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    HEAT EXCHANGER PERFORATED FINS
    2.
    发明申请
    HEAT EXCHANGER PERFORATED FINS 审中-公开
    热交换器执行FINS

    公开(公告)号：US20130167584A1

    公开(公告)日：2013-07-04

    申请号：US13823147

    申请日：2010-09-29

    申请人： Swaminathan Sunder ,  Vladimir Yliy Gershtein ,  George Amir Meski ,  Patrick Alan Houghton

    发明人： Swaminathan Sunder ,  Vladimir Yliy Gershtein ,  George Amir Meski ,  Patrick Alan Houghton

    IPC分类号： F28F3/08 ,  F25J5/00 ,  B21D53/04 ,  F28F13/18 ,  B21D53/02

    CPC分类号： F28F3/08 ,  B21D53/022 ,  B21D53/04 ,  F25J5/00 ,  F25J5/002 ,  F25J2290/12 ,  F28D9/0062 ,  F28F3/027 ,  F28F13/18 ,  Y10T29/49366

    摘要： A plate fin heat exchanger comprises a folded fin sheet comprising fins wherein the fin sheet comprises a plurality of perforations, such plurality of perforations are positioned on the fin sheet in parallel rows when such fin sheet is in an unfolded state, such parallel rows of perforations on the fin sheet comprise a first spacing between the parallel rows of perforations (S1), a second spacing between sequential perforations within the parallel row of perforations (S2), a third spacing (or offset) between the perforations in adjacent parallel rows of perforations (S3), and a perforation diameter (D), wherein the ratio of the first spacing between the parallel rows of perforations to the perforation diameter (S1/D) is in the range of 0.75 to 2.0, and wherein the angle between the fins and the parallel rows of perforations is less than or equal to five degrees (≦5°).

    摘要翻译： 板翅式热交换器包括折叠翅片，其包括翅片，其中翅片包括多个穿孔，当这种翅片处于展开状态时，这些多个穿孔以平行排列在翅片上，这样平行的穿孔排 在翅片上包括平行的穿孔列（S1）之间的第一间隔，平行的穿孔列（S2）中的连续穿孔之间的第二间隔，邻近的平行排孔中的穿孔之间的第三间隔（或偏移） （S3）和穿孔直径（D），其中平行的穿孔排与穿孔直径（S1 / D）之间的第一间隔的比率在0.75至2.0的范围内，并且其中翅片之间的角度 平行的穿孔排小于或等于五度（@ 5°）。

    Method for treatment of cancer and infectious disease and compositions useful in same
    4.
    发明授权
    Method for treatment of cancer and infectious disease and compositions useful in same 失效
    用于治疗癌症和感染性疾病的方法和可用于其的组合物

    公开(公告)号：US06331299B1

    公开(公告)日：2001-12-18

    申请号：US09011648

    申请日：1998-02-13

    申请人： James E. Rothman ,  F. Ulrich Hartl ,  Mee H. Hoe ,  Alan Houghton ,  Yoshizumi Takeuchi ,  Mark Mayhew

    发明人： James E. Rothman ,  F. Ulrich Hartl ,  Mee H. Hoe ,  Alan Houghton ,  Yoshizumi Takeuchi ,  Mark Mayhew

    IPC分类号： A61K4800

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/0011 ,  A61K47/646 ,  A61K47/65 ,  A61K47/6901 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/6043 ,  A61K2039/622 ,  A61K2039/625 ,  C07K7/08 ,  C07K14/47

    摘要： Administration of expressible polynucleotides encoding eukaryotic heat shock proteins to mammalian cells leads to the stimulation of an immune response to antigens present in those cells. This makes it possible to stimulate an immune response to target antigens, including target tumor antigens or antigens associated with an infectious disease, without having to isolate a unique antigen or antigen-associated with an infectious disease, without having to isolate a unique antigen or antigen-associated heat shock protein for each target antigen by administering to a mammalian subject or to a group of mammalian cells containing the antigen, an expressible polynucleotide encoding a heat shock protein. The expressed heat shock protein may have the same structure as native heat shock proteins, or may have a modified form adapted to control the trafficking of the expressed heat shock protein within the cells.

    摘要翻译： 向哺乳动物细胞施用编码真核热休克蛋白的可表达多核苷酸导致对存在于这些细胞中的抗原的免疫应答的刺激。 这使得可以刺激针对靶抗原（包括靶肿瘤抗原或与感染性疾病相关的抗原）的免疫应答，而不必分离独特的抗原或与感染性疾病相关的抗原，而不必分离独特的抗原或抗原 通过向哺乳动物受试者或含有抗原的一组哺乳动物细胞施用与靶标抗原相关的热休克蛋白，即编码热休克蛋白的可表达多核苷酸。 表达的热休克蛋白可以具有与天然热休克蛋白相同的结构，或者可以具有适于控制细胞内表达的热休克蛋白的运输的修饰形式。

    SHIELDING IN A SEPARATION COLUMN
    6.
    发明申请
    SHIELDING IN A SEPARATION COLUMN 有权
    隔离柱中的屏蔽

    公开(公告)号：US20140013946A1

    公开(公告)日：2014-01-16

    申请号：US14007869

    申请日：2011-03-31

    申请人： Vladimir Yliy Gershtein ,  Patrick Alan Houghton ,  Kenneth William Kovak ,  Andrew Weaver ,  Jonathan Wilson

    发明人： Vladimir Yliy Gershtein ,  Patrick Alan Houghton ,  Kenneth William Kovak ,  Andrew Weaver ,  Jonathan Wilson

    IPC分类号： B01D53/18

    CPC分类号： B01D53/185 ,  B01D3/008 ,  F25J3/04909 ,  F25J3/04927 ,  F25J2290/20

    摘要： A liquid distributor and method for distribution of a liquid in a mass transfer column, the distributor includes at least one riser comprising at least one riser wall, the at least one riser wall extends from a first surface of the distributor in a first direction of the mass transfer column; at least one shield, the at least one shield extends from a second surface of the distributor opposite the first surface and extending in a second direction opposite the first direction; and at least one liquid distribution aperture extending from the first surface of the distributor through the second surface of the distributor, the at least one shield has a length extending in the second direction such that a gap is created between the at least one shield and a packing, the height of the gap between the shield and the packing is about 10 mm to 75 mm.

    摘要翻译： 一种用于在传质塔中分配液体的液体分配器和方法，所述分配器包括至少一个提升管，所述至少一个提升管包括至少一个提升管壁，所述至少一个提升管壁沿着所述分配器的第一方向从所述分配器的第一表面延伸 传质柱; 至少一个屏蔽件，所述至少一个屏蔽件从所述分配器的与所述第一表面相对的第二表面延伸并且沿与所述第一方向相反的第二方向延伸; 以及从分配器的第一表面延伸通过分配器的第二表面的至少一个液体分配孔，所述至少一个屏蔽件具有在第二方向上延伸的长度，使得在至少一个屏蔽件和 包装时，屏蔽和包装之间的间隙高度约为10 mm至75 mm。