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    Tumor suppressor designated TS10q23.3
    1.
    发明申请
    Tumor suppressor designated TS10q23.3 有权
    肿瘤抑制因子指定为TS10q23.3

    公开(公告)号：US20050147995A1

    公开(公告)日：2005-07-07

    申请号：US10979642

    申请日：2004-11-01

    申请人： Peter Steck ,  Mark Pershouse ,  Samar Jasser ,  Alfred Yung ,  Sean Tavtigian

    发明人： Peter Steck ,  Mark Pershouse ,  Samar Jasser ,  Alfred Yung ,  Sean Tavtigian

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N9/16 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/57496 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12N9/16 ,  C12N2799/021 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/16 ,  C12Q2600/172 ,  G01N33/57407 ,  G01N33/57434 ,  G01N2333/916

    摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

    摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。

    Tumor suppressor designated TS10Q23.3
    6.
    发明申请
    Tumor suppressor designated TS10Q23.3 有权
    肿瘤抑制因子指定为TS10Q23.3

    公开(公告)号：US20070054333A1

    公开(公告)日：2007-03-08

    申请号：US11590556

    申请日：2006-10-30

    申请人： Peter Steck ,  Mark Pershouse ,  Samar Jasser ,  Alfred Yung ,  Sean Tavtigian

    发明人： Peter Steck ,  Mark Pershouse ,  Samar Jasser ,  Alfred Yung ,  Sean Tavtigian

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57496 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12N9/16 ,  C12N2799/021 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/16 ,  C12Q2600/172 ,  G01N33/57407 ,  G01N33/57434 ,  G01N2333/916

    摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

    摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。

    Tumor suppressor designated TS10Q23.3
    7.
    发明授权
    Tumor suppressor designated TS10Q23.3 失效
    肿瘤抑制因子指定为TS10Q23.3

    公开(公告)号：US06262242B1

    公开(公告)日：2001-07-17

    申请号：US08791115

    申请日：1997-01-30

    申请人： Peter Steck ,  Mark A. Pershouse ,  Samar A. Jasser ,  W. K. Alfred Yung ,  Sean V. Tavtigian

    发明人： Peter Steck ,  Mark A. Pershouse ,  Samar A. Jasser ,  W. K. Alfred Yung ,  Sean V. Tavtigian

    IPC分类号： C07H204

    CPC分类号： C12N9/16 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12N2799/021

    摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

    摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。