrodes. In a second embodiment of the invention, the electrolyte is applied to the bottom surface of the substrate and seeps up through the porous holes of the substrate until it makes contact with the electrodes. Both embodiments result in a gas sensor with a response time dependent upon the gas flow rate rather than the time required for the gas to be dissolved in the electrolyte layer and be detected.

    Abstract translation: 公开了一种用于气态和气态物质的传感器。 传感器包括一个电绝缘的基底,其中包含完全通过它的小孔。 由金属或半导体材料组成的电极沉积在基板的顶表面上。 在本发明的第一实施例中,电解质以在电极顶部产生气体或透气电解质层的方式被放置在基板的顶表面上。 在本发明的第二实施例中,将电解质施加到基底的底表面,并通过衬底的多孔孔渗透直到其与电极接触。 两个实施例都导致气体传感器具有取决于气体流速的响应时间,而不是气体溶解在电解质层中并被检测所需的时间。

    Method and apparatus for optically detecting presence of immunological
components
    6.
    发明授权
    Method and apparatus for optically detecting presence of immunological components 失效
    用于光学检测免疫组分存在的方法和装置

    公开(公告)号:US5169599A

    公开(公告)日:1992-12-08

    申请号:US576359

    申请日:1990-08-30

    Abstract: An optical immunosensing device for detecting the presence of an analyte in a liquid sample is fabricated by coating iron phosphate onto a silicon substrate and then etching the iron phosphate layer to obtain steps of varying thickness. Then, a first mip, capable of immunological reaction with the analyte, is immobilized on the iron phosphate steps. In the preferred embodiment, the first mip is chemically bound to the iron phosphate step surface. The presence of the analyte in the liquid sample is detected by visually observing color changes in the steps after contact of the detection zone with the liquid sample. A change in step color is related to increased thickness which can only result from the binding of the analyte to the first mip immobilized on the iron phosphate step. Aluminum phosphate can also be added to the iron phosphate.

    Abstract translation: 通过将磷酸铁涂覆到硅衬底上,然后蚀刻磷酸铁层以获得改变厚度的步骤来制造用于检测液体样品中分析物的存在的光学免疫感测装置。 然后,能够与分析物进行免疫反应的第一个mip被固定在磷酸铁步骤上。 在优选的实施方案中,第一絮凝剂化学键合到磷酸铁步骤表面。 通过目视观察检测区域与液体样品接触后的步骤中的颜色变化来检测液体样品中分析物的存在。 步骤颜色的改变与增加的厚度有关,这只能由分析物与固定在磷酸铁步骤上的第一个胶片结合而产生。 磷酸铝也可以添加到磷酸铁中。

    Sensor for electrochemical measurements
    9.
    发明授权
    Sensor for electrochemical measurements 失效
    电化学测量传感器

    公开(公告)号:US5489371A

    公开(公告)日:1996-02-06

    申请号:US37016

    申请日:1993-03-25

    CPC classification number: G01N33/2888

    Abstract: This invention relates to a sensor for the direct and continuous measurement of the electrochemical properties of compounds in a high resistivity liquid. The sensor has a housing which includes a porous hydrophilic membrane which may be made of a ceramic, and contains an electrolytic solution. The membrane permits the passage of a portion of the electrolytic solution into the pores thereby facilitating the formation of an interface between the electrolytic solution and the high resistivity liquid and allowing extraction of the compounds in the high resistivity liquid into the electrolytic solution. A porous sensing electrode is positioned directly on the membrane for detecting and measuring the concentration of the compounds extracted from the high resistivity fluid.

    Abstract translation: 本发明涉及用于直接和连续地测量化合物在高电阻率液体中的电化学性质的传感器。 传感器具有壳体,其包括可由陶瓷制成并包含电解液的多孔亲水膜。 膜允许一部分电解溶液进入孔中,从而便于在电解溶液和高电阻率液体之间形成界面,并允许将高电阻率液体中的化合物提取到电解液中。 多孔感应电极直接位于膜上,用于检测和测量从高电阻率流体提取的化合物的浓度。

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