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公开(公告)号：US11008403B2
公开(公告)日：2021-05-18
申请号：US15525821
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
摘要： The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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公开(公告)号：US11008383B2
公开(公告)日：2021-05-18
申请号：US16215523
申请日：2018-12-10
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20210130813A1
公开(公告)日：2021-05-06
申请号：US17087350
申请日：2020-11-02
申请人： Adimab, LLC
IPC分类号： C12N15/10 , C07K16/00 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US20140364340A1
公开(公告)日：2014-12-11
申请号：US14150129
申请日：2014-01-08
申请人： ADIMAB, LLC
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译： 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开可得到的人抗体序列数据库的合理设计。
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公开(公告)号：US10889811B2
公开(公告)日：2021-01-12
申请号：US16126987
申请日：2018-09-10
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US11008568B2
公开(公告)日：2021-05-18
申请号：US16236259
申请日：2018-12-28
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US10196635B2
公开(公告)日：2019-02-05
申请号：US14256126
申请日：2014-04-18
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US20170362339A1
公开(公告)日：2017-12-21
申请号：US15525791
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , G01N33/573 , A61K47/68 , A61K39/00
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12Y304/23046 , G01N33/573 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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公开(公告)号：US20160244750A1
公开(公告)日：2016-08-25
申请号：US15151626
申请日：2016-05-11
申请人： Adimab, LLC
IPC分类号： C12N15/10 , C07K16/00 , G01N33/543
CPC分类号： C12N15/1089 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08 , C40B50/02 , C40B50/06 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US10882920B2
公开(公告)日：2021-01-05
申请号：US15525791
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , A61K47/68 , A61K39/00 , G01N33/573
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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