公开(公告)号：US12116407B2

公开(公告)日：2024-10-15

申请号：US17269991

申请日：2019-09-25

申请人： Academia Sinica

发明人： Shie-Liang Hsieh ,  Pei-Shan Sung ,  Ming-Ting Huang ,  An-Suei Yang ,  Chung-Ming Yu

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  A61P31/20

CPC分类号： C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

摘要： Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.

公开(公告)号：US12109317B2

公开(公告)日：2024-10-08

申请号：US17564096

申请日：2021-12-28

申请人： NATIONAL CHENG KUNG UNIVERSITY

发明人： Ping-Ching Wu ,  Cheng-Hsin Chuang ,  Po-Heng Chen ,  Yu-Yi Chiang

IPC分类号： A61K9/70 ,  A61K9/16 ,  A61K31/573 ,  A61K35/15 ,  A61K35/33 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  A61L27/38 ,  A61L27/56 ,  C08L29/04 ,  C08L67/04 ,  D01D5/00 ,  D01F1/10 ,  A61P17/02

CPC分类号： A61K9/70 ,  A61K31/573 ,  A61K35/15 ,  A61K35/33 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  C08L29/04 ,  C08L67/04 ,  D01D5/0015 ,  D01F1/10 ,  A61P17/02 ,  C08L2203/02 ,  C08L2203/12

摘要： Disclosed herein are electrospun fibrous matrix and its production method. The method mainly includes the steps of, mixing a first polymer and a drug to form a first mixture, and sonicating the first mixture until a plurality of microparticles are formed with the drug encapsulated therein; and mixing the plurality of microparticles with a second polymer to form a second mixture, subjecting the second mixture to a wet electrospinning process to form the electrospun fibrous matrix. The thus-produced electrospun fibrous matrix is characterized by having a plurality of first and second fibrils woven together, in which each second fibril has a plurality of drug-encapsulated microparticles independently integrated and disposed along the longitudinal direction of the second fibril. Also disclosed herein is a method for treating a wound of a subject. The method includes applying the present electrospun fibrous matrix to the wound of the subject.

公开(公告)号：US12108937B2

公开(公告)日：2024-10-08

申请号：US17312890

申请日：2019-05-21

申请人： INNOVEX MEDICAL CO., LTD

发明人： Hang Yan ,  Wei Tang ,  Zimei Zhang ,  Ruifeng Gao

IPC分类号： A61B1/005 ,  A61B1/06 ,  H05K1/18

CPC分类号： A61B1/005 ,  A61B1/0615 ,  H05K1/182 ,  H05K1/189 ,  H05K2201/10106

摘要： A detection package structure-includes an exterior tube; a detection assembly, a flexible printed circuit (FPC), a module base, and lighting members which are all disposed inside the exterior tube. The FPC includes a main flexible plate and minor flexible plates. The invention uses detection conductive materials and detection wiring parts to implement electric conduction-directed soldering, whereby to prevent from direct soldering of cables and detection assembly and enlarge soldering spots.

公开(公告)号：US12094973B2

公开(公告)日：2024-09-17

申请号：US17874954

申请日：2022-07-27

申请人： TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.

发明人： Chun-Yuan Chen ,  Huan-Chieh Su ,  Pei-Yu Wang ,  Chih-Hao Wang

IPC分类号： H01L29/78 ,  H01L21/8234 ,  H01L27/088 ,  H01L29/06 ,  H01L29/417 ,  H01L29/66

CPC分类号： H01L29/785 ,  H01L21/823431 ,  H01L27/0886 ,  H01L29/0649 ,  H01L29/41791 ,  H01L29/66795 ,  H01L2029/7858

摘要： Embodiments of the present disclosure provide a method for forming backside metal contacts with reduced Cgd and increased speed. Particularly, source/drain features on the drain side, or source/drain features without backside metal contact, are recessed from the backside to the level of the inner spacer to reduce Cgd. Some embodiments of the present disclosure use a sacrificial liner to protect backside alignment feature during backside processing, thus, preventing shape erosion of metal conducts and improving device performance.

公开(公告)号：US12075990B2

公开(公告)日：2024-09-03

申请号：US17044218

申请日：2019-03-07

申请人： ACCU TARGET MEDIPHARMA (SHANGHAI) CO., LTD.

发明人： Qi Li ,  Binkai Xu ,  Jinting Liu ,  Kaiqiang Chang ,  Xiangtong Chang

IPC分类号： A61B10/02

CPC分类号： A61B10/0275 ,  A61B10/0283 ,  A61B2010/0208

摘要： The present invention provides a biopsy rotary cutting device, which comprises a dynamic sealing structure(4) arranged outside an inner cutting cannula(3); the dynamic sealing structure(4) forms a cavity outside the inner cutting cannula(3); the inner cutting cannula(3) comprises a first tube section(31) and a second tube section(32) that are arranged in sequence along the axial direction of the inner cutting cannula(3); the outer diameter of the second tube section(32) is smaller than that of the first tube section(31); a sealing ring(43) is arranged inside the dynamic sealing structure(4); the cavity comprises a first cavity(41) and a second cavity(42); when the inner cutting cannula(3) moves to a first position along its axial direction, the sealing ring(43) is located at the outer side of the second tube section(32); and there is an inter-cavity gap(46) between the sealing ring(43) and the second tube section(32) to realize communication between the first cavity(41) and the second cavity(42). The present invention can introduce the atmosphere to form a circulating air flow with better suction strength, and the circulating air flow can more efficiently send a rotary-cut tissue at a corresponding position to a sample collector at the back end, thereby effectively improving the sample discharge rate.

