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公开(公告)号：US09518069B2
公开(公告)日：2016-12-13
申请号：US14796370
申请日：2015-07-10
发明人： Ireneusz Kownacki , Bogdan Marciniec , Beata Dudziec , Agnieszka Kownacka , Mariusz Majchrzak , Mateusz Szulc , Bartosz Orwat
CPC分类号： C07F7/0827 , C07F7/0805 , C07F7/081 , C07F7/0838 , C07F7/0876 , C07F7/0896 , C07F7/10 , C07F7/1804 , C07F7/1876 , C07F7/188 , C07F7/1892 , C07F13/00 , C07F17/02
摘要： New (triorganosilyl)alkynes and their derivatives having general formula R1—C≡C—Z are provided along with methods for the preparation of (triorganosilyl)alkynes and their derivatives having the general formula R1—C≡C—Z. The methods may include silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine.
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2.发明申请2', 5' -DIDEOXY-5-FLUOROURIDINE DERIVATIVES HAVING CYTOTOXIC ACTIVITY, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF 有权具有细胞毒活性的2'，5'-二氧代-5-氟尿嘧啶衍生物，其制备方法及其应用公开(公告)号：US20160244473A1
公开(公告)日：2016-08-25
申请号：US14413618
申请日：2014-03-04
IPC分类号： C07H19/06
CPC分类号： C07H19/06 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072
摘要： The subject matter of the invention is novel 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1. wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms.In a second aspect, the subject matter of the invention is a process for the manufacture of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1.In a third aspect, the subject matter of the invention is an application of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译： 本发明的主题是通式1的新的2'，5'-二脱氧-5-氟尿苷衍生物。其中R1表示在C-8和C-9原子具有确定的绝对构型的cinchona生物碱片段。 在第二方面，本发明的主题是制备通式1的2'，5'-二脱氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题是 2'，5'-二脱氧-5-氟尿苷衍生物在乳癌，宫颈癌，肺癌和鼻咽癌的抗癌治疗中的应用。
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公开(公告)号：US09249167B1
公开(公告)日：2016-02-02
申请号：US14677125
申请日：2015-04-02
发明人： Dawid Frackowiak , Patrycja Żak , Bogdan Marciniec
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： A new cage monovinylgermasilsesquioxanes of the general formula 1, in which R1 are the same and represent a C1 to C6 alkyl group or a cyclopentyl or cyclohexyl group or a phenyl group. The invention also relates to the method of synthesis of cage monovinylgermasilsesquioxanes of the general formula 1.
摘要翻译： 一种通式1的新型笼型单乙烯基硅氧烷倍半硅氧烷，其中R 1相同并且表示C1-C6烷基或环戊基或环己基或苯基。 本发明还涉及通式1的笼式单乙烯基倍半硅氧烷的合成方法。
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公开(公告)号：US20160022668A1
公开(公告)日：2016-01-28
申请号：US14430168
申请日：2014-03-04
发明人： Lech CELEWICZ , Karol KACPRZAK , Piotr RUSZKOWSKI
IPC分类号： A61K31/49
CPC分类号： A61K31/49
摘要： 9-O-propargyl ethers of cinchona alkaloids of general formula represented by formula 1 wherein respective ethers have the following absolute configuration at C-8 and C-9 atoms: (8R,9S)—cinchonine configuration or (8R,9R)—9-epicinchonine configuration are useful in treatments of at least one of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译： 由式1表示的通式生物碱的9-O-炔丙基醚，其中相应的醚在C-8和C-9原子具有以下绝对构型：（8R，9S） - 嘧啶醌构型或（8R，9R）-9 至少一种乳腺癌，宫颈癌，肺癌和鼻咽癌的治疗有用。
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公开(公告)号：US20190144636A1
公开(公告)日：2019-05-16
申请号：US16313823
申请日：2017-06-29
发明人： Hector RODRIGUEZ MARTINEZ , Ana Maria SOTO CAMPOS , Olga STOLARSKA , Marcin SMIGLAK , Anna PAWLOWSKA
摘要： Mixtures of salts to dissolve cellulose. The present invention refers to a composition based in a eutectic mixture of imidazolium salts and natural biopolymers, in particular cellulose, its manufacturing process and method of use to obtain foils or films.The composition is based in a eutectic mixture of imidazolium salts with 0.1 to 50 wt % of biomass.
