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1.发明授权Means and method for field asymmetric ion mobility spectrometry combined with mass spectrometry 有权用于场非对称离子迁移光谱法与质谱联用的方法和方法公开(公告)号：US08399830B2
公开(公告)日：2013-03-19
申请号：US13115424
申请日：2011-05-25
CPC分类号： G01N27/624 , H01J49/0404 , Y10T29/49826
摘要： Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.
摘要翻译： 首先通过场不对称离子迁移谱（FAIMS）分析分析离子，然后通过质谱仪进行分析。 分析离子在接近大气压下产生，并通过介电毛细管转移到质量分析仪的真空系统中。 当通过毛细管时，通过FAIMS通过毛细管内壁上的电极分析离子。 通过在FAIMS分析仪中的通道和毛细管剩余部分中的通道之间提供平滑的几何过渡来实现改进的离子透过。
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2.发明申请MEANS AND METHOD FOR FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY 有权用于质谱分析的场非对称离子电离光谱的方法和方法公开(公告)号：US20120298860A1
公开(公告)日：2012-11-29
申请号：US13115424
申请日：2011-05-25
CPC分类号： G01N27/624 , H01J49/0404 , Y10T29/49826
摘要： Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.
摘要翻译： 首先通过场不对称离子迁移谱（FAIMS）分析分析离子，然后通过质谱仪进行分析。 分析离子在接近大气压下产生，并通过介电毛细管转移到质量分析仪的真空系统中。 当通过毛细管时，通过FAIMS通过毛细管内壁上的电极分析离子。 通过在FAIMS分析仪中的通道和毛细管剩余部分中的通道之间提供平滑的几何过渡来实现改进的离子透过。
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公开(公告)号：US08941055B2
公开(公告)日：2015-01-27
申请号：US13474009
申请日：2012-05-17
CPC分类号： G01N27/622
摘要： Ions with a predetermined ion mobility range are produced by filtering ions entrained in a stream of moving gas with two ion mobility low pass filters located consecutively in the gas stream. Each filter is formed by applying a DC electric field to the gas stream which causes the ions to move in a direction opposite to the gas flow. Ions are collected between the two filters and transferred to a detector or analyzing device. In one embodiment, the maximum field strength of the electric field barrier in the first ion mobility low pass filter is continued as a plateau of essentially constant field strength up to the electric field barrier in the second ion mobility low pass filter, which has a maximum field strength higher that the maximum field strength of the electric field barrier in the first ion mobility low pass filter.
摘要翻译： 具有预定离子迁移率范围的离子通过在气流中连续排列两个离子迁移率低通过滤器来过滤夹带在移动气体流中的离子而产生。 每个过滤器通过向气流施加DC电场而形成，其导致离子沿与气流相反的方向移动。 离子在两个过滤器之间收集并转移到检测器或分析装置。 在一个实施例中，第一离子迁移率低通滤波器中的电场势垒的最大场强作为基本上恒定场强的平台直到第二离子迁移率低通滤波器中的电场势垒持续，其具有最大值 场强比第一离子迁移率低通滤波器中的电场势垒的最大场强高。
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公开(公告)号：US08575542B1
公开(公告)日：2013-11-05
申请号：US13449436
申请日：2012-04-18
IPC分类号： H01J49/00
CPC分类号： H01J49/0054
摘要： The invention relates to a device for performing electron capture dissociation on multiply charged cations. Provided is an electron emitter which, upon triggering, emits a plurality of low energy electrons suitable for efficient electron capture reactions to occur. Further, the device contains a particle emitter being located proximate to the electron emitter and being capable, upon triggering, to emit a plurality of high energy charged particles substantially in a direction towards the electron emitter in order that the electron emitter receives a portion of the emitted plurality of high energy charged particles and emission of the plurality of low energy electrons is triggered. A volume capable of containing a plurality of multiply charged cations is located in opposing relation to the electron emitter such that the volume receives the plurality of low energy electrons upon emission as to allow electron capture dissociation to occur.
摘要翻译： 本发明涉及用于在多电荷阳离子上进行电子捕获离解的装置。 提供了一种电子发射器，其在触发时发射适于发生有效电子捕获反应的多个低能电子。 此外，该装置包含位于电子发射器附近的粒子发射器，并且能够在触发时基本上沿朝向电子发射器的方向发射多个高能量带电粒子，以使电子发射器接收一部分 发射多个高能量带电粒子并发射多个低能电子。 能够容纳多个多电荷阳离子的体积位于与电子发射体相对的关系中，使得体积在发射时接收多个低能电子以允许发生电子俘获解离。
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公开(公告)号：US08227748B2
公开(公告)日：2012-07-24
申请号：US12784473
申请日：2010-05-20
CPC分类号： H01J49/4295 , H01J49/0072 , H01J49/422
摘要： In a linear ion trap, ions with two polarities are confined radially via an RF potential between the rods comprising the trap. Axially, ions of at least one polarity are confined via DC potentials applied to the elements of the trap or electrodes at the ends of the trap whereas ions of the other polarity are axially confined by a combination of pseudopotentials and/or DC potentials.
摘要翻译： 在线性离子阱中，具有两个极性的离子通过包含捕获阱的棒之间的RF电位在径向上被限制。 轴向上，至少一个极性的离子通过施加到陷阱的元件上的DC电位而被限制，而另一极性的离子被赝势和/或DC电势的组合轴向限制。
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6.发明授权Selective ion mobility spectrometer formed from two consecutive mass selective filters 有权由两个连续质量选择滤光片形成的选择性离子迁移谱仪公开(公告)号：US08941054B2
公开(公告)日：2015-01-27
申请号：US13094128
申请日：2011-04-26
CPC分类号： H01J49/06 , G01N27/622 , G01N27/624
摘要： Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier.
