公开(公告)号：US08798701B2

公开(公告)日：2014-08-05

申请号：US12571145

申请日：2009-09-30

Applicant: Kurtulus Izzetoglu ,  Kambiz Pourrezaei ,  Banu Onaral ,  Jay Charles Horrow ,  Meltem Alkan Izzetoglu ,  Scott C. Bunce

Inventor： Kurtulus Izzetoglu ,  Kambiz Pourrezaei ,  Banu Onaral ,  Jay Charles Horrow ,  Meltem Alkan Izzetoglu ,  Scott C. Bunce

IPC: A61B5/1455 ,  A61M16/00

CPC classification number: A61B5/14552 ,  A61B5/14553 ,  A61B5/4821 ,  A61B5/7203 ,  A61B2562/0233 ,  A61B2562/046

Abstract: Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a patient. The optical density change may be used to obtain a change in deoxyhemoglobin (deoxy-Hb) concentration and/or a change in an oxyhemoglobin concentration (oxy-Hb). The changes in the deoxy-Hb and/or the oxy-Hb may then be compared to determine a state of anesthesia.The effect of artifacts (e.g., strong surgery room lighting, patient-table tilting, patient intubation/extubation) on the fNIR signal may be removed using a noise removal algorithm. In selecting the noise removal algorithm, a switching technique may be used to select the component analysis algorithm, such as a principal component analysis (PCA), an independent component analysis (ICA), or the like.

Abstract translation: 公开了用于以非侵入性方式测量麻醉状态的方法和装置。 可以使用光学技术来测量功能性近红外（fNIR）信号的变化，其中响应于在患者的近红外范围内引导波长的波长而接收fNIR信号。 可以使用光密度变化来获得脱氧血红蛋白（脱氧-Hb）浓度的变化和/或氧合血红蛋白浓度（oxy-Hb）的变化。 然后可以比较脱氧-Hb和/或氧-Hb的变化以确定麻醉状态。 可以使用噪声去除算法去除伪影（例如，强手术室照明，患者台倾斜，患者插管/拔管）对fNIR信号的影响。 在选择噪声去除算法时，可以使用切换技术来选择分量分析算法，例如主分量分析（PCA），独立分量分析（ICA）等。

公开(公告)号：US08602557B2

公开(公告)日：2013-12-10

申请号：US13310026

申请日：2011-12-02

Applicant: Stanley Huth ,  Denise Tran ,  Huawei Zhao ,  Alkan Gulses

Inventor： Stanley Huth ,  Denise Tran ,  Huawei Zhao ,  Alkan Gulses

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/00

CPC classification number: A61B3/1015 ,  A61B3/101 ,  A61B3/103 ,  A61B3/152 ,  A61F2009/00872

Abstract: Disclosed herein is a method of calculating tear film lipid and aqueous layer thicknesses and/or corneal surface refractive index from interferometry data obtained from simultaneous measurements of the aqueous and lipid layers of the tear film along with a measurement of the corneal surface reflectance.

Abstract translation: 本文公开了一种通过从泪膜的水性和脂质层的同时测量以及角膜表面反射率的测量获得的干涉测量数据计算泪膜脂质和水层厚度和/或角膜表面折射率的方法。

公开(公告)号：US08335476B2

公开(公告)日：2012-12-18

申请号：US12497809

申请日：2009-07-06

Applicant: Erdogan Alkan

Inventor： Erdogan Alkan

IPC: H04B17/00

CPC classification number: H04B17/10 ,  H04W88/085

Abstract: A maintenance method and system is provided. The method includes providing a device comprising a thru state switch and condition circuits. The device is permanently connected between a feed system and an antenna. The device receives a first control signal and disables a connection between the analyzer and the antenna. The device receives additional control signals and enables conditions. The device generates altered responses of the feed system. The altered responses are associated with the conditions. The altered responses are used to normalize an analyzer and the feed system or troubleshoot a communication system.

Abstract translation: 提供维护方法和系统。 该方法包括提供包括通状态开关和状态电路的装置。 设备永久连接在进料系统和天线之间。 设备接收第一控制信号，并禁用分析仪与天线之间的连接。 设备接收附加控制信号并启用条件。 设备会产生更改的进纸系统响应。 改变的反应与条件相关。 改变的响应用于标准化分析仪和进纸系统或排除通信系统故障。

公开(公告)号：US20120054819A1

公开(公告)日：2012-03-01

申请号：US13180100

申请日：2011-07-11

Applicant: Erdogan Alkan ,  Steven K. Shafer

Inventor： Erdogan Alkan ,  Steven K. Shafer

IPC: H04N7/16

CPC classification number: H04L12/2801 ,  H04L12/2838

Abstract: An in-home entertainment network conditioning device for use with a coaxial device in a CATV network includes an input node adapted to conduct CATV signals in a first and second frequency range, and in-home entertainment signals in a third frequency range that is different from the first frequency range and the second frequency range. The device includes a first signal path branched from the input node that includes a low-pass filter adapted to conduct the CATV signals and reject the in-home entertainment signals. A second signal path in parallel electrical communication with the first signal path includes a high-pass filter in series electrical connection with a signal conditioning circuit. The high-pass filter is adapted to conduct the in-home entertainment signals and reject the CATV signals. The signal conditioning circuit attenuates and equalizes the in-home entertainment signals when coupled to the coaxial device.

