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1.发明公开公开(公告)号：US20230277471A1
公开(公告)日：2023-09-07
申请号：US18126251
申请日：2023-03-24
IPC分类号： A61K9/51 , A61K9/127 , A61K31/12 , A61K31/137 , A61K31/19 , A61K31/546 , A61K31/7034 , A61K31/713 , A61K38/14 , A61K38/28 , A61K39/29 , A61K39/395 , A61K45/06
CPC分类号： A61K9/51 , A61K9/127 , A61K9/1275 , A61K31/12 , A61K31/137 , A61K31/19 , A61K31/546 , A61K31/7034 , A61K31/713 , A61K38/14 , A61K38/28 , A61K39/29 , A61K39/3955 , A61K45/06
摘要： The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
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公开(公告)号：US10349820B2
公开(公告)日：2019-07-16
申请号：US13808463
申请日：2011-07-12
摘要： The present invention may be embodied as a retrievable device capable of sensing one or more properties of an individual (e.g., chemical or physical parameters, etc.) In use, the retrievable device can continuously determine the chemical concentrations within the vaginal tract. An embodiment of the retrievable device comprises a first housing having a light source and an image capture device, a second housing removably connected to the first housing and having a sensor, and a fitting for retrieving the device. The sensor may be an analyte sensor configured to obtain at least one measurement of a concentration of an analyte in a fluid. The analyte sensor comprises a sensor substance in a sol-gel material so the sensor substance reversibly interacts with an analyte of interest. In addition, the retrievable device can be configured to determine different physical parameters and re-implanted.
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公开(公告)号：US20130237774A1
公开(公告)日：2013-09-12
申请号：US13808453
申请日：2011-07-07
IPC分类号： A61B5/07 , A61B1/04 , A61B1/00 , A61B5/00 , A61B7/00 , A61B1/06 , A61B5/1459 , A61B5/145 , A61B5/03
CPC分类号： A61B5/073 , A61B1/00009 , A61B1/00011 , A61B1/00147 , A61B1/041 , A61B1/0661 , A61B1/2736 , A61B5/0004 , A61B5/036 , A61B5/067 , A61B5/14507 , A61B5/14532 , A61B5/14539 , A61B5/1459 , A61B5/4283 , A61B7/008
摘要： The present invention may be embodied as an ingestible device capable of sensing one or more chemical parameters. In use, the device can continuously determine the chemical concentrations within an alimentary canal tract. An embodiment of the device comprises a housing resistant to degradation by alimentary canal fluid, a light source, and image capture device. An analyte sensor is configured to obtain at least one measurement of a concentration of analyte in the fluid. The analyte sensor comprises a sensor substance in a sol-gel material so the sensor substance reversibly interacts with an analyte of interest. In addition, the analyte sensor is configured to generate a trigger signal for controlling the operation of subsystems in the device.
摘要翻译： 本发明可以被实施为能够感测一个或多个化学参数的可摄取装置。 在使用中，该装置可以连续地确定消化道内的化学物质浓度。 该装置的一个实施例包括抵抗由消化道液体降解的外壳，光源和图像捕获装置。 分析物传感器被配置为获得流体中分析物浓度的至少一个测量。 分析物传感器包括溶胶 - 凝胶材料中的传感器物质，因此传感器物质与感兴趣的分析物可逆地相互作用。 此外，分析物传感器被配置为产生用于控制设备中的子系统的操作的触发信号。
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公开(公告)号：US20130225922A1
公开(公告)日：2013-08-29
申请号：US13808463
申请日：2011-07-12
IPC分类号： A61B1/04
CPC分类号： A61B1/041 , A61B1/00186 , A61B1/043 , A61B1/051 , A61B1/0684 , A61B1/303 , A61B5/07 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/435
摘要： The present invention may be embodied as a retrievable device capable of sensing one or more properties of an individual (e.g., chemical or physical parameters, etc.) In use, the retrievable device can continuously determine the chemical concentrations within the vaginal tract. An embodiment of the retrievable device comprises a first housing having a light source and an image capture device, a second housing removably connected to the first housing and having a sensor, and a fitting for retrieving the device. The sensor may be an analyte sensor configured to obtain at least one measurement of a concentration of an analyte in a fluid. The analyte sensor comprises a sensor substance in a sol-gel material so the sensor substance reversibly interacts with an analyte of interest. In addition, the retrievable device can be configured to determine different physical parameters and re-implanted.
