公开(公告)号：US20090088450A1

公开(公告)日：2009-04-02

申请号：US11658923

申请日：2005-08-18

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Albert Dordal Zueras ,  Lus Romero Alonso ,  Hulmut Henrich Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Albert Dordal Zueras ,  Lus Romero Alonso ,  Hulmut Henrich Buschmann

IPC: A61K31/472 ,  C07D217/18

CPC classification number: C07D513/04 ,  C07D217/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20070021398A1

公开(公告)日：2007-01-25

申请号：US11457730

申请日：2006-07-14

Applicant: Antoni TORRENS ,  Jordi QUINTANA ,  Helmut BUSCHMANN ,  Albert DORDAL ,  Josep MAS

Inventor： Antoni TORRENS ,  Jordi QUINTANA ,  Helmut BUSCHMANN ,  Albert DORDAL ,  Josep MAS

IPC: A61K31/551 ,  A61K31/55 ,  A61K31/506 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/416 ,  A61K31/415 ,  C07D403/02 ,  C07D455/02 ,  A61K31/4709

CPC classification number: C07D231/06 ,  C07D401/12 ,  C07D403/12 ,  C07D495/04

Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。

公开(公告)号：US20070009597A1

公开(公告)日：2007-01-11

申请号：US10566402

申请日：2004-07-29

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Albert Dordal Zueras ,  Xavier Codony Soler ,  Ramon Merce Vidal ,  Jose-Aurello Castillo Perez ,  Jordi Frigola Constansa ,  Helmut-Heinrich Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Albert Dordal Zueras ,  Xavier Codony Soler ,  Ramon Merce Vidal ,  Jose-Aurello Castillo Perez ,  Jordi Frigola Constansa ,  Helmut-Heinrich Buschmann

IPC: A61K39/395 ,  A61K31/538 ,  A61K31/445 ,  A61K31/405 ,  A61K9/22

CPC classification number: A61K45/06

Abstract: The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity, preferably neuropeptide Y5-receptor affinity, and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

Abstract translation: 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物，优选神经肽Y5-受体亲和力的活性物质组合物和至少一种具有5-HT 6受体亲和力的化合物，药物 包括所述活性物质组合，以及所述活性物质组合用于制备药物的用途。

公开(公告)号：US20110160181A1

公开(公告)日：2011-06-30

申请号：US13036533

申请日：2011-02-28

Applicant: ANTONI TORRENS ,  JORDI QUINTANA ,  HELMUT BUSCHMANN ,  ALBERT DORDAL ,  JOSEP MAS

Inventor： ANTONI TORRENS ,  JORDI QUINTANA ,  HELMUT BUSCHMANN ,  ALBERT DORDAL ,  JOSEP MAS

IPC: A61K31/4155 ,  A61P25/00 ,  A61P37/00 ,  A61P9/00 ,  A61P5/00 ,  A61P11/00 ,  A61P1/00 ,  A61P3/10 ,  A61P25/18 ,  A61P25/32 ,  A61P25/34 ,  A61P25/30 ,  A61P3/04 ,  A61P35/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/08 ,  A61P9/10 ,  A61P25/06 ,  A61P27/06 ,  A61P25/16 ,  A61P25/28 ,  A61P11/06 ,  A61P1/08 ,  A61P1/12 ,  A61P19/10 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/496 ,  A61K31/4725 ,  A61K31/473

CPC classification number: C07D231/06 ,  C07D401/12 ,  C07D403/12 ,  C07D495/04

Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。

公开(公告)号：US07897589B2

公开(公告)日：2011-03-01

申请号：US11457730

申请日：2006-07-14

Applicant: Antoni Torrens ,  Jordi Quintana ,  Helmut Buschmann ,  Albert Dordal ,  Josep Mas

Inventor： Antoni Torrens ,  Jordi Quintana ,  Helmut Buschmann ,  Albert Dordal ,  Josep Mas

IPC: A61K31/551 ,  A61K31/55 ,  A61K31/506 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/416 ,  A61K31/415 ,  A61K31/4709 ,  C07D403/02 ,  C07D455/02

CPC classification number: C07D231/06 ,  C07D401/12 ,  C07D403/12 ,  C07D495/04

Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。

公开(公告)号：US08207156B2

公开(公告)日：2012-06-26

申请号：US13036533

申请日：2011-02-28

Applicant: Antoni Torrens ,  Jordi Quintana ,  Helmut Buschmann ,  Albert Dordal ,  Josep Mas

Inventor： Antoni Torrens ,  Jordi Quintana ,  Helmut Buschmann ,  Albert Dordal ,  Josep Mas

IPC: A61K31/397 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/473 ,  A61K31/4725 ,  A61K31/454 ,  A61K31/4155

CPC classification number: C07D231/06 ,  C07D401/12 ,  C07D403/12 ,  C07D495/04

Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。