Abstract translation: 与CATV网络中的同轴设备一起使用的家庭娱乐网络调节装置包括适于在第一和第二频率范围内传送CATV信号的输入节点以及与第三频率范围不同的第三频率范围内的家庭娱乐信号 第一频率范围和第二频率范围。 该装置包括从输入节点分支的第一信号路径，其包括适于传导CATV信号并拒绝家庭内娱乐信号的低通滤波器。 与第一信号路径并联电连通的第二信号路径包括与信号调节电路串联电连接的高通滤波器。 高通滤波器适于进行家庭娱乐信号并拒绝CATV信号。 当耦合到同轴设备时，信号调理电路衰减并均衡家庭娱乐信号。

公开(公告)号：US20120015611A1

公开(公告)日：2012-01-19

申请号：US12837101

申请日：2010-07-15

Applicant: Erdogan Alkan

Inventor： Erdogan Alkan

IPC: H04B1/44

CPC classification number: H04B7/04 ,  H04B1/0475 ,  H04B1/525

Abstract: Embodiments of an apparatus for minimizing oscillation of an amplifier in an antenna system are provided. These embodiments can comprise passive circuitry in the form of a coupling simulator that includes passive elements selected and combined to generate an output with properties that can cancel or substantially reduce a coupled input as between two antennas in the antenna system. In one example, the coupling simulator may include a phase-shifting device and an attenuating device, each of which have properties with values selected based on parameters that result from the relationship between the antennas of the antenna system.

Abstract translation: 提供了一种用于最小化天线系统中的放大器的振荡的装置的实施例。 这些实施例可以包括耦合模拟器形式的无源电路，其包括被选择和组合的无源元件，以产生具有能够抵消或基本上减少天线系统中的两个天线之间的耦合输入的特性的输出。 在一个示例中，耦合模拟器可以包括相移装置和衰减装置，每个装置具有根据由天线系统的天线之间的关系产生的参数选择的值的属性。

公开(公告)号：US20110075311A1

公开(公告)日：2011-03-31

申请号：US12567086

申请日：2009-09-25

Applicant: Erdogan Alkan

Inventor： Erdogan Alkan

IPC: H02H3/22

CPC classification number: H01Q1/50

Abstract: A surge protector comprises an internal circuitry configured to isolate a premise device from a surge input. In one embodiment, the internal circuitry can comprise a first signal path and a second signal path that is inductively coupled to the first signal path. Each of the first signal path and the second signal path can comprise windings, such as the windings that are found in an RF transformer. The internal circuitry can also comprise a blocking element, which is coupled to the second signal path so that the blocking element receives the surge input before the premise device.

Abstract translation: 浪涌保护器包括内部电路，其被配置为将外部设备与浪涌输入隔离。 在一个实施例中，内部电路可以包括电感耦合到第一信号路径的第一信号路径和第二信号路径。 第一信号路径和第二信号路径中的每一个可以包括诸如在RF变压器中找到的绕组的绕组。 内部电路还可以包括阻塞元件，其耦合到第二信号路径，使得阻​​塞元件在前提器件之前接收浪涌输入。

公开(公告)号：US20110003558A1

公开(公告)日：2011-01-06

申请号：US12497809

申请日：2009-07-06

Applicant: Erdogan Alkan

Inventor： Erdogan Alkan

IPC: H04B17/00

CPC classification number: H04B17/10 ,  H04W88/085

Abstract: A maintenance method and system is provided. The method includes providing a device comprising a thru state switch and condition circuits. The device is permanently connected between a feed system and an antenna. The device receives a first control signal and disables a connection between the analyzer and the antenna. The device receives additional control signals and enables conditions. The device generates altered responses of the feed system. The altered responses are associated with the conditions. The altered responses are used to normalize an analyzer and the feed system or troubleshoot a communication system.

