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公开(公告)号：US11008383B2
公开(公告)日：2021-05-18
申请号：US16215523
申请日：2018-12-10
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20210130813A1
公开(公告)日：2021-05-06
申请号：US17087350
申请日：2020-11-02
申请人： Adimab, LLC
IPC分类号： C12N15/10 , C07K16/00 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US20210087271A1
公开(公告)日：2021-03-25
申请号：US17024749
申请日：2020-09-18
申请人： Adimab, LLC
IPC分类号： C07K16/28
摘要： The present invention provides Fc variants and polypeptides, e.g., antibodies and Fc fusion proteins, comprising such Fc variants. In particular, Fc variants with diminished effector function as a consequence of hinge region and CH2 domain mutations, e.g., LALE-PG, are provided. Such variants maintain antigen-binding and favorable developability profiles and may display improved expressability.
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公开(公告)号：US20140364340A1
公开(公告)日：2014-12-11
申请号：US14150129
申请日：2014-01-08
申请人： ADIMAB, LLC
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译： 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开可得到的人抗体序列数据库的合理设计。
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5.发明授权公开(公告)号：US11542330B2
公开(公告)日：2023-01-03
申请号：US16611832
申请日：2018-05-08
申请人： Adimab, LLC
IPC分类号： C07K16/28
摘要： Anti-CD3 binding domains and antibodies comprising them, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, and methods for their preparation and use. Reagents for identifying, isolating, selecting, generating and characterizing CD3 binding domains and antibodies comprising them are also provided.
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公开(公告)号：US20220396622A1
公开(公告)日：2022-12-15
申请号：US17848808
申请日：2022-06-24
申请人： ADIMAB, LLC
IPC分类号： C07K16/28
摘要： The present invention provides Fc variants and polypeptides, e.g., antibodies and Fc fusion proteins, comprising such Fc variants. In particular, Fc variants with diminished effector function as a consequence of hinge region and CH2 domain mutations, e.g., LALE-PG, are provided. Such variants maintain antigen-binding and favorable developability profiles and may display improved expressability.
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公开(公告)号：US10889811B2
公开(公告)日：2021-01-12
申请号：US16126987
申请日：2018-09-10
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US20190203205A1
公开(公告)日：2019-07-04
申请号：US16236259
申请日：2018-12-28
申请人： Adimab, LLC
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US10189894B2
公开(公告)日：2019-01-29
申请号：US14150129
申请日：2014-01-08
申请人： ADIMAB, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US10138478B2
公开(公告)日：2018-11-27
申请号：US15151626
申请日：2016-05-11
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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