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1.发明授权Method of showing progression of AIDS in an ARC patient by treating with Tyr-Gly compositions 失效用Tyr-Gly组合物治疗ARC患者AIDS进展情况的方法
公开(公告)号：US5081108A
公开(公告)日：1992-01-14
申请号：US469779
申请日：1990-01-24
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
CPC分类号： A61K39/39 , A61K35/15 , C07K4/12 , C07K5/06026 , C07K5/06121 , C07K5/0812 , G01N33/50 , A61K2039/55516 , A61K2039/55588 , A61K38/00
摘要： Purified human leukocyte dialysates are described for treatment of AIDS, ARC, and other immunodeficient conditions. The dialysates are purified by HPLC processes, and are made available in a form that is free of endotoxin and pyrogen. Methods are described for slowing the progression from ARC to AIDS and for alleviating symptoms of AIDS and ARC, by administration of the dialysates. Methods for treating candidiasis and for increasing immune system response to recall antigen, by administration of the dialysates, are also described.
摘要翻译： 描述纯化的人白细胞透析液用于治疗AIDS，ARC和其他免疫缺陷状况。 透析液通过HPLC方法纯化，并且以不含内毒素和热原的形式提供。 描述了通过施用透析液来减缓从ARC到AIDS的进展和减轻艾滋病和ARC的症状的方法。 还描述了通过施用透析液治疗念珠菌病和增加免疫系统对召回抗原的反应的方法。
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2.发明授权Methods for modulating antibody production in treating patients with AIDS, ARC and other diseases 失效用于调节抗体产生的方法，用于治疗AIDS，ARC等疾病
公开(公告)号：US5013546A
公开(公告)日：1991-05-07
申请号：US501973
申请日：1990-03-29
IPC分类号： A61K38/04
CPC分类号： A61K38/04
摘要： Methods and compositions are described for increasing and decreasing immunoglobulin production by administering to a human or other mammalian subject an appropriate dosage of amplifier. Administration of amplifier to subjects having excessive production of immunoglobulin, namely AIDS and ARC patients, is shown as decreasing such excessive immunoglobulin production in such patients.
摘要翻译： 描述了通过向人或其他哺乳动物受试者施用适当剂量的放大器来增加和减少免疫球蛋白产生的方法和组合物。 对于具有过量产生免疫球蛋白的受试者（即艾滋病和ARC患者）的放大器的给药显示为在这些患者中减少这种过量的免疫球蛋白产生。
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公开(公告)号：US4876193A
公开(公告)日：1989-10-24
申请号：US832016
申请日：1986-02-24
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
CPC分类号： G01N33/6866 , C12Q1/18 , G01N33/5091 , Y10S435/948
摘要： Methods are described for assaying, in vitro, the capacity of a subject's lymphocytes to manifest suppressor function. PBLs are exposed to an agent stimulating suppressor cell formation and/or activation. Other PBLs are treated to induce a cell proliferative response, thereby producing responder cells. The responder cells are subjected to an antigen in the presence of the suppressor cells previously produced and in the presence of various concentrations of an amplifier. The procedure provides a means of ascertaining suppressor capacity of the subject's immune system, i.e., the subject's potential to express suppressor function, thereby permitting assay of severity of autoimmune disease, titrating dosage of immunomodulatory agents, and determining whether modulator therapy is feasible.
摘要翻译： 描述了用于在体外测定受试者淋巴细胞显示抑制功能的能力的方法。 PBL暴露于刺激抑制细胞形成和/或激活的药剂。 治疗其他PBL以诱导细胞增殖反应，从而产生应答细胞。 在先前产生的抑制细胞和各种浓度的放大器的存在下，应答细胞经受抗原。 该方法提供了确定受试者的免疫系统的抑制能力的方法，即受试者表达抑制功能的潜力，从而允许测定自身免疫疾病的严重性，免疫调节剂的滴定剂量，以及确定调节剂治疗是否可行。
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公开(公告)号：US4774176A
公开(公告)日：1988-09-27
申请号：US650218
申请日：1984-09-13
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
IPC分类号： C12N15/00 , C12Q1/68 , G01N33/574 , G01N33/543 , G01N33/566
CPC分类号： G01N33/574 , C12N15/00 , C12Q1/6886 , Y10S435/803 , Y10S435/81 , Y10S436/808 , Y10S436/813
摘要： A more convenient, more sensitive test for detection of certain malignancies in human and animal subjects is disclosed. Sera from test subjects is mixed with labeled DNA in the presence of an enzyme-conjugated matrix. Sera from normal and cancerous subjects react differently with the matrix, permitting a diagnosis of the subject.
摘要翻译： 公开了用于检测人和动物受试者中某些恶性肿瘤的更方便，更灵敏的检测方法。 来自测试受试者的血清与标记的DNA在酶共轭基质的存在下混合。 来自正常和癌症受试者的血清与基质反应不同，允许对受试者进行诊断。
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公开(公告)号：US4699898A
公开(公告)日：1987-10-13
申请号：US813632
申请日：1985-12-26
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
CPC分类号： C12Q1/04 , A61K39/39 , C07K5/00 , C07K5/0812 , A61K2039/55516 , A61K38/00
摘要： A tripeptide and derivatives thereof are described that amplify mammalian immune response. A purification process, methods of using, and pharmaceutical compositions for using the product are disclosed.