Abstract translation: 提供维护方法和系统。 该方法包括提供包括通状态开关和状态电路的装置。 设备永久连接在进料系统和天线之间。 设备接收第一控制信号，并禁用分析仪与天线之间的连接。 设备接收附加控制信号并启用条件。 设备会产生更改的进纸系统响应。 改变的反应与条件相关。 改变的响应用于标准化分析仪和进纸系统或排除通信系统故障。

公开(公告)号：US06720087B2

公开(公告)日：2004-04-13

申请号：US10193278

申请日：2002-07-12

Applicant: Reinhard Fried ,  Alkan Goecmen ,  Abdus S. Khan

Inventor： Reinhard Fried ,  Alkan Goecmen ,  Abdus S. Khan

IPC: B32B1504

CPC classification number: C23C28/3215 ,  C23C4/02 ,  C23C28/3455 ,  C23C28/44 ,  Y02T50/67 ,  Y10T428/12451 ,  Y10T428/12486 ,  Y10T428/12493 ,  Y10T428/12611 ,  Y10T428/12931 ,  Y10T428/12937 ,  Y10T428/12944

Abstract: The invention describes a temperature-stable protective coating over a metallic substrate surface (1), which coating includes at least one layer of material (4) consisting of MCrAlY, where M represents at least one of the elements selected from the group of materials consisting of Fe, Co and Ni. The invention also describes a production process for this coating. The invention is distinguished by the fact that a multiplicity of local elevations, known as rivets (3), are provided distributed directly over the area of the substrate surface (1) or distributed indirectly over the area of the substrate surface, separated from the substrate surface (1) by means of at least one interlayer (2), which rivets are fixedly joined to the substrate surface (1) or the interlayer (2), that at least one layer of material (4) consisting of MCrAlY is deposited on the substrate surface (1) or interlayer (2) in such a manner that the layer of material (4) consisting of MCrAlY completely surrounds the rivets (3), completely fills regions which lie between adjacent rivets (3) and projects above the rivets (3).

Abstract translation: 本发明描述了在金属基材表面（1）上的温度稳定的保护涂层，该涂层包括由MCrAlY组成的至少一层材料（4），其中M表示选自以下的材料中的至少一种元素： 的Fe，Co和Ni。 本发明还描述了该涂层的生产方法。 本发明的区别在于，提供了多个局部立面，称为铆钉（3），直接分布在衬底表面（1）的区域上，或间接地分布在与衬底分离的衬底表面的区域上 表面（1）通过至少一个中间层（2），所述铆钉固定地接合到基底表面（1）或中间层（2），至少一层由MCrAlY组成的材料层（4）沉积在 衬底表面（1）或中间层（2），使得由MCrAlY组成的材料层（4）完全包围铆钉（3），完全填充位于相邻铆钉（3）之间并突出在铆钉上方的区域 （3）。

公开(公告)号：US5580559A

公开(公告)日：1996-12-03

申请号：US311848

申请日：1994-09-23

Applicant: Bhanu Rajput ,  Bhabatosh Chaudhuri ,  Fredericus A. M. Asselbergs ,  Bernd Meyhack ,  Jutta Heim ,  Jan van Oostrum ,  Sefik Alkan

Inventor： Bhanu Rajput ,  Bhabatosh Chaudhuri ,  Fredericus A. M. Asselbergs ,  Bernd Meyhack ,  Jutta Heim ,  Jan van Oostrum ,  Sefik Alkan

IPC: C07K14/735 ,  C12N9/72 ,  C12N15/67 ,  C12N15/85 ,  A61K38/49 ,  C12N9/48 ,  C12N9/64

CPC classification number: C12N9/6456 ,  C07K14/70535 ,  C12N15/67 ,  C12N15/85 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2800/108 ,  C12N2830/002 ,  C12N2830/702

Abstract: Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.

Abstract translation: 具有由至少两个对应于人t-PA和人u-PA的氨基酸同一性和数量与子序列的亚序列组成的氨基酸序列的新型单链杂交纤维蛋白溶酶原激活物及其突变体，其中至少一个N 糖基化位点被修饰，使得在这些位点不能发生糖基化显示出有价值的药理学性质。 混合型纤溶酶原激活物是通过重组DNA技术产生的。

公开(公告)号：US5242819A

公开(公告)日：1993-09-07

申请号：US808936

申请日：1991-12-13

Applicant: Bhanu Rajput ,  Bhabatosh Chaudhuri ,  Fredericus A. M. Asselbergs ,  Bernd Meyhack ,  Jutta Heim ,  Jan van Oostrum ,  Sefik Alkan

Inventor： Bhanu Rajput ,  Bhabatosh Chaudhuri ,  Fredericus A. M. Asselbergs ,  Bernd Meyhack ,  Jutta Heim ,  Jan van Oostrum ,  Sefik Alkan

IPC: C07K14/735 ,  C12N9/72 ,  C12N15/67 ,  C12N15/85

CPC classification number: C12N9/6456 ,  C07K14/70535 ,  C12N15/67 ,  C12N15/85 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2800/108 ,  C12N2830/002 ,  C12N2830/702

Abstract: Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.

Abstract translation: 具有由至少两个对应于人t-PA和人u-PA的氨基酸同一性和数量与子序列的亚序列组成的氨基酸序列的新型单链杂交纤维蛋白溶酶原激活物及其突变体，其中至少一个N 糖基化位点被修饰，使得在这些位点不能发生糖基化显示出有价值的药理学性质。 混合型纤溶酶原激活物是通过重组DNA技术产生的。