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公开(公告)号：US20210284612A1
公开(公告)日：2021-09-16
申请号：US17315969
申请日：2021-05-10
发明人： Karen Annette DUGGAN
IPC分类号： C07D233/64 , C07D241/04 , A61P9/00 , A61P13/12 , A61P11/00 , C07D233/90 , C07D401/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/04 , C07D413/04 , C07D413/06 , C07D403/06 , C07D407/04 , C07D417/06 , C07D407/06 , C07D409/06 , C07D409/04 , A61P1/16 , A61P9/12
摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
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公开(公告)号：US10752578B2
公开(公告)日：2020-08-25
申请号：US15761862
申请日：2016-09-21
发明人： Anthony Kaye , Nurul Quazi , George Feast , Marshnil Lakshman
IPC分类号： C07C231/02 , C07C309/66 , C07C69/732 , C07C59/52 , C07C303/28 , C07C231/12 , C07C235/34 , C07C51/09 , C07C53/134 , C07C67/03 , C07C67/31 , C07C69/616
摘要： The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I or intermediates thereof.
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公开(公告)号：US10035775B2
公开(公告)日：2018-07-31
申请号：US15557762
申请日：2016-03-18
发明人： Karen Annette Duggan
IPC分类号： C07D233/78 , C07C39/12 , C07C59/54 , C07C215/54 , C07C239/20 , C07D207/26 , C07D207/38 , C07D209/48 , C07D233/96 , C07D261/14 , C07D263/38 , C07D263/44
摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.
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公开(公告)号：US20180037539A1
公开(公告)日：2018-02-08
申请号：US15558155
申请日：2016-03-18
发明人： Karen Annette DUGGAN
IPC分类号： C07C235/34 , C07H15/203 , C07D231/12 , C07D333/24 , C07C237/20 , C07D213/56
CPC分类号： C07C235/34 , C07C237/20 , C07D207/327 , C07D213/56 , C07D231/12 , C07D239/26 , C07D261/08 , C07D277/30 , C07D307/54 , C07D333/24 , C07H15/203
摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of kidney and/or liver disease.
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公开(公告)号：US10919863B2
公开(公告)日：2021-02-16
申请号：US16319957
申请日：2017-07-28
发明人： Karen Annette Duggan
IPC分类号： C07D239/26 , A61P11/00 , C07C39/15 , C07C215/54 , C07C233/11 , C07D207/408 , C07D213/56 , C07D237/08 , C07D261/14 , C07D263/44 , C07D277/30 , C07D401/10 , C07D403/10 , C07D333/24 , C07C233/07 , C07D231/56 , C07D235/26 , C07D235/06 , C07C59/52 , C07C275/42 , C07D213/73 , C07D277/68 , A61P11/06 , C07D231/12 , C07C211/29 , C07D207/38 , C07C255/00 , C07C271/28 , C07C217/48 , C07C261/04 , C07D241/12 , C07D309/10 , C07D233/78 , C07D261/08 , C07D209/48 , C07C237/20 , C07D207/327 , C07C237/22 , C07D307/54 , C07D249/18 , C07D209/34 , C07D263/38 , C07C307/10 , C07D207/26 , C07D207/444 , C07C235/34 , C07C311/03 , C07C311/08 , C07C239/20 , C07C235/78 , C07D209/18 , C07D263/58 , C07D215/14 , C07D207/40 , A61K45/06
摘要： The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
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公开(公告)号：US07951777B2
公开(公告)日：2011-05-31
申请号：US11629041
申请日：2005-06-10
申请人： Karen A. Duggan
发明人： Karen A. Duggan
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： A61K38/2278
摘要： The present invention is concerned with composition and methods for treatment of certain cardiovascular conditions. In particular it is concerned with prophylactic or therapeutic treatment of myocardial fibrosis or associated conditions by administering compositions comprising vasoactive intestinal peptide (VIP) and/or active fragments) thereof.
摘要翻译： 本发明涉及用于治疗某些心血管疾病的组合物和方法。 特别地，它涉及通过施用包含血管活性肠肽（VIP）和/或其活性片段的组合物来预防或治疗心肌纤维化或相关病症。
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公开(公告)号：US11834417B2
公开(公告)日：2023-12-05
申请号：US17315969
申请日：2021-05-10
发明人： Karen Annette Duggan
IPC分类号： C07D233/64 , C07D241/04 , A61P9/00 , A61P13/12 , A61P11/00 , C07D233/90 , C07D401/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/04 , C07D413/04 , C07D413/06 , C07D403/06 , C07D407/04 , C07D417/06 , C07D407/06 , C07D409/06 , C07D409/04 , A61P1/16 , A61P9/12
CPC分类号： C07D233/64 , A61P1/16 , A61P9/00 , A61P9/12 , A61P11/00 , A61P13/12 , C07D233/90 , C07D241/04 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
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公开(公告)号：US20190270712A1
公开(公告)日：2019-09-05
申请号：US16319957
申请日：2017-07-28
发明人： Karen Annette DUGGAN
IPC分类号： C07D239/26 , C07D237/08 , C07D213/56 , C07D277/30 , C07C233/11 , C07D263/44 , C07C215/54 , C07D207/408 , C07D261/14 , C07D401/10 , C07D403/10 , C07C39/15 , A61P11/00
摘要： The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
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公开(公告)号：US09732136B2
公开(公告)日：2017-08-15
申请号：US15132475
申请日：2016-04-19
发明人： Karen Annette Duggan
IPC分类号： A61K38/10 , C07K14/575 , A61K38/08 , A61K45/06 , C07K7/06 , C07K7/08 , A61K38/22 , A61K38/00
CPC分类号： C07K14/57563 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/2278 , A61K45/06 , C07K7/06 , C07K7/08
摘要： The invention relates to composition comprising a pharmaceutically effective amount of one or more functional vasoactive intestinal peptide (VIP) fragments, and the use of those compositions in the treatment of fibrosis, hypertension and other disorders.
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公开(公告)号：US09458093B2
公开(公告)日：2016-10-04
申请号：US15022278
申请日：2014-09-17
发明人： Karen Annette Duggan
IPC分类号： C07C235/34 , A61K31/165
CPC分类号： C07C235/34 , A61K31/165
摘要： The present invention relates to a novel terphenyl compound and its use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
摘要翻译： 本发明涉及一种新颖的三联苯化合物及其在预防和/或治疗高血压和/或纤维化中的用途。
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