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    Method of measuring cell-substrate impedance in living cells to identify compounds affecting receptor tyrosine kinase (RTK) activity and pathways
    2.
    发明授权
    Method of measuring cell-substrate impedance in living cells to identify compounds affecting receptor tyrosine kinase (RTK) activity and pathways 有权

    公开(公告)号：US10168318B2

    公开(公告)日：2019-01-01

    申请号：US15613052

    申请日：2017-06-02

    申请人： ACEA Biosciences, Inc.

    发明人： Yama A. Abassi ,  Naichen Yu ,  Josephine Atienza ,  Xiao Xu ,  Xiaobo Wang

    IPC分类号： G01N33/50 ,  C12Q1/00 ,  G01N27/02 ,  G01N33/543

    摘要： A method of identifying a potential therapeutic compound that affects a Receptor Tyrosine Kinase (RTK) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a RTK pathway and a RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells.

    Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
    6.
    发明授权
    Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases 有权
    吡咯并[2,3-d]嘧啶化合物作为蛋白激酶的抑制剂

    公开(公告)号：US09586965B2

    公开(公告)日：2017-03-07

    申请号：US14420341

    申请日：2013-07-11

    申请人： ACEA BIOSCIENCES INC.

    发明人： Xiao Xu ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P35/00 ,  A61P29/00 ,  A61P17/06

    CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.

    摘要翻译： 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗增殖紊乱和与激酶失调相关的其它疾病的方法（例如但不限于EGFR（包括HER ），Alk，PDGFR，BLK，BMX / ETK，BTK，FLT3（D835Y），ITK，JAK1，JAK2，JAK3，TEC和TXK）和/或各自的途径。

    NOVEL PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
    7.
    发明申请
    NOVEL PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES 有权
    作为蛋白激酶抑制剂的新型吡咯烷酮化合物

    公开(公告)号：US20150210702A1

    公开(公告)日：2015-07-30

    申请号：US14420341

    申请日：2013-07-11

    申请人： ACEA BIOSCIENCES INC.

    发明人： Xiao Xu ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

    IPC分类号： C07D487/04 ,  A61K31/519

    CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.

    摘要翻译： 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗增殖紊乱和与激酶失调相关的其它疾病的方法（例如但不限于EGFR（包括HER ），Alk，PDGFR，BLK，BMX / ETK，BTK，FLT3（D835Y），ITK，JAK1，JAK2，JAK3，TEC和TXK）和/或各自的途径。

    OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE
    8.
    发明申请
    OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 有权
    流量计，光流量计系统的光学发动机及其使用方法

    公开(公告)号：US20150140577A1

    公开(公告)日：2015-05-21

    申请号：US14547963

    申请日：2014-11-19

    申请人： ACEA Biosciences, Inc.

    发明人： Nan Li ,  Ye Chen ,  Hyunsun Chung ,  Zengqiang Li ,  Xiaobo Wang

    IPC分类号： G01N15/14 ,  G01N33/569 ,  G01N21/64

    CPC分类号： G01N21/645 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/6486 ,  G01N33/56972 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1438 ,  G01N2015/1477 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/06113

    摘要： An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.

    摘要翻译： 一种用于台式流式细胞仪的光学引擎，该光学引擎包括一组激光器; 用于每个激光器的不同组的光束整形光学器件，其中每个组件包括两个透镜，用于可调节地将光沿x轴水平地聚焦到相同的水平位置，并且沿着y轴沿着同一平面垂直地垂直于不同的垂直位置; 用于从流动池收集荧光的收集光学器件; 过滤光学器件，根据波长范围将从流通池收集的荧光过滤到不同的检测通道; 以及用于将滤波后的荧光转换为电信号的每个检测通道的检测器，其中对电信号进行处理，使得来自不同垂直位置处的每个激光的荧光在相同的检测器处被区分。

    HETEROCYCLIC COMPOUNDS AND USES THEREOF
    9.
    发明申请
    HETEROCYCLIC COMPOUNDS AND USES THEREOF 有权
    杂环化合物及其用途

    公开(公告)号：US20150133457A1

    公开(公告)日：2015-05-14

    申请号：US14329890

    申请日：2014-07-11

    申请人： ACEA BIOSCIENCES INC.

    发明人： Xiao XU ,  Xiaobo WANG ,  Long MAO ,  Li ZHAO ,  Biao XI

    IPC分类号： C07D487/04 ,  C07D239/49 ,  C07D417/12 ,  C07D401/12 ,  C07D473/18 ,  C07D239/52 ,  C07D403/12

    CPC分类号： C07D519/00 ,  C07D239/47 ,  C07D239/48 ,  C07D239/49 ,  C07D239/52 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D473/18 ,  C07D487/04

    摘要： The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

    摘要翻译： 本发明涉及药物化合物，组合物和方法，特别是因为它们与用于治疗和/或预防增殖病症，癌症，肿瘤，炎性疾病，自身免疫性疾病，牛皮癣，干性疾病的组合物和方法有关 眼睛或免疫相关疾病，在一些实施方案中，与激酶失调相关的疾病或病症，例如但不限于EGFR（包括HER），Alk，PDGFR，BLK，BMX / ETK，FLT3（D835Y），ITK ，TEC，TXK，BTK或JAK，以及各自的途径。

    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL
    10.
    发明申请
    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 有权
    用于检测流动通道中的多激发诱导光的系统和方法

    公开(公告)号：US20130200277A1

    公开(公告)日：2013-08-08

    申请号：US13657845

    申请日：2012-10-22

    申请人： ACEA BIOSCIENCES, INC

    发明人： Nan Li ,  Jian Wu ,  Ye Chen ,  Tianxing Wang ,  Xiaobo Wang

    IPC分类号： G01N21/64

    CPC分类号： G01N21/645 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/64 ,  G01N21/6428 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/06113 ,  G01N2201/0621

    摘要： A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    摘要翻译： 一种用于检测由多个激发源引起的光的信号分量的系统，包括：流路，包括至少两个空间分离的光询问区; 非调制激励源，其将第一波长的光束以接近恒定的强度引导到第一光学询问区上; 调制激励源，其将以调制频率随时间调制的第二波长的光束引导到第二光学询问区上; 检测器子系统，包括一组检测器，其被配置为检测从流过所述至少两个光询问区的颗粒发射的光并将检测到的光转换成总电信号; 以及处理器，其根据从每个光询问区检测的光来确定信号分量。