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    Method And System For Determining Plasma Protein Content Of Whole Blood Using Refractometry
    1.
    发明申请
    Method And System For Determining Plasma Protein Content Of Whole Blood Using Refractometry 有权

    公开(公告)号：US20230129832A1

    公开(公告)日：2023-04-27

    申请号：US17963527

    申请日：2022-10-11

    申请人： Terumo BCT, Inc.

    发明人： Dennis J. HLAVINKA ,  Thomas J. FELT

    IPC分类号： A61M1/34 ,  G01N21/41 ,  G01N21/85 ,  G01N21/03

    摘要： A method and system is provided that measures plasma protein levels of whole blood while a plasma donor is connected to an apheresis machine. A refractometer associated with the apheresis machine is capable of receiving a portion of a disposable tubing set including an integrated cuvette and prism. The integrated cuvette of the disposable tubing set can be inserted into a receiving space of the refractometer associated with the apheresis machine such that the light source and the sensor are oriented relative to the prism and a sensing surface of the integrated cuvette in a precise alignment. Calibration of the refractometer is made using anticoagulant pumped through the disposable tubing set including the integrated cuvette and prism. Based on a light intensity associated with this calibration, whole blood is then measured to determine plasma protein levels and donor eligibility.

    CELL CAPTURE AND EXPANSION
    4.
    发明申请
    CELL CAPTURE AND EXPANSION 有权

    公开(公告)号：US20220306978A1

    公开(公告)日：2022-09-29

    申请号：US17702658

    申请日：2022-03-23

    申请人： Terumo BCT, Inc.

    发明人： Mark E. Jones ,  Dalip Sethi ,  Dennis J. Hlavinka ,  Thomas J. Felt

    IPC分类号： C12M1/12 ,  A61K35/15 ,  C12M3/00 ,  C12M1/10 ,  C12N5/00 ,  C12N5/0789

    摘要： Implementations are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In implementations, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other implementations, the cells may be grown in co-culture with other cells, e.g., hMSC's. In implementations, the cells may include CD34+ cells. A coated membrane includes a membrane having a first coating configured to promote cellular adhesion to the membrane and a second coating that includes a soluble protein moiety.

    Centrifugal Cassette with Molded Insertable Valves
    5.
    发明申请
    Centrifugal Cassette with Molded Insertable Valves 有权

    公开(公告)号：US20220112967A1

    公开(公告)日：2022-04-14

    申请号：US17430434

    申请日：2020-02-26

    申请人： Terumo BCT, Inc.

    发明人： Randy PEERY ,  James LADTKOW ,  Jesse JANZEN ,  Andrew GLOOR ,  Kevin KLIMEK

    IPC分类号： F16K99/00 ,  B04B5/04 ,  B29C45/00

    摘要： Provided is a centrifuge cassette assembly (800) for separating a fluid and related method of manufacture. The cassette assembly includes a first chamber, a second chamber (308), a fluidic channel (808) creating a fluid connection between the first chamber and the second chamber, at least one molded insertion valve (600, 700) configured to control the flow of fluid in the fluidic channel and a heating element (802) for actuating the at least one molded valve. Further provided are Normally Open Valves (NOVs) (700) and Normally Closed Valves (NCVs) (600) which are capable of insertion into, and which control the fluid flow of, the centrifuge cassette assembly.

    Fluid Control and Bypass Features for an Apheresis System
    6.
    发明申请
    Fluid Control and Bypass Features for an Apheresis System 有权

    公开(公告)号：US20210361850A1

    公开(公告)日：2021-11-25

    申请号：US17394182

    申请日：2021-08-04

    申请人： Terumo BCT, Inc.

    发明人： Brian M. HOLMES ,  Thomas J. FELT ,  Taylor POLODNA

    IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M1/02 ,  A61M1/38 ,  A61M1/30

    摘要： Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

    CELL EXPANSION
    7.
    发明申请
    CELL EXPANSION 有权

    公开(公告)号：US20210047602A1

    公开(公告)日：2021-02-18

    申请号：US17087571

    申请日：2020-11-02

    申请人： Terumo BCT, Inc.

    发明人： Boah VANG ,  Brian J. NANKERVIS ,  Mark E. JONES

    IPC分类号： C12M1/00 ,  C12N5/0783

    摘要： Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.