公开(公告)号：US12070135B2

公开(公告)日：2024-08-27

申请号：US18243105

申请日：2023-09-07

申请人： Wonderland Switzerland AG

发明人： Zhiren Zhong

IPC分类号： A47D9/00

CPC分类号： A47D9/005

摘要： A child bassinet includes a standing frame including a first leg having two first side segments and a second leg having two second side segments, a top rail portion and a linkage assembly. The top rail portion includes a first rail connected with a second rail via two articulations, the first rail being connected pivotally with the two first side segments and the second rail being connected pivotally with the two second side segments at locations that are spaced apart from the two articulations. The linkage assembly includes two first linking parts each of which having two opposite ends respectively connected pivotally with one of the two first side segments and one of the two articulations, and two second linking parts each of which having two opposite ends respectively connected pivotally with one of the two second side segments and one of the two articulations.

公开(公告)号：US12068372B2

公开(公告)日：2024-08-20

申请号：US18118010

申请日：2023-03-06

申请人： TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.

发明人： Chih-Ching Wang ,  Kuan-Lun Cheng ,  Wen-Hsing Hsieh

IPC分类号： H01L29/08 ,  H01L21/768 ,  H01L21/8234 ,  H01L23/528 ,  H01L23/532 ,  H01L27/088 ,  H01L27/092 ,  H01L29/06 ,  H01L29/417 ,  H01L29/423

CPC分类号： H01L29/0847 ,  H01L21/76846 ,  H01L23/528 ,  H01L23/53209 ,  H01L29/0653 ,  H01L29/41791 ,  H01L29/4236 ,  H01L2924/13067

摘要： A semiconductor device structure, along with methods of forming such, are described. In one embodiment, a semiconductor device structure is provided. The semiconductor device structure includes a substrate having a front side and a back side opposing the front side, a gate stack disposed on the front side of the substrate, and a first source/drain feature and a second source/drain feature disposed in opposing sides of the gate stack. Each first source/drain feature and second source/drain feature comprises a first side and a second side, and a portion of the back side of the substrate is exposed to an air gap.

公开(公告)号：US12064466B2

公开(公告)日：2024-08-20

申请号：US17730195

申请日：2022-04-27

申请人： Academia Sinica

发明人： Hsin-Fang Yang-Yen

IPC分类号： A61K38/17 ,  A61P3/06

CPC分类号： A61K38/1709 ,  A61P3/06

摘要： The present invention is directed to methods of treating hypertriglyceridemia or hypertriglyceridemia-related diseases in a subject by using recombinant PRAP1 polypeptides. According to some embodiments of the present disclosure, the subject is a human, in which the recombinant PRAP1 polypeptide comprises the amino acid sequence 100% identical to SEQ ID NO: 1 or 2. According to certain embodiments of the present disclosure, the subject is a mouse, in which the recombinant PRAP1 polypeptide comprises the amino acid sequence 100% identical to SEQ ID NO: 3 or 4.

公开(公告)号：US12062612B2

公开(公告)日：2024-08-13

申请号：US18118372

申请日：2023-03-07

申请人： TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.

发明人： Shu-Wei Li ,  Guanyu Luo ,  Shin-Yi Yang ,  Ming-Han Lee

IPC分类号： H01L23/528 ,  H01L21/768 ,  H01L23/522 ,  H01L23/532

CPC分类号： H01L23/5283 ,  H01L21/76843 ,  H01L23/5225 ,  H01L23/5226 ,  H01L23/53238

摘要： An interconnection structure, along with methods of forming such, are described. The structure includes a dielectric material and a conductive feature extending through the dielectric material. The conductive feature includes a conductive material and has a first top surface. The structure further includes a dummy conductive feature disposed adjacent the conductive feature in the dielectric material, and the dummy conductive feature has a second top surface substantially co-planar with the first top surface. An air gap is formed in the dummy conductive feature.

公开(公告)号：US12059983B2

公开(公告)日：2024-08-13

申请号：US17955349

申请日：2022-09-28

申请人： Bambino Prezioso Switzerland AG

发明人： Ruyi Li ,  Da Liang Zhang

IPC分类号： B60N2/80 ,  B60N2/28

CPC分类号： B60N2/2839 ,  B60N2/2821 ,  B60N2/2851 ,  B60N2/2869

摘要： A child safety seat includes a seat shell, a front end part rotatable relative to the seat shell between a retracted and a deployed position, and a latching mechanism for locking the front end part in the deployed position. The seat shell has a front end provided with an opening, and two sidewalls respectively protruding at a left and a right side of a seat portion. The front end part has a transversal portion extending along a width direction of the seat shell, and two side portions respectively connected pivotally with the two sidewalls of the seat shell via two pivot shafts spaced apart from each other along the width direction. The transversal portion of the front end part is stowed inside the opening of the seat shell in the retracted position, and extends outside the opening of the seat shell in the deployed position.