公开(公告)号：US07045308B2

公开(公告)日：2006-05-16

申请号：US10112674

申请日：2002-03-29

申请人： Brian Wong ,  Chong Alan Fu ,  Helena Mancebo ,  Xiulan X.Z. Zhou

发明人： Brian Wong ,  Chong Alan Fu ,  Helena Mancebo ,  Xiulan X.Z. Zhou

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/00 ,  G01N33/53

CPC分类号： G01N33/9493 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052

摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

公开(公告)号：US07122332B2

公开(公告)日：2006-10-17

申请号：US10039761

申请日：2001-10-19

申请人： Brian Wong ,  Chong Alan Fu ,  Helena Mancebo ,  Xiulan X. Z. Zhou

发明人： Brian Wong ,  Chong Alan Fu ,  Helena Mancebo ,  Xiulan X. Z. Zhou

IPC分类号： G01N33/53 ,  C12N15/63 ,  C12N15/00 ,  C12N15/12

CPC分类号： G01N33/9493 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052

摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

公开(公告)号：US20060199218A1

公开(公告)日：2006-09-07

申请号：US11431577

申请日：2006-05-09

申请人： Brian Wong ,  Chong Fu ,  Helena Mancebo ,  Xiulan Zhou

发明人： Brian Wong ,  Chong Fu ,  Helena Mancebo ,  Xiulan Zhou

IPC分类号： C12Q1/68 ,  G01N33/567 ,  G01N33/53

CPC分类号： G01N33/9493 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052

摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

公开(公告)号：US07368257B2

公开(公告)日：2008-05-06

申请号：US10495901

申请日：2002-11-18

申请人： Alan C. Fu ,  Jun Wu ,  X. Charlene Liao ,  Helena Mancebo

发明人： Alan C. Fu ,  Jun Wu ,  X. Charlene Liao ,  Helena Mancebo

IPC分类号： C12Q1/48 ,  C12Q1/02 ,  C12P21/06

CPC分类号： C12Q1/485 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12N9/1205 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052

摘要： The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to lymphocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating lymphocyte activation.

摘要翻译： 本发明提供用于调节淋巴细胞活化的组合物和方法。 提供编码能够调节淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与淋巴细胞功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节淋巴细胞活化的生物活性剂的测定法。

公开(公告)号：US06709839B1

公开(公告)日：2004-03-23

申请号：US09404967

申请日：1999-09-24

申请人： Ying Luo ,  Helena Mancebo

发明人： Ying Luo ,  Helena Mancebo

IPC分类号： C12N1512

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US20070196867A1

公开(公告)日：2007-08-23

申请号：US11529826

申请日：2006-09-29

申请人： Helena Mancebo ,  Jeng-Horng Her ,  Samuel Li ,  Jianfu Wang

发明人： Helena Mancebo ,  Jeng-Horng Her ,  Samuel Li ,  Jianfu Wang

IPC分类号： G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C07K14/705 ,  C07K16/28 ,  C12N15/86

CPC分类号： G01N33/68 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/6845 ,  G01N33/6851 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/52

摘要： The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines expressing GPCR proteins with the aid of the expression vectors of the instant invention. The recombinant cell lines of the instant invention express GPCR proteins at levels of at least about 150,000 copies of the protein per cell. The present invention also provides methods and compositions for raising antibodies against GPCR proteins using the high expressing recombinant cells of the instant invention.

摘要翻译： 本发明提供促进GPCR蛋白表达水平高的表达载体。 本发明所涵盖的是借助于本发明的表达载体表达GPCR蛋白的重组细胞系的方法和组合物。 本发明的重组细胞系以每个细胞至少约15万拷贝的蛋白质的量表达GPCR蛋白质。 本发明还提供使用本发明的高表达重组细胞提高针对GPCR蛋白的抗体的方法和组合物。

公开(公告)号：US07122630B1

公开(公告)日：2006-10-17

申请号：US10088960

申请日：2000-09-25

申请人： Ying Luo ,  Helena Mancebo

发明人： Ying Luo ,  Helena Mancebo

IPC分类号： C07K14/00 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US20050170434A1

公开(公告)日：2005-08-04

申请号：US10495901

申请日：2002-11-18

申请人： Alan Fu ,  Jun Wu ,  X. Liao ,  Helena Mancebo

发明人： Alan Fu ,  Jun Wu ,  X. Liao ,  Helena Mancebo

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12N9/12 ,  C12Q1/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567

CPC分类号： C12Q1/485 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12N9/1205 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052

摘要： The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to lymphocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating lymphocyte activation.

摘要翻译： 本发明提供用于调节淋巴细胞活化的组合物和方法。 提供编码能够调节淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与淋巴细胞功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节淋巴细胞活化的生物活性剂的测定法。