公开(公告)号：US09297808B2

公开(公告)日：2016-03-29

申请号：US13805017

申请日：2011-05-31

申请人： Joel Louette ,  John Charles Rogers

发明人： Joel Louette ,  John Charles Rogers

IPC分类号： C12Q1/37 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/68 ,  B82Y15/00 ,  G01N33/532 ,  H01J49/00

CPC分类号： G01N33/6848 ,  B82Y15/00 ,  C07K2/00 ,  G01N30/7233 ,  G01N30/8665 ,  G01N30/8675 ,  G01N33/532 ,  G01N33/68 ,  G01N2458/15 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  Y10T436/25 ,  Y10T436/25125

摘要： Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

公开(公告)号：US08933396B2

公开(公告)日：2015-01-13

申请号：US13805059

申请日：2011-07-07

申请人： Joel Louette ,  John Charles Rogers ,  Scott M. Peterman ,  Bruno Domon ,  Elodie Duriez

发明人： Joel Louette ,  John Charles Rogers ,  Scott M. Peterman ,  Bruno Domon ,  Elodie Duriez

IPC分类号： G01N33/68 ,  C07K2/00 ,  G01N33/532 ,  B82Y15/00

CPC分类号： G01N33/6848 ,  B82Y15/00 ,  C07K2/00 ,  G01N30/7233 ,  G01N30/8665 ,  G01N30/8675 ,  G01N33/532 ,  G01N33/68 ,  G01N2458/15 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  Y10T436/25 ,  Y10T436/25125

摘要： Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

摘要翻译： 在使用与报告物偶联的标记肽的质谱法和通用报道分子中，分析物的定量，包括但不限于肽，多肽和蛋白质。

公开(公告)号：US11328915B2

公开(公告)日：2022-05-10

申请号：US16857117

申请日：2020-04-23

申请人： Thermo Fisher Scientific GmbH

发明人： Johannes Schwieters ,  Henning Wehrs ,  Jamie Lewis

IPC分类号： H01J49/26 ,  H01J49/10 ,  H01J49/00 ,  H01J49/14 ,  H01J49/04 ,  H01J49/06 ,  H01J49/42

摘要： A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.

公开(公告)号：US09377469B2

公开(公告)日：2016-06-28

申请号：US14579206

申请日：2014-12-22

申请人： Joel Louette ,  John Charles Rogers ,  Scott M. Peterman ,  Bruno Domon ,  Elodie Duriez

发明人： Joel Louette ,  John Charles Rogers ,  Scott M. Peterman ,  Bruno Domon ,  Elodie Duriez

IPC分类号： G01N33/68 ,  G01N33/58 ,  C07K2/00 ,  B82Y15/00 ,  G01N33/532 ,  H01J49/00

CPC分类号： G01N33/6848 ,  B82Y15/00 ,  C07K2/00 ,  G01N30/7233 ,  G01N30/8665 ,  G01N30/8675 ,  G01N33/532 ,  G01N33/68 ,  G01N2458/15 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  Y10T436/25 ,  Y10T436/25125

摘要： Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

公开(公告)号：US09945867B2

公开(公告)日：2018-04-17

申请号：US14927586

申请日：2015-10-30

申请人： Thermo Fisher Scientific GMBH

发明人： Joel Louette ,  John Charles Rogers ,  Scott M. Peterman ,  Bruno Domon ,  Elodie Duriez

IPC分类号： G01N30/72 ,  H01J49/00 ,  B82Y15/00 ,  G01N33/68 ,  G01N33/532 ,  C07K2/00 ,  G01N30/86

CPC分类号： G01N33/6848 ,  B82Y15/00 ,  C07K2/00 ,  G01N30/7233 ,  G01N30/8665 ,  G01N30/8675 ,  G01N33/532 ,  G01N33/68 ,  G01N2458/15 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  Y10T436/25 ,  Y10T436/25125

摘要： Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.