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公开(公告)号：US20090074828A1
公开(公告)日：2009-03-19
申请号：US12098354
申请日：2008-04-04
申请人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
发明人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K47/42 , A61K31/135 , A61K31/337 , A61K38/16 , A61K31/4353 , A61K31/56 , A61K9/00 , C07K5/10 , A61P9/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译： 本发明一般涉及聚合物和大分子，特别是涉及可用于颗粒如纳米颗粒的聚合物。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 本发明的其它方面涉及使用纳米颗粒文库的方法。
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公开(公告)号：US09333179B2
公开(公告)日：2016-05-10
申请号：US12573591
申请日：2009-10-05
申请人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
发明人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译： 本发明通常涉及具有两亲性组分的纳米颗粒。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 本发明的其它方面涉及使用纳米颗粒文库的方法。
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公开(公告)号：US20100233251A1
公开(公告)日：2010-09-16
申请号：US12681814
申请日：2008-10-12
申请人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
发明人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。
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公开(公告)号：US08193334B2
公开(公告)日：2012-06-05
申请号：US12573411
申请日：2009-10-05
CPC分类号： A61K9/5153 , A61K9/1075 , A61K9/5123 , A61K47/6907
摘要： A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.
摘要翻译： 公开了将核酸特别是siRNA，shRNA，微RNA，基因治疗质粒和其它寡核苷酸包封在可生物降解的聚合物中的方法，由此将核酸配制成由无毒和/或天然存在的脂质组成的反胶束， 通过纳米沉淀法形成纳米颗粒。 该方法可以与改善细胞内药物靶向的其它技术相结合，最终增强前述核酸的细胞内递送。
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公开(公告)号：US10736848B2
公开(公告)日：2020-08-11
申请号：US12681814
申请日：2008-10-12
申请人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
发明人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US20110052697A1
公开(公告)日：2011-03-03
申请号：US12301225
申请日：2007-05-17
申请人： Omid C. Farokhzad , Sangyong Jon , Vaishali Bagalkot , Liangfang Zhang , Benjamin Teply , Etgar Levy-Nissenbaum , Robert S. Langer
发明人： Omid C. Farokhzad , Sangyong Jon , Vaishali Bagalkot , Liangfang Zhang , Benjamin Teply , Etgar Levy-Nissenbaum , Robert S. Langer
IPC分类号： A61K9/14 , C07H21/04 , A61K31/7088 , A61P35/00
CPC分类号： A61K31/704 , A61K31/337 , A61K47/549 , A61K47/6935 , A61K47/6937 , A61K48/00 , A61K49/0019 , A61K49/0021 , A61K49/0054 , A61K49/0067 , B82Y5/00
摘要： The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.
摘要翻译： 本发明提供用于靶向递送治疗剂器官，组织，细胞，细胞外基质组分和细胞内区室的系统，方法和组合物。 本发明提供了包含治疗剂或诊断剂和核酸靶向部分的复合物，其中所述药剂与核酸靶向部分的碱基对非共价缔合。 本发明提供了包含颗粒和本发明复合物的目标颗粒。 本发明提供了设计，制造和使用本发明复合物和靶向颗粒的方法。
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公开(公告)号：US20110027172A1
公开(公告)日：2011-02-03
申请号：US12747040
申请日：2008-12-10
申请人： Zhuang Wang , Omid C. Farokhzad , Liangfang Zhang , Aleksandar Filip Radovic-Moreno , Frank X. Gu , Robert S. Langer
发明人： Zhuang Wang , Omid C. Farokhzad , Liangfang Zhang , Aleksandar Filip Radovic-Moreno , Frank X. Gu , Robert S. Langer
CPC分类号： A61K51/1255 , A61K31/337 , A61K47/6937
摘要： The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.
摘要翻译： 本发明提供了用于递送药剂和放射性药剂的药物递送系统。 药物递送系统可以特异性地靶向器官，组织，细胞，细胞外基质或细胞内区室。 通常，药物递送系统是颗粒。 还提供了包含本发明颗粒的药物组合物。 本发明提供了制备和使用本发明的颗粒和药物组合物的方法。 本发明的颗粒可用于治疗和诊断各种疾病，包括癌症。 本发明的颗粒也可用于在体内追踪颗粒。
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公开(公告)号：US20120156135A1
公开(公告)日：2012-06-21
申请号：US13122654
申请日：2009-10-06
申请人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
发明人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
CPC分类号： A61K47/48915 , A61K8/14 , A61K8/86 , A61K31/7088 , A61K39/0005 , A61K39/39 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K49/0065 , A61K49/0067 , A61K49/0093 , A61K2039/55516 , A61K2039/55555 , A61K2039/6093 , A61Q19/00 , B82Y5/00 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/32
摘要： This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
摘要翻译： 本公开涉及以受控马赛克图案显示多个功能化表面结构域的颗粒（例如，纳米颗粒和微粒）。 本公开还提供了简单的方法来产生具有多个功能化表面域的各种颗粒，同时允许使用各种不同的核心结构。 多个功能化区域提供可控的颗粒结合和取向，以及受控和持续的药物释放特征。
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公开(公告)号：US09333163B2
公开(公告)日：2016-05-10
申请号：US13122654
申请日：2009-10-06
申请人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
发明人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
CPC分类号： A61K47/48915 , A61K8/14 , A61K8/86 , A61K31/7088 , A61K39/0005 , A61K39/39 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K49/0065 , A61K49/0067 , A61K49/0093 , A61K2039/55516 , A61K2039/55555 , A61K2039/6093 , A61Q19/00 , B82Y5/00 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/32
摘要： This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
摘要翻译： 本公开涉及以受控马赛克图案显示多个功能化表面结构域的颗粒（例如，纳米颗粒和微粒）。 本公开还提供了简单的方法来产生具有多个功能化表面域的各种颗粒，同时允许使用各种不同的核心结构。 多个功能化区域提供可控的颗粒结合和取向，以及受控和持续的药物释放特征。
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公开(公告)号：US20130028962A1
公开(公告)日：2013-01-31
申请号：US13607094
申请日：2012-09-07
IPC分类号： A61K9/127 , A61K31/327 , A61K38/14 , A61P31/00 , A61P35/00 , A61P17/00 , A61K31/20 , A61P31/04 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/5115 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/1271
摘要： Control of the fusion activity of liposomes by adsorbing biocompatible nanoparticles to the outer surface of phospholipid liposomes is disclosed. The biocompatible nanoparticles effectively prevent liposomes from fusing with one another. Release of cargo from the liposome is accomplished via trigger mechanisms that include pH triggers, pore forming toxing triggers and photosensitive triggers. Dermal drug delivery to treat a variety of skin diseases such as acne vulgaris and staph infections is contemplated.
摘要翻译： 公开了通过将生物相容纳米颗粒吸附到磷脂脂质体的外表面来控制脂质体的融合活性。 生物相容纳米颗粒有效地防止脂质体彼此融合。 货物从脂质体的释放是通过触发机制实现的，这些机制包括pH触发，成孔毒素触发和光敏触发。 预期用于治疗各种皮肤疾病如寻常痤疮和葡萄球菌感染的皮肤药物递送。
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