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公开(公告)号：US06875607B1
公开(公告)日：2005-04-05
申请号：US09436164
申请日：1999-11-09
申请人： Benjamin Eithan Reubinoff , Martin Frederick Pera , Chui-Yee Fong , Alan Osborne Trounson , Ariffeen Bongso
发明人： Benjamin Eithan Reubinoff , Martin Frederick Pera , Chui-Yee Fong , Alan Osborne Trounson , Ariffeen Bongso
IPC分类号： C12N15/09 , A61K35/12 , C12N5/02 , C12N5/0735 , C12N5/077 , C12N5/10 , C12R1/91 , A01N1/00 , C12N5/00
CPC分类号： C12N5/0652 , A61K35/12 , C12N5/0606 , C12N2502/13 , C12N2506/02
摘要： The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation, production of differentiated cells and in particular the production of human embryonic stem cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells capable of giving rise to mature somatic cells and uses thereof. The present invention also provides a purified preparation of undifferentiated human embryonic stem cells capable of proliferation in vitro. Furthermore, the present invention provides a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell. There is also provided a committed progenitor cell capable of giving rise to mature somatic cells.
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公开(公告)号：US08137969B2
公开(公告)日：2012-03-20
申请号：US12157864
申请日：2008-06-13
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0606 , C12N5/0619 , C12N5/0622 , C12N2500/32 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof.
摘要翻译： 本发明涉及未分化的人类胚胎干细胞，培养和繁殖方法以及分化细胞的产生。 特别地，它涉及能够在体外产生体细胞分化细胞的人ES细胞的产生，以及确定的祖细胞，例如能够产生包括神经细胞和/或胶质细胞的成熟体细胞的神经祖细胞及其用途 。
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3.发明授权公开(公告)号：US07011828B2
公开(公告)日：2006-03-14
申请号：US09970543
申请日：2001-10-04
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0606 , C12N5/0619 , C12N5/0622 , C12N2500/32 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/395 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof.This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
摘要翻译： 本发明涉及未分化的人类胚胎干细胞，培养和繁殖方法以及分化细胞的产生。 特别地，它涉及能够在体外产生体细胞分化细胞的人ES细胞的产生，以及确定的祖细胞，例如能够产生包括神经细胞和/或胶质细胞的成熟体细胞的神经祖细胞及其用途 。 本发明提供了产生ES细胞向神经谱系的受控分化的体外和体内模型的方法。 沿着神经分化途径产生的模型和细胞可用于：人类神经发育的细胞和分子生物学的研究，发现基因，生长因子和在神经分化中发挥作用的分化因子， 再生，药物发现和开发用于致畸，毒性和神经保护作用的筛选试验。
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公开(公告)号：US20090075373A1
公开(公告)日：2009-03-19
申请号：US12157864
申请日：2008-06-13
IPC分类号： C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0606 , C12N5/0619 , C12N5/0622 , C12N2500/32 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof.This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
摘要翻译： 本发明涉及未分化的人类胚胎干细胞，培养和繁殖方法以及分化细胞的产生。 特别地，它涉及能够在体外产生体细胞分化细胞的人ES细胞的产生，以及确定的祖细胞，例如能够产生包括神经细胞和/或胶质细胞的成熟体细胞的神经祖细胞及其用途 。 本发明提供了产生ES细胞向神经谱系的受控分化的体外和体内模型的方法。 沿着神经分化途径产生的模型和细胞可用于：人类神经发育的细胞和分子生物学的研究，发现基因，生长因子和在神经分化中发挥作用的分化因子， 再生，药物发现和开发用于致畸，毒性和神经保护作用的筛选试验。
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公开(公告)号：US07947498B2
公开(公告)日：2011-05-24
申请号：US12367075
申请日：2009-02-06
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0606 , C12N5/0619 , C12N5/0622 , C12N2500/32 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
摘要翻译： 本发明提供未分化的人胚胎干细胞，培养和繁殖方法以及分化细胞的产生。 特别涉及能够在体外产生体细胞分化细胞的人类ES细胞的产生，以及定向的祖细胞，例如能够产生包括神经细胞和/或胶质细胞的成熟体细胞的神经祖细胞及其用途。 本发明还提供了产生ES细胞向神经谱系的受控分化的体外和体内模型的方法。 该模型和沿着神经分化途径产生的细胞可用于研究人神经发育的细胞和分子生物学，用于发现在神经中发挥作用的基因，生长因子和分化因子 分化和再生，用于药物发现和开发用于致畸，毒性和神经保护作用的筛选测定。
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公开(公告)号：US07504257B2
公开(公告)日：2009-03-17
申请号：US09808382
申请日：2001-03-14
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0606 , C12N5/0619 , C12N5/0622 , C12N2500/32 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
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7.发明授权Generation of neural stem cells from undifferentiated human embryonic stem cells 有权从未分化的人胚胎干细胞产生神经干细胞公开(公告)号：US08133730B2
公开(公告)日：2012-03-13
申请号：US12134521
申请日：2008-06-06
CPC分类号： C12N5/0619 , A61K35/12 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/155 , C12N2506/02
摘要： The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
摘要翻译： 本发明涉及从未分化的人胚胎干细胞产生神经细胞。 特别地，其涉及将人ES细胞分化为神经祖细胞和神经细胞以及特定类型的功能性神经细胞和/或神经细胞的产生。 本发明还包括使用这些细胞用于治疗诸如帕金森病的神经病症。
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公开(公告)号：US08460931B2
公开(公告)日：2013-06-11
申请号：US13361976
申请日：2012-01-31
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0606 , C12N5/0619 , C12N5/0622 , C12N2500/32 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
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9.发明申请公开(公告)号：US20090004736A1
公开(公告)日：2009-01-01
申请号：US12134521
申请日：2008-06-06
IPC分类号： C12N5/06
CPC分类号： C12N5/0619 , A61K35/12 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/155 , C12N2506/02
摘要： The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
摘要翻译： 本发明涉及从未分化的人胚胎干细胞产生神经细胞。 特别地，其涉及将人ES细胞分化为神经祖细胞和神经细胞以及特定类型的功能性神经细胞和/或神经细胞的产生。 本发明还包括使用这些细胞用于治疗诸如帕金森病的神经病症。
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公开(公告)号：US09650605B2
公开(公告)日：2017-05-16
申请号：US13360826
申请日：2012-01-30
IPC分类号： C12N5/079 , C12N5/0793 , C12N5/22 , C12N5/095 , A61K35/12
CPC分类号： C12N5/0619 , A61K35/12 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/155 , C12N2506/02
摘要： The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
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