摘要翻译： 具有预定范围的离子迁移率的离子通过用至少两个连续的离子迁移率高通和/或低通滤波器过滤输入离子而产生。 每个离子迁移率过滤器是通过夹杂在移动气体中的离子形成的，并且对离子施加直流电场，这导致离子沿与气流相反的方向移动。 当DC电场驱动离子抵抗气体流时，形成离子迁移率高通滤波器，而当气流驱动夹带的离子抵抗DC电场屏障时，形成离子迁移率低通滤波器。
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7.发明授权Spectrum acquisition modes for ion mobility spectrometers using trapped ions 有权使用捕获离子的离子迁移谱仪的光谱采集模式公开(公告)号：US08766176B2
公开(公告)日：2014-07-01
申请号：US13094102
申请日：2011-04-26
IPC分类号： H01J49/26
CPC分类号： G01N27/626
摘要： In an ion mobility spectrometer in which a gas flows through a gas-tight tube with a radially quadrupolar RF field therein and blows ions against a DC electric field barrier, a mobility scan with a mobility scale that is linear in time is obtained by holding the height of the DC electric field barrier constant while changing the pressure and temperature conditions of the flowing gas. Alternatively, the mobility scan is performed by holding the pressure and temperature conditions of the flowing gas constant and reducing the height of the DC electric field barrier non-linearly with respect to time.
摘要翻译： 在离子迁移谱仪中，气体通过其中具有径向四极RF场的气密管流动，并将离子吹向DC电场势垒，通过保持 直流电场势垒的高度在改变流动气体的压力和温度条件的同时。 或者，通过保持流动气体的压力和温度条件恒定并且相对于时间非线性地降低DC电场屏障的高度来执行移动扫描。
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公开(公告)号：US20120286156A1
公开(公告)日：2012-11-15
申请号：US13474009
申请日：2012-05-17
CPC分类号： G01N27/622
摘要： Ions with a predetermined ion mobility range are produced by filtering ions entrained in a stream of moving gas with two ion mobility low pass filters located consecutively in the gas stream. Each filter is formed by applying a DC electric field to the gas stream which causes the ions to move in a direction opposite to the gas flow. Ions are collected between the two filters and transferred to a detector or analyzing device. In one embodiment, the maximum field strength of the electric field barrier in the first ion mobility low pass filter is continued as a plateau of essentially constant field strength up to the electric field barrier in the second ion mobility low pass filter, which has a maximum field strength higher that the maximum field strength of the electric field barrier in the first ion mobility low pass filter.
摘要翻译： 具有预定离子迁移率范围的离子通过在气流中连续排列两个离子迁移率低通过滤器来过滤夹带在移动气体流中的离子而产生。 每个过滤器通过向气流施加DC电场而形成，其导致离子沿与气流相反的方向移动。 离子在两个过滤器之间收集并转移到检测器或分析装置。 在一个实施例中，第一离子迁移率低通滤波器中的电场势垒的最大场强作为基本上恒定场强的平台直到第二离子迁移率低通滤波器中的电场势垒持续，其具有最大值 场强比第一离子迁移率低通滤波器中的电场势垒的最大场强高。
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公开(公告)号：US20120223222A1
公开(公告)日：2012-09-06
申请号：US13037792
申请日：2011-03-01
IPC分类号： H01J49/22
CPC分类号： H01J49/427
摘要： In an RF quadrupole ion trap having electrodes to which RF voltages are applied, ions having m/z ratios outside of a predefined narrow range of charge-related masses m/z are removed from the trap by applying a DC voltage pulse to at least one of the trap electrodes to remove from the trap the ions with high values of charge-related masses. The DC voltage pulse is preferably applied in combination with a variation of the RF voltage amplitudes to simultaneously remove from the trap ions of low charge-related masses. The DC and RF voltage amplitudes are changed in such a manner that any excitation of ions having charge-related masses within the predefined range by frequency mixtures is avoided.
摘要翻译： 在具有施加有RF电压的电极的RF四极离子阱中，通过将DC电压脉冲施加到至少一个电压来从陷阱中除去具有预定的窄电荷相关质量m / z范围之外的m / z比的离子 的陷阱电极从陷阱中去除具有高电荷相关质量值的离子。 DC电压脉冲优选与RF电压幅度的变化相结合地同时从低电荷相关质量的俘获离子中去除。 DC和RF电压幅度以这样的方式改变，即避免了通过频率混合将具有电荷相关质量的离子激发在预定范围内。
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公开(公告)号：US20120273673A1
公开(公告)日：2012-11-01
申请号：US13094128
申请日：2011-04-26
CPC分类号： H01J49/06 , G01N27/622 , G01N27/624
摘要： Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier.
摘要翻译： 具有预定范围的离子迁移率的离子通过用至少两个连续的离子迁移率高通和/或低通滤波器过滤输入离子而产生。 每个离子迁移率过滤器是通过夹杂在移动气体中的离子形成的，并且对离子施加直流电场，这导致离子沿与气流相反的方向移动。 当DC电场驱动离子抵抗气体流时，形成离子迁移率高通滤波器，而当气流驱动夹带的离子抵抗DC电场屏障时，形成离子迁移率低通滤波器。
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