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公开(公告)号:US06875607B1
公开(公告)日:2005-04-05
申请号:US09436164
申请日:1999-11-09
申请人: Benjamin Eithan Reubinoff , Martin Frederick Pera , Chui-Yee Fong , Alan Osborne Trounson , Ariffeen Bongso
发明人: Benjamin Eithan Reubinoff , Martin Frederick Pera , Chui-Yee Fong , Alan Osborne Trounson , Ariffeen Bongso
IPC分类号: C12N15/09 , A61K35/12 , C12N5/02 , C12N5/0735 , C12N5/077 , C12N5/10 , C12R1/91 , A01N1/00 , C12N5/00
CPC分类号: C12N5/0652 , A61K35/12 , C12N5/0606 , C12N2502/13 , C12N2506/02
摘要: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation, production of differentiated cells and in particular the production of human embryonic stem cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells capable of giving rise to mature somatic cells and uses thereof. The present invention also provides a purified preparation of undifferentiated human embryonic stem cells capable of proliferation in vitro. Furthermore, the present invention provides a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell. There is also provided a committed progenitor cell capable of giving rise to mature somatic cells.
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公开(公告)号:US20100266552A1
公开(公告)日:2010-10-21
申请号:US12601570
申请日:2008-05-28
申请人: Graham Jenkin , Alan Osborne Trounson , Euan Morrison Wallace , Yuben Moodley , Ursula Manuelpillai , Sivakami Ilancheran
发明人: Graham Jenkin , Alan Osborne Trounson , Euan Morrison Wallace , Yuben Moodley , Ursula Manuelpillai , Sivakami Ilancheran
CPC分类号: A61K35/48 , A61K31/01 , A61K35/50 , C12N5/0605
摘要: A method of cellular therapy for a lung disease or condition in a subject is disclosed, wherein the method involves the administration of multipotent epithelial stem cells derived from amnion tissue (AECs). In a particular application, the method is used for the treatment of lung diseases and conditions such as chronic lung diseases including chronic obstructive pulmonary disease (COPD), acute lung conditions such as acute respiratory distress syndrome (ARDS), and ventilator associated lung injury (VALI).
摘要翻译: 公开了一种针对受试者的肺部疾病或病症的细胞疗法的方法,其中所述方法涉及来自羊膜组织(AEC)的多能上皮干细胞的施用。 在特定应用中,该方法用于治疗肺部疾病和病症,例如慢性肺疾病,包括慢性阻塞性肺病(COPD),急性肺部疾病如急性呼吸窘迫综合征(ARDS)和呼吸机相关性肺损伤 VALI)。
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