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6.发明申请2,3'-ANHYDRO-2'-DEOXY-5-FLUOROURIDINE DERIVATIVES WITH CYTOTOXIC ACTIVITY, A MANUFACTURING PROCESS AND APPLICATION 有权具有细胞毒活性的2,3'-壬基-2'-脱氧-5-氟尿嘧啶衍生物，制造方法和应用公开(公告)号：US20160024133A1
公开(公告)日：2016-01-28
申请号：US14420487
申请日：2014-08-22
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , A61K33/42 , C07F9/24 , C07F9/6561 , C07H19/073
摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1 -difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1.In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译： 本发明的主题是通式1的2,3' - 脱氢-2'-脱氧-5-氟尿苷衍生物，其中R是三氟甲基，2,2,2-三氟乙基，二氟甲基，全氟乙基，1-氟乙基， 2-氟乙基，1,1-二氟乙基，1,2-二氟乙基，2,2-二氟乙基，1,1,2-三氟乙基，1,2,2-三氟乙基，1,1,2,2-四氟乙基， 2,2,2-四氟乙基。 在第二方面，本发明的主题是制备通式1的2,3-脱水-2'-脱氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题是 在抗癌治疗乳腺癌，宫颈癌，肺癌和鼻咽癌中应用通式1的2,3'-脱氢-2'-脱氧-5-氟尿苷衍生物。
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![Application of 7-carboxybenzo[1,2,3]thiadiazole amides as plant stimulants](/abs-image/US/2021/05/18/US11006632B2/abs.jpg.150x150.jpg)
公开(公告)号：US11006632B2
公开(公告)日：2021-05-18
申请号：US15747622
申请日：2016-07-27
发明人： Marcin Śmiglak , Henryk Pospieszny , Rafal Kukawka , Piotr Lewandowski , Olga Stolarska , Hieronim Maciejewski
IPC分类号： A01N43/82 , A01N43/653
摘要： Disclosed herein are amide 7-carboxybenzo[1,2,3]thiadiazoles and derivatives thereof having a general Formula I, as described herein. Combinations and compositions of these compounds are also disclosed. The compounds and compositions can be used as a plant stimulant. For example, the compounds compositions can be used to regulate the plant's growth, regulate the plant's metabolic processes, regulate the plant's physiological processes, prevent against effects of biotic stress in the plant, or prevent against effects of abiotic stress in the plant. In some embodiments, the composition can provide multiple disease resistance to plants infected with a fungus, virus, or bacteria.
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8.发明授权公开(公告)号：US09301956B2
公开(公告)日：2016-04-05
申请号：US14430168
申请日：2014-03-04
发明人： Lech Celewicz , Karol Kacprzak , Piotr Ruszkowski
IPC分类号： A61K31/49
CPC分类号： A61K31/49
摘要： 9-O-propargyl ethers of cinchona alkaloids of general formula represented by formula 1 wherein respective ethers have the following absolute configuration at C-8 and C-9 atoms: (8R,9S)-cinchonine configuration or (8R,9R)-9-epicinchonine configuration are useful in treatments of at least one of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译： 由式1表示的通式生物碱的9-O-炔丙基醚，其中相应的醚在C-8和C-9原子具有以下绝对构型：（8R，9S） - 嘧啶醌构型或（8R，9R）-9 至少一种乳腺癌，宫颈癌，肺癌和鼻咽癌的治疗有用。
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9.发明授权2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application 有权具有细胞毒活性的2,3'-脱水-2'-脱氧-5-氟尿苷衍生物，制备方法和应用公开(公告)号：US09260468B1
公开(公告)日：2016-02-16
申请号：US14420487
申请日：2014-08-22
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , A61K33/42 , C07F9/24 , C07F9/6561 , C07H19/073
摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1.In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译： 本发明的主题是通式1的2,3' - 脱氢-2'-脱氧-5-氟尿苷衍生物，其中R是三氟甲基，2,2,2-三氟乙基，二氟甲基，全氟乙基，1-氟乙基， 2-氟乙基，1,1-二氟乙基，1,2-二氟乙基，2,2-二氟乙基，1,1,2-三氟乙基，1,2,2-三氟乙基，1,1,2,2-四氟乙基， 2,2,2-四氟乙基。 在第二方面，本发明的主题是制备通式1的2,3'-脱氢-2'-脱氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题 是在乳癌，宫颈癌，肺癌和鼻咽癌的抗癌治疗中应用通式1的2,3'-脱氢-2'-脱氧-5-氟尿苷衍生物。
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10.发明授权Functionalized unsaturated double-decker derivatives of divinylsilsesquioxanes 有权二乙烯基倍半硅氧烷的官能化不饱和双层衍生物公开(公告)号：US09150596B2
公开(公告)日：2015-10-06
申请号：US14640618
申请日：2015-03-06
发明人： Marciniec Bogdan , Dudziec Beata , Zak Patrycja
IPC分类号： C07F7/21
CPC分类号： C07F7/21
摘要： The subject of the invention are new functionalized unsaturated double-decker derivatives of divinylsilsesquioxanes of the general formula 1. In the formula, R1 are the same and stand for an aryl group containing from 1 to 2 rings, R2 are the same and stand for an alkyl group containing carbon atoms from C1 to C2, substituted or unsubstituted aryl group containing from 1 to 2 rings, R3 are the same and stand for a substituted or unsubstituted aryl group containing from 1 to 2 rings or a group of the formula —R4-R5—, where R4 stands for an alkyl group containing carbon atoms from C1 to C3, while R5 stands for aryl group containing from 1 to 2 rings.
摘要翻译： 本发明的主题是通式1的二乙烯基倍半硅氧烷的新的官能化不饱和双层甲基衍生物。在该式中，R 1相同，代表含有1至2个环的芳基，R 2相同并代表 含C1至C2的碳原子的烷基，含有1-2个环的取代或未取代的芳基，R3相同，代表含有1至2个环的取代或未取代的芳基或式-R4- R5-，其中R4代表含有C1至C3的碳原子的烷基，R5代表含有1至2个环的芳基。
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