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公开(公告)号：US08193334B2
公开(公告)日：2012-06-05
申请号：US12573411
申请日：2009-10-05
CPC分类号： A61K9/5153 , A61K9/1075 , A61K9/5123 , A61K47/6907
摘要： A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.
摘要翻译： 公开了将核酸特别是siRNA，shRNA，微RNA，基因治疗质粒和其它寡核苷酸包封在可生物降解的聚合物中的方法，由此将核酸配制成由无毒和/或天然存在的脂质组成的反胶束， 通过纳米沉淀法形成纳米颗粒。 该方法可以与改善细胞内药物靶向的其它技术相结合，最终增强前述核酸的细胞内递送。
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公开(公告)号：US20100196482A1
公开(公告)日：2010-08-05
申请号：US12573411
申请日：2009-10-05
IPC分类号： A61K9/00 , A61K31/711 , A61K31/7105 , A61P43/00
CPC分类号： A61K9/5153 , A61K9/1075 , A61K9/5123 , A61K47/6907
摘要： A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.
摘要翻译： 公开了将核酸特别是siRNA，shRNA，微RNA，基因治疗质粒和其它寡核苷酸包封在可生物降解的聚合物中的方法，由此将核酸配制成由无毒和/或天然存在的脂质组成的反胶束， 通过纳米沉淀法形成纳米颗粒。 该方法可以与改善细胞内药物靶向的其它技术相结合，最终增强前述核酸的细胞内递送。
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公开(公告)号：US20090074828A1
公开(公告)日：2009-03-19
申请号：US12098354
申请日：2008-04-04
申请人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
发明人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K47/42 , A61K31/135 , A61K31/337 , A61K38/16 , A61K31/4353 , A61K31/56 , A61K9/00 , C07K5/10 , A61P9/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译： 本发明一般涉及聚合物和大分子，特别是涉及可用于颗粒如纳米颗粒的聚合物。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 本发明的其它方面涉及使用纳米颗粒文库的方法。
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公开(公告)号：US20100203142A1
公开(公告)日：2010-08-12
申请号：US12573591
申请日：2009-10-05
申请人： Liangfang ZHANG , Aleksandar F. RADOVIC-MORENO , Frank X. GU , Frank ALEXIS , Robert S. LANGER , Omid C. FAROKHZAD
发明人： Liangfang ZHANG , Aleksandar F. RADOVIC-MORENO , Frank X. GU , Frank ALEXIS , Robert S. LANGER , Omid C. FAROKHZAD
IPC分类号： A61K9/14 , A61K38/19 , A61K39/00 , A61K38/02 , A61K31/7088 , A61K31/565 , A61K31/337 , A61P9/10 , A61P35/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译： 本发明通常涉及具有两亲性组分的纳米颗粒。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 本发明的其它方面涉及使用纳米颗粒文库的方法。
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公开(公告)号：US09333179B2
公开(公告)日：2016-05-10
申请号：US12573591
申请日：2009-10-05
申请人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
发明人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译： 本发明通常涉及具有两亲性组分的纳米颗粒。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 本发明的其它方面涉及使用纳米颗粒文库的方法。
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