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    Method and System for Treatment of a Body of a Mammal in Cardiac Arrest
    1.
    发明申请
    Method and System for Treatment of a Body of a Mammal in Cardiac Arrest 有权
    心脏骤停哺乳动物体内治疗方法及系统

    公开(公告)号：US20120226337A1

    公开(公告)日：2012-09-06

    申请号：US13039415

    申请日：2011-03-03

    申请人： Renaud Tissier ,  Alain Berdeaux

    发明人： Renaud Tissier ,  Alain Berdeaux

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61F2007/0063 ,  A61F2007/0069

    摘要： Method for treatment of a body of a mammal in cardiac arrest, comprising the step of performing a therapeutic hypothermia of the body after the cardiac arrest has occurred, said therapeutic hypothermia comprising: cooling the body to a target temperature during a cooling time period, said cooling being performed by total liquid ventilation which comprises alternately filling lungs of the body with a cooling liquid and removing from the lungs said cooling liquid, maintaining the body at the target temperature for a hypothermia duration.

    摘要翻译： 用于治疗心脏骤停的哺乳动物身体的方法，包括在心跳骤停发生后进行身体的治疗性体温低的步骤，所述治疗低温包括：在冷却期间将身体冷却至目标温度，所述 通过总液体通气进行冷却，其包括交替地用冷却液填充身体的肺，并从肺部除去所述冷却液，将身体保持在目标温度以进行低温持续时间。

    Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases
    3.
    发明授权
    Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases 失效
    有机硝酸盐，其制备方法及其在治疗心血管疾病中的应用

    公开(公告)号：US5591758A

    公开(公告)日：1997-01-07

    申请号：US971812

    申请日：1993-05-04

    申请人： Jean-Pierre Nallet ,  Jacques Dreux ,  Alain Berdeaux ,  Vincent Richard ,  Piero Martorana ,  Helmut Bohn

    发明人： Jean-Pierre Nallet ,  Jacques Dreux ,  Alain Berdeaux ,  Vincent Richard ,  Piero Martorana ,  Helmut Bohn

    IPC分类号： A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/54 ,  A61K38/00 ,  A61P9/08 ,  A61P9/10 ,  C07C323/23 ,  C07D213/62 ,  C07D277/06 ,  C07D279/04 ,  C07D493/04 ,  C07K9/00 ,  A01K31/425

    CPC分类号： C07D493/04 ,  C07D277/06 ,  C07K9/001 ,  A61K38/00

    摘要： Organic nitrates, processes for their preparation and their use in the treatment of vascular diseases and in particular in the treatment of angina.The said nitrates correspond to the following formula I:R--CO--(A).sub.n --Y--B (I)in which:R represents, in particular, a sulphur-containing radical and a sulphur-containing amino acid residue; A represents, in particular, a CH.sub.2 group or a substituted amino acid; n is 0 or 1 or greater than 1; Y represents an oxygen atom or an NH group and B represents, in particular, a 1,4:3,6-dianhydro hexitol mononitrate radical, an itol nitrate radical or an inositol radical.The said organic nitrates are prepared by reacting:I. either a thio acid of the type R--COOH, in which R has the same meaning as above, with a derivative of formula II: (A).sub.n --Y--B, in which A, Y, B and n have the same meaning as above,II. or a derivative of formula III: R--CO--(A).sub.n, in which R, A and n have the same meaning as above, with a derivative of formula Y--B, in which Y and B have the same meaning as above, in an appropriate solvent and under non-epimerising conditions.

    摘要翻译： PCT No.PCT / EP92 / 01746 Sec。 371日期：1993年5月4日 102（e）日期1993年5月4日PCT提交1992年8月1日PCT公布。 出版物WO93 / 03037 日期：1993年2月18日有机硝酸盐，其制备方法及其在治疗血管疾病中的用途，特别是治疗心绞痛。 所述硝酸盐对应于下式I：R-CO-（A）n -Y-B（I）其中：R表示特别是含硫基团和含硫氨基酸残基; A特别表示CH 2基团或取代的氨基酸; n为0或1或大于1; Y表示氧原子或NH基团，B表示特别是1,4：3,6-二脱水己糖醇单硝酸根基团，硝酸盐基团或肌醇基团。 所述有机硝酸盐通过以下方法制备：I。R-COOH型硫代酸，其中R具有与上述相同的含义，与式II的衍生物：（A）nYB反应，其中A，Y， B和n与上述相同，II。 或式III的衍生物：其中R，A和n具有与上述相同的含义，与式YB的衍生物（其中Y和B具有与上述相同的含义），R-CO-（A） 适当的溶剂和在非差向异构条件下。

    Method and system for treatment of a body of a mammal in cardiac arrest
    5.
    发明授权
    Method and system for treatment of a body of a mammal in cardiac arrest 有权
    用于治疗心脏骤停的哺乳动物身体的方法和系统

    公开(公告)号：US09439804B2

    公开(公告)日：2016-09-13

    申请号：US13039415

    申请日：2011-03-03

    申请人： Renaud Tissier ,  Alain Berdeaux

    发明人： Renaud Tissier ,  Alain Berdeaux

    IPC分类号： A61F7/12 ,  A61F7/00

    CPC分类号： A61F7/12 ,  A61F2007/0063 ,  A61F2007/0069

    摘要： Method for treatment of a body of a mammal in cardiac arrest, comprising the step of performing a therapeutic hypothermia of the body after the cardiac arrest has occurred, said therapeutic hypothermia comprising: cooling the body to a target temperature during a cooling time period, said cooling being performed by total liquid ventilation which comprises alternately filling lungs of the body with a cooling liquid and removing from the lungs said cooling liquid, maintaining the body at the target temperature for a hypothermia duration.