摘要:
A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.
摘要:
A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable oil, mineral oil and/or a lower alcohol such that the formed microspheres demonstrate intracellular bioactivity when taken up by macrophages.
摘要:
FIG. 1 is a perspective view of a stent showing our new design; FIG. 2 is another perspective view thereof; FIG. 3 is front view thereof; FIG. 4 is a rear view thereof; FIG. 5 is a right-hand view thereof; FIG. 6 is a left-hand view thereof; FIG. 7 is a top view thereof; FIG. 8 is a bottom view thereof; FIG. 9 is another front view thereof; and, FIG. 10 is a cross-sectional view along each of lines 10-10 shown in FIG. 9. The broken lines illustrate portions of the patmas lantern stent that form no part of the claimed design.
摘要:
A transdermal delivery system of microneedles containing a bioactive material, comprising at least one layer of a support material; at least one biodegradable needle associated with the support material, each needle comprising at least one biodegradable polymer and at least one sugar, wherein each biodegradable needle is hollow and is adapted to retain a bioactive material.
摘要:
Provided are alternative splicing constructs and methods for their use. In particular, CD44 based alternative splicing constructs are provided that include CD44 exon 5. These alternative splicing constructs are useful in high-throughput assays for testing the effects of compounds on splicing and for achieving targeted cell death.
摘要:
Prosthetic devices containing an artificial foot are disclosed. Methods of making and using prosthetic devices containing an artificial foot are also disclosed. The artificial foot may be in the form of a thermoformed foot member having at least one foot member curved section between a foot member first end and a foot member second end opposite the foot member first end such that (a) a first portion of a foot member inner surface overlaps and faces a second portion of the foot member inner surface, (b) a foot member second end surface is positioned (i) between and connecting a foot member outer surface and the foot member inner surface to one another and (ii) over and facing the foot member second end surface along the at least one foot member curved section.
摘要:
Embodiments provide for health related inquires, such as inquiries for information about a drug, disease, or other condition, to be received and responses to the inquiries to be delivered to the requester. The inquiries may be submitted electronically and the response may likewise be returned electronically. It may be determined whether the requester is a healthcare provider or a patient and the formulation of the response proceeds based on which type of requester submitted the inquiry. Delivery characteristics may be specified for the inquiry such as the delivery type and a timeframe for delivery. An account may be provided for requesters to provide information including a default delivery type and credentials to establish the requester type. Additional features may be provided including newsfeed subscriptions related to the inquiry to provide ongoing information subsequent to the submission of the inquiry.
摘要:
A system and method for cleaning or removing coatings, such as paint, from a surface with a stream of particles. A carbon dioxide (CO.sub.2) pelletizer forms carbon dioxide pellets, which are delivered by a delivery system against a surface to be cleaned. The delivery system includes a hopper for containing the pellets and a high pressure air supply. A feeder introduces the pellets from the hopper into the high pressure air. The combined high pressure air and pellets are directed along a delivery hose to a nozzle, which directs the air and pellets against a surface to be cleaned. Temperature sensors are provided to monitor the temperature of the pressurized air at various points in the delivery system. Signals from the temperature sensor are provided in a feedback control manner to a control valve. The control valve controls the introduction of liquid nitrogen (N.sub.2) into the air stream at a mixing chamber in the delivery system. In accordance with the invention, the temperature sensors and feedback controls permit maintenance of the temperature of the high pressure air below the sublimation temperature of the pellets as the pellets are delivered by the delivery system, thereby prolonging the life of the pellets and reducing sublimation prior to ejection from the nozzle.
摘要:
Compounds, such as cathinone derivatives, and pharmaceutical formulations that include the compounds. The compounds may have a first selectivity for a first receptor subtype that is at least 10 times greater than a second selectivity for a second receptor subtype from the same class of receptors. Methods of treating patients, which may include administering to a patient a pharmaceutical formulation that includes a compound, such as a cathinone derivative.
摘要:
FIG. 1 is a perspective frontal view of a Patmas weave stent showing our new design; FIG. 2 is a right-hand view thereof; FIG. 3 is a left-hand view thereof; FIG. 4 is front view thereof; FIG. 5 is a rear view thereof; FIG. 6 is a top view thereof; FIG. 7 is a bottom view thereof; FIG. 8 is another right-hand view thereof; FIG. 9 is a cross-sectional view along line 9-9 shown in FIG. 8; FIG. 10 is a cross-sectional view along line 10-10 shown in FIG. 8; FIG. 11 is a cross-sectional view along line 11-11 shown in FIG. 8; and, FIG. 12 is a cross-sectional view along line 12-12 shown in FIG. 8. The broken lines illustrate portions of the Patmas weave stent that form no part of the claimed design.