摘要翻译： 描述了三肽及其衍生物，其扩增哺乳动物的免疫应答。 公开了一种净化方法，使用方法和用于使用该产品的药物组合物。
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公开(公告)号：US4490472A
公开(公告)日：1984-12-25
申请号：US389381
申请日：1982-06-17
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
IPC分类号： C12N11/00 , C12N15/00 , C12Q1/00 , C12Q1/68 , G01N21/64 , G01N33/574 , C07H15/12 , G01N33/50
CPC分类号： G01N33/574 , C12N15/00 , C12Q1/6886 , Y10S436/804 , Y10S436/813 , Y10S436/815
摘要： An improved, more convenient, more sensitive test for detection of certain malignancies in human and animal subjects is disclosed. Sera from test subjects is mixed with labeled DNA in the presence of an enzyme-conjugated resin. Sera from normal and cancerous subjects react differently with the resin, permitting a diagnosis of the subject.
摘要翻译： 公开了用于检测人和动物受试者中某些恶性肿瘤的改进的，更方便的，更灵敏的检测方法。 在酶共轭树脂的存在下，将来自测试受试者的血清与标记的DNA混合。 来自正常和癌症受试者的血清与树脂的反应不同，允许对受试者进行诊断。
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公开(公告)号：US4710380A
公开(公告)日：1987-12-01
申请号：US848210
申请日：1986-04-04
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
CPC分类号： A61K38/05 , A61K35/15 , A61K38/06 , Y10S424/81 , Y10S514/885
摘要： Therapeutic methods for treatment of rheumatoid arthritis, lupis, Type I diabetes, and other autoimmune disorders are described wherein amplifiers of the immune system response are administered to the subject. Instead of further increasing the hyperactive immune response, however, administering the amplifiers has the effect of reducing the excessive immune responsiveness. Compositions for such administration are also described.
摘要翻译： 描述了用于治疗类风湿性关节炎，狼疮，I型糖尿病和其它自身免疫性疾病的治疗方法，其中向受试者施用免疫系统应答的放大器。 然而，代替进一步增加过度免疫应答，施用放大器具有降低过度免疫反应性的作用。 还描述了用于这种施用的组合物。
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公开(公告)号：US4468379A
公开(公告)日：1984-08-28
申请号：US441432
申请日：1982-11-15
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
CPC分类号： A61K45/05 , A61K35/15 , B01D61/243 , A61K35/14 , B01D15/325 , B01D2311/06 , B01D2311/26 , B01D2311/2649
摘要： A group of substances derived from human leukocytes (white blood cells) are described that amplify, suppress, or otherwise modulate the response of the immune system to reintroduction of antigens. The described materials are generically effective as to antigens rather than specific as to particular antigens, but the described modulators of immune response are effective only in respect of antigens with which the recipient has previously been challenged. The described materials are extracted from leukocyte dialysates by processes involving high pressure liquid chromatography with specified resin/solvent systems. Uses and pharmaceutical compositions for use of the materials are also described.
摘要翻译： 描述了衍生自人白细胞（白细胞）的一组物质，其扩增，抑制或以其他方式调节免疫系统对再次引入抗原的反应。 所描述的材料对于抗原而言通常是有效的，而不是针对特定抗原的特异性，但是所述的免疫应答的调节剂仅在接受者先前被攻击的抗原方面是有效的。 所述材料通过涉及具有特定树脂/溶剂体系的高压液相色谱法的过程从白细胞透析液中提取。 还描述了用于使用该材料的用途和药物组合物。
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公开(公告)号：US4920097A
公开(公告)日：1990-04-24
申请号：US256581
申请日：1988-10-12
CPC分类号： A61K35/15 , Y10S530/829
摘要： Methods of extracting an immunosuppressor from leukocyte dialysates are disclosed, together with methods for using the immunosuppressor and compositions containing the immunosuppressor.
摘要翻译： 公开了从白细胞透析液中提取免疫抑制剂的方法，以及使用免疫抑制剂的方法和含有免疫抑制剂的组合物。
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公开(公告)号：US4874608A
公开(公告)日：1989-10-17
申请号：US43175
申请日：1987-04-27
申请人： A. Arthur Gottlieb
发明人： A. Arthur Gottlieb
摘要： A method is described for treating mammalian solid tumors by administering leukocyte-derived amplifiers of the immune system to tumor-bearing subjects. The amplifiers include Beta-1.0, Beta-1.1, Beta-1,12, TG, and TGG.
摘要翻译： 描述了一种通过将免疫系统的白细胞衍生的放大器施用于荷瘤患者来治疗哺乳动物实体瘤的方法。 放大器包括Beta-1.0，Beta-1.1，Beta-1,12，TG和TGG。
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