摘要翻译： 本发明可以实施为能够感测个体的一个或多个性质（例如，化学或物理参数等）的可回收装置。在使用中，可回收装置可以连续地确定阴道内的化学浓度。 可回收装置的实施例包括具有光源和图像捕获装置的第一壳体，可移除地连接到第一壳体并具有传感器的第二壳体和用于检索装置的配件。 传感器可以是配置成获得流体中分析物浓度的至少一个测量的分析物传感器。 分析物传感器包括溶胶 - 凝胶材料中的传感器物质，因此传感器物质与感兴趣的分析物可逆地相互作用。 此外，可检索设备可以被配置为确定不同的物理参数并重新植入。
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5.发明授权公开(公告)号：US12005146B2
公开(公告)日：2024-06-11
申请号：US18126251
申请日：2023-03-24
IPC分类号： A61K9/51 , A61K9/127 , A61K31/12 , A61K31/137 , A61K31/19 , A61K31/546 , A61K31/7034 , A61K31/713 , A61K38/14 , A61K38/28 , A61K39/29 , A61K39/395 , A61K45/06
CPC分类号： A61K9/51 , A61K9/127 , A61K9/1275 , A61K31/12 , A61K31/137 , A61K31/19 , A61K31/546 , A61K31/7034 , A61K31/713 , A61K38/14 , A61K38/28 , A61K39/29 , A61K39/3955 , A61K45/06
摘要： The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
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6.发明授权公开(公告)号：US11633364B2
公开(公告)日：2023-04-25
申请号：US17337283
申请日：2021-06-02
IPC分类号： A61K9/51 , A61K9/127 , A61K31/12 , A61K31/137 , A61K31/19 , A61K31/546 , A61K31/7034 , A61K31/713 , A61K38/14 , A61K38/28 , A61K39/29 , A61K39/395 , A61K45/06
摘要： The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
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公开(公告)号：US20220400937A1
公开(公告)日：2022-12-22
申请号：US17893727
申请日：2022-08-23
摘要： The present invention may be embodied as a retrievable device capable of sensing one or more properties of an individual (e.g., chemical or physical parameters). In use, the retrievable device can continuously determine the chemical concentrations within the vaginal tract. An embodiment of the retrievable device comprises a first housing having a light source and an image capture device, a second housing removably connected to the lust housing and having a sensor, and a fitting for retrieving the device. The sensor may be an analyte sensor configured to obtain at least one measurement of a concentration of an analyte in a fluid. The analyte sensor comprises a sensor substance in a sol-gel material so the sensor substance reversibly interacts with an analyte of interest. In addition, the retrievable device can be configured to determine different physical parameters and re-implanted.
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公开(公告)号：US11737976B2
公开(公告)日：2023-08-29
申请号：US16119931
申请日：2018-08-31
发明人： Mary P. McCourt
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1277 , A61K38/1709 , A61K38/1761 , A61K38/45 , A61K38/482 , A61K47/10 , A61K47/28 , C12Y207/11001 , C12Y304/21078 , C12Y304/21079
摘要： The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size. In some embodiments, the plurality of cholesteryl esters include at least two different cholesteryl esters, and in some of these embodiments, the at least two different cholesteryl esters are selected from the group consisting of cholesteryl myristate, cholesteryl laurate, cholesteryl dodeconate, cholesteryl palmitate, cholesteryl arachidonate, cholesteryl behenate, cholesteryl linoleate, cholesteryl linolenate, cholesteryl oleate and cholesteryl stearate.
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公开(公告)号：US10369114B2
公开(公告)日：2019-08-06
申请号：US15603992
申请日：2017-05-24
IPC分类号： A61K9/51 , A61K31/7034 , A61K31/713 , A61K31/12 , A61K31/137 , A61K31/19 , A61K38/14 , A61K38/28 , A61K45/06 , A61K39/29 , A61K39/395 , A61K31/546 , A61K9/127
摘要： The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
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10.发明申请Method and System to Provide Personalized Pharmaceutical Compositions and Dosages 有权提供个性化药物组合物和剂量的方法和系统公开(公告)号：US20140037739A1
公开(公告)日：2014-02-06
申请号：US13754855
申请日：2013-01-30
IPC分类号： A61K31/7004 , G06F19/00
CPC分类号： G06F19/3431 , A61K31/7004 , A61K45/06 , G01N33/66 , G01N2800/042 , G01N2800/52 , G06F19/00 , G16H50/30 , Y10T436/104998 , Y10T436/105831 , Y10T436/144444
摘要： Provided is a method for assessing cardiovascular risk in Metabolic Syndrome and Type 2 Diabetes patients. The method involves obtaining data from a Type 2 diabetes patient or a Metabolic Syndrome patient and determining a Fayad/Schentag index which includes a Glucose Supply Index (S) to an Insulin Demand Index (D) ratio. The Fayad/Schentag index is used in scoring cardiovascular risks of Metabolic Syndrome patients and for recommending and implementing therapeutic interventions that can be shown to lower cardiovascular risk
摘要翻译： 提供了一种评估代谢综合征和2型糖尿病患者心血管风险的方法。 该方法包括从2型糖尿病患者或代谢综合征患者获得数据，并确定Fayad / Schentag指数，其包括胰岛素需求指数（D）比率的葡萄糖供应指数（S）。 Fayad / Schentag指数用于评估代谢综合征患者的心血管风险，并用于推荐和实施可显示降低心血管风险的治疗干预措施
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