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公开(公告)号:US20100113607A1
公开(公告)日:2010-05-06
申请号:US12635793
申请日:2009-12-11
IPC分类号: A61K31/135 , A61K31/4178 , A61K31/4164 , A61K31/496 , A61K31/4196 , A61P31/10
CPC分类号: A61K41/0042 , A61K41/00 , A61K41/0019 , A61K31/495 , A61K31/415 , A61K31/41 , A61K31/135 , A61K2300/00
摘要: A method for the topical treatment of nail diseases, e.g. onychomycosis, after preparation of the infected nail with a laser beam.
摘要翻译: 用于局部治疗指甲疾病的方法,例如, 在用激光束制备感染的指甲后,甲真菌病。
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公开(公告)号:US06437345B1
公开(公告)日:2002-08-20
申请号:US09711294
申请日:2000-11-14
申请人: Alfredo Emilio Bruno-Raimondi , Reinhard Völkel , Gert Ludwig Duveneck , Carlo Stefan Effenhauser , Hans-Peter Herzig , René Dändliker
发明人: Alfredo Emilio Bruno-Raimondi , Reinhard Völkel , Gert Ludwig Duveneck , Carlo Stefan Effenhauser , Hans-Peter Herzig , René Dändliker
IPC分类号: G01N2164
CPC分类号: G01N27/44782 , G01N21/474 , G01N27/44721 , G01N27/44791
摘要: An optical sensing unit is provided which comprises at least one sample measurement cell, at least one excitation light source acting upon the or each measurement cell to provide one or more sensor fields defining an array of measurement fields, a photoelectric detector array for detecting the intensity of light emitted from the or each measurement cell in response to excitation light, and means for directing light emitted from each measurement field to a respective portion of the photoelectric detector array. The sensing unit may be used in combination with multiplexed waveguide arrays or multiplexed planar cappillary chromatography or electrophoresis chips.
摘要翻译: 提供了一种光学感测单元,其包括至少一个采样测量单元,至少一个作用在所述测量单元或每个测量单元上的激发光源,以提供限定测量场阵列的一个或多个传感器场;用于检测强度的光电检测器阵列 响应于激发光从所述测量单元或每个测量单元发射的光;以及用于将从每个测量场发射的光引导到光电检测器阵列的相应部分的装置。 感测单元可以与多路波导阵列或多路平面毛细管色谱或电泳芯片组合使用。
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公开(公告)号:US06384912B1
公开(公告)日:2002-05-07
申请号:US09742391
申请日:2000-12-22
申请人: Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
发明人: Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
IPC分类号: G01N110
摘要: A device has a planar optical waveguide, including a transparent carrier (40) and a wave-guiding layer (41), wherein the waveguide at least has a diffractive element (42) for coupling excitation radiation into the wave-guiding layer. Located on the wave-guiding layer is a further, tightly sealing layer (43) made from a material which, at least at the support surface, is transparent both to the excitation radiation and to the evanescently excited radiation at least to the penetration depth of the evanescent field, and which, for an analysis sample, has, at least in a partial region of the guided excitation radiation, a cavity (45) which is open to the upper side or a cavity (6) which is closed to the upper side and connected by means of an inlet channel (2) and an outlet channel (3). The depth of the cavity corresponds at least to the penetration depth of the evanescent field, and the diffractive element (42) is fully covered by the material of the layer (43) at least in the coupling-in region of the excitation radiation.
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公开(公告)号:US20110238003A1
公开(公告)日:2011-09-29
申请号:US13097896
申请日:2011-04-29
IPC分类号: A61M35/00
CPC分类号: A61K9/70 , A61B18/203 , A61B2017/00765 , A61B2018/00452
摘要: A method for systemically delivering a pharmaceutical composition to a human or animal, said method comprising forming an orifice in a nail of a human or animal by means of a laser-based device and applying a pharmaceutical composition in the orifice, wherein said method provides a controlled release of the pharmaceutical composition.
摘要翻译: 一种用于将药物组合物全身递送至人或动物的方法,所述方法包括通过基于激光的装置在人或动物的指甲中形成孔口,并将药物组合物施用于孔中,其中所述方法提供 控释药物组合物。
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公开(公告)号:US20110082448A1
公开(公告)日:2011-04-07
申请号:US12893295
申请日:2010-09-29
IPC分类号: A61B18/20
CPC分类号: A61K41/0042 , A61K41/00 , A61K41/0019 , A61K31/495 , A61K31/415 , A61K31/41 , A61K31/135 , A61K2300/00
摘要: A method for the topical treatment of nail diseases, e.g. onychomycosis, after preparation of the infected nail with a laser beam.
摘要翻译: 用于局部治疗指甲疾病的方法,例如, 在用激光束制备感染的指甲后,甲真菌病。
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公开(公告)号:US06198869B1
公开(公告)日:2001-03-06
申请号:US09308096
申请日:1999-05-17
申请人: Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
发明人: Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
IPC分类号: G01N2100
CPC分类号: G01N21/648 , G01N21/05 , G01N21/7703 , G01N2021/0346
摘要: A device comprising a planar optical waveguide, consisting of a transparent carrier (40) and a wave-guiding layer (41), wherein the waveguide at least has a diffractive element (42) for coupling excitation radiation into the wave-guiding layer, and there is located on the wave-guiding layer a further, tightly sealing layer (43) made from a material which, at least at the support surface, is transparent both to the excitation radiation and to the evanescently excited radiation at least to the penetration depth of the evanescent field, and which, for an analysis sample, has, at least in a partial region of the guided excitation radiation, a cavity (45) which is open to the upper side or a cavity (6) which is closed to the upper side and connected by means of an inflow channel (2) and an outflow channel (3), the depth of the cavity corresponding at least to the penetration depth of the evanescent field, and wherein the diffractive element (42) is fully covered by the material of the layer (43) at least in the coupling-in region of the excitation radiation.
摘要翻译: 一种包括由透明载体(40)和波导层(41)组成的平面光波导的装置,其中所述波导至少具有用于将激发辐射耦合到波导层中的衍射元件(42),以及 位于波导层上的另一紧密密封层(43)由材料制成,所述材料至少在支撑表面上对于激发辐射和至少到穿透深度的消逝的辐射是透明的 ,并且对于分析样本,至少在被引导的激发辐射的部分区域中具有向上侧敞开的空腔(45)或与所述空腔(6)关闭的空腔(6),所述空腔 上侧并且通过流入通道(2)和流出通道(3)连接,所述空腔的深度至少对应于所述ev逝场的穿透深度,并且其中所述衍射元件(42)完全被 层的材料 (43)至少在激发辐射的耦合区域中。
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