-
1.发明申请公开(公告)号：US20090169592A1
公开(公告)日：2009-07-02
申请号：US11894718
申请日：2007-08-20
Applicant: David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
Inventor： David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
CPC classification number: A61L27/54 , A61F2/30756 , A61K38/00 , A61L27/425 , A61L27/44 , C07K14/51
Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
-
2.发明授权Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects 有权成骨装置及其用于修复软骨内骨，骨软骨和软骨缺损的方法公开(公告)号：US08802626B2
公开(公告)日：2014-08-12
申请号：US13051928
申请日：2011-03-18
Applicant: David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
