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    Method for preparing an extract of ginkgo biloba leaves highly enriched in active principles
    4.
    发明授权
    Method for preparing an extract of ginkgo biloba leaves highly enriched in active principles 失效
    银杏叶提取物的制备方法高度富集活性成分

    公开(公告)号：US07048954B2

    公开(公告)日：2006-05-23

    申请号：US10472408

    申请日：2002-04-09

    申请人： Beng Poon Teng

    发明人： Beng Poon Teng

    IPC分类号： A61K35/78

    CPC分类号： A61K36/16

    摘要： A process for the preparation of an extract of Ginkgo biloba leaves, comprising i. extraction of the dried fragments of Ginkgo biloba leaves in ethanol containing a maximum of 20% by weight of water; ii. concentration of the extract under reduced pressure in the presence of an aqueous solution of sodium chloride and elimination of the dark oil from the remainder of the clear solution; iii. washing of the residual aqueous solution by liquid-liquid extraction with n-hexane, n-heptane or cyclohexane, iv. liquid-liquid extraction of the aqueous phase washed with ethyl acetate; and v. washing of the ethyl acetate phase obtained in stage iv with a sodium chloride solution followed by evaporation to dryness of the washed ethyl acetate phase and use of the resulting extract to treat cerebral and peripheral vascular disorders and neurodegenerative diseases.

    摘要翻译： 一种制备银杏提取物的方法，包括i。 在含有最多20重量％水的乙醇中提取银杏叶的干燥片段; ii。 在氯化钠水溶液存在下减压浓缩萃取物，并从澄清溶液的其余部分除去深色油状物; iii。 用正己烷，正庚烷或环己烷进行液 - 液萃取洗涤残余水溶液，iv。 用乙酸乙酯洗涤水相的液 - 液萃取; 和v。用氯化钠溶液洗涤在阶段iv中获得的乙酸乙酯相，然后蒸发至干洗的乙酸乙酯相，并使用得到的提取物来治疗脑和周围血管疾病和神经变性疾病。

    Pre-filled safety injection device with integrated waste collector
    7.
    发明授权
    Pre-filled safety injection device with integrated waste collector 有权
    带集成废料收集器的预填充安全注射装置

    公开(公告)号：US06953447B2

    公开(公告)日：2005-10-11

    申请号：US10278163

    申请日：2002-10-22

    申请人： Christophe Aubert ,  Roland Cherif-Cheikh

    发明人： Christophe Aubert ,  Roland Cherif-Cheikh

    IPC分类号： A61M5/315 ,  A61M5/32 ,  A61M5/00 ,  B65D83/10

    CPC分类号： A61M5/315 ,  A61M5/3205 ,  Y10S128/919

    摘要： The invention relates to a pre-filled injection device for injecting a liquid or semisolid composition into a subject, said injection device comprising: a housing (1) containing at its distal end the liquid or semisolid composition (2), a plunger (3) arranged to slide within the housing (1) to which is affixed a plunger stick (7) extending longitudinally from the plunger to the outside of the housing (1), a hollow needle (4) affixed to the distal end of the housing (1), said needle (4) connecting the interior part of the housing (1) with the outside where it extends longitudinally, and an airtight needle shield (5) which protects said needle (4), characterized in that said device further comprises a cap (6) designed to fit around the housing's proximal end and to fully cover said plunger stick (7), said cap (6) both preventing its accidental pushing or breakage before use and being adapted to receive the injection device once the injection into the subject has been carried out.

    摘要翻译： 本发明涉及一种用于将液体或半固体组合物注射到受试者中的预填充注射装置，所述注射装置包括：在其远端包含液体或半固体组合物（2）的壳体（1），柱塞（3） 布置成在所述壳体（1）内滑动，所述壳体（1）固定有从所述柱塞纵向延伸到所述壳体（1）的外部的柱塞杆（7），固定到所述壳体（1）的远端的中空针 ），所述针（4）将所述壳体（1）的内部与其纵向延伸的外部连接，以及保护所述针（4）的气密针护罩（5），其特征在于，所述装置还包括帽 （6），其被设计成围绕所述壳体的近端并且完全覆盖所述柱塞杆（7），所述盖（6）在使用之前都防止其意外推动或破裂，并且一旦注入到所述对象中就适于接收所述注射装置 已经开展

    Mikanolide derivatives, their preparation and therapeutic uses
    8.
    发明授权
    Mikanolide derivatives, their preparation and therapeutic uses 失效
    米考洛德衍生物，其制备和治疗用途

    公开(公告)号：US06887869B2

    公开(公告)日：2005-05-03

    申请号：US10250383

    申请日：2002-01-11

    申请人： Olivier Lavergne ,  Christophe Lanco ,  Grégoire Prevost ,  Beng Poon Teng

    发明人： Olivier Lavergne ,  Christophe Lanco ,  Grégoire Prevost ,  Beng Poon Teng

    IPC分类号： A61K31/34 ,  A61K31/343 ,  A61P9/10 ,  A61P13/08 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07D493/18 ,  C07D493/08 ,  C07D493/22

    CPC分类号： C07D493/18

    摘要： The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I)2, wherein: R1 represents H, SR4 or NR4R5; R2 represents SR6 or NR6R7; R3 represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18 or O(CO)NHR18, each of the radicals R4, R6, R15, R16 and R17 representing independently (in particular) an alkyl radical, the radicals R5 and R7 representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R14 and R18 representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1 does not represent a hydrogen atom

    摘要翻译： 本发明涉及新颖的米卡尼定衍生物，其制备方法及其治疗用途，特别是抗癌和抗病毒剂。 化合物对应于对应于通式（I）的通式（1）1和2其中：R 1 表示H，SR 4或NR 4 R 5; R 2表示SR 6或NR 6 R 7; R 3表示OH，O（CO）R 14，OSiR 15 R 16 R 17， O（CO）OR 18或O（CO）NHR 18，基团R 4，R 3， R 6，R 15，R 16和R 17独立地表示（特别是）烷基，基团R 时，R 1不表示氢原子