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公开(公告)号：US06569658B1
公开(公告)日：2003-05-27
申请号：US09645791
申请日：2000-08-24
Applicant: Ying Luo , C. Alan Fu , Mary Shen
Inventor： Ying Luo , C. Alan Fu , Mary Shen
IPC: C12N912
CPC classification number: C07K14/4738
Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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2.发明授权公开(公告)号：US06562591B1
公开(公告)日：2003-05-13
申请号：US09425324
申请日：1999-10-21
Applicant: Ying Luo , C. Alan Fu , Mary Shen
Inventor： Ying Luo , C. Alan Fu , Mary Shen
IPC: C12P2106
CPC classification number: C07K14/4738
Abstract: The present invention is directed to polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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公开(公告)号：US07122332B2
公开(公告)日：2006-10-17
申请号：US10039761
申请日：2001-10-19
Applicant: Brian Wong , Chong Alan Fu , Helena Mancebo , Xiulan X. Z. Zhou
Inventor： Brian Wong , Chong Alan Fu , Helena Mancebo , Xiulan X. Z. Zhou
CPC classification number: G01N33/9493 , G01N33/5047 , G01N33/505 , G01N33/5052
Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
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Patent Agency Ranking
公开(公告)号：US5803123A
公开(公告)日：1998-09-08
申请号：US510361
申请日：1995-08-02
Applicant: Joel David Bell , Alan Fu Chou
Inventor： Joel David Bell , Alan Fu Chou
CPC classification number: G01F1/40 , G01F1/34 , G01F15/18 , G01F15/185 , G01L19/0007 , G01L19/0015 , Y10T137/87249 , Y10T137/87885
Abstract: A mounting plate is disclosed that is adapted to be positioned between a main flow line and at least two differential pressure transmitters, to place the two differential pressure transmitters in fluid communication with a pair of pipeline taps on opposite sides of a flow reducing orifice plate in the main flow line is disclose. The mounting plate includes a plate-like body generally rectangular in cross section along its longitudinal axis and longer than it is wide along its transverse axis. The plate-like body includes a pair of ports that extend through the body and are in fluid communication with the pair of pressure taps with the longitudinal axis of the body parallel to the main flow line. A plurality of passageways or bores extend into the body to connect the ports to various combinations of pressure transmitters. One or more mounting holes for the transmitters are on a line that intersects the longitudinal axis of the body at an angle to allow some of the passageways or bores to be drilled straight and parallel to the longitudinal axis of the body between the mounting holes. In another embodiment, a sub plate is used to supply pressure to a third pressure transmitter. In another embodiment, a plate-like adapter, as well as the sub plate, is used to mount four differential transmitters or three differential pressure transmitters and a static pressure transmitter.
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公开(公告)号：US07045308B2
公开(公告)日：2006-05-16
申请号：US10112674
申请日：2002-03-29
Applicant: Brian Wong , Chong Alan Fu , Helena Mancebo , Xiulan X.Z. Zhou
Inventor： Brian Wong , Chong Alan Fu , Helena Mancebo , Xiulan X.Z. Zhou
CPC classification number: G01N33/9493 , G01N33/5047 , G01N33/505 , G01N33/5052
Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
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6.发明申请Modulators of lymphocyte activation, mkk3b compositions and methods of use 有权淋巴细胞活化调节剂，mkk3b组成和使用方法公开(公告)号：US20050170434A1
公开(公告)日：2005-08-04
申请号：US10495901
申请日：2002-11-18
Applicant: Alan Fu , Jun Wu , X. Liao , Helena Mancebo
Inventor： Alan Fu , Jun Wu , X. Liao , Helena Mancebo
CPC classification number: C12Q1/485 , A61K38/00 , A61K48/00 , C07K16/40 , C12N9/1205 , G01N33/5047 , G01N33/505 , G01N33/5052
Abstract: The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to lymphocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating lymphocyte activation.
Abstract translation: 本发明提供用于调节淋巴细胞活化的组合物和方法。 提供编码能够调节淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与淋巴细胞功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节淋巴细胞活化的生物活性剂的测定法。
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公开(公告)号：US5848607A
公开(公告)日：1998-12-15
申请号：US865925
申请日：1997-05-30
Applicant: Joel David Bell , Alan Fu Chou
Inventor： Joel David Bell , Alan Fu Chou
CPC classification number: G01F1/40 , G01F1/34 , G01F15/18 , G01F15/185 , G01L19/0007 , G01L19/0015 , Y10T137/87249 , Y10T137/87885
Abstract: A mounting plate is disclosed that is adapted to be positioned between a main flow line and at least two differential pressure transmitters, to place the two differential pressure transmitters in fluid communication with a pair of pipeline taps on opposite sides of a flow reducing orifice plate in the main flow line is disclose. The mounting plate includes a plate-like body generally rectangular in cross section along its longitudinal axis and longer than it is wide along its transverse axis. The plate-like body includes a pair of ports that extend through the body and are in fluid communication with the pair of pressure taps with the longitudinal axis of the body parallel to the main flow line. A plurality of passageways or bores extend into the body to connect the ports to various combinations of pressure transmitters. One or more mounting holes for the transmitters are on a line that intersects the longitudinal axis of the body at an angle to allow some of the passageways or bores to be drilled straight and parallel to the longitudinal axis of the body between the mounting holes.
Abstract translation: 公开了一种安装板，其适于定位在主流线和至少两个差压变送器之间，以将两个差压变送器放置在与减流孔板的相对侧上的一对管道龙头流体连通 主流线公开。 安装板包括沿着其纵向轴线的横截面大致矩形的板状体，并且沿着其横向轴线的宽度比其宽。 板状体包括一对延伸穿过主体并与主体的纵向轴线平行于主流线的一对压力分接头流体连通的端口。 多个通道或孔延伸到主体中，以将端口连接到压力变送器的各种组合。 用于发射器的一个或多个安装孔在与主体的纵向轴线成一定角度的线上，以允许一些通道或孔在安装孔之间直线钻孔并平行于主体的纵向轴线。
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8.发明授权公开(公告)号：US06562580B1
公开(公告)日：2003-05-13
申请号：US09645456
申请日：2000-08-24
Applicant: C. Alan Fu
Inventor： C. Alan Fu
IPC: G01N3353
CPC classification number: C07K14/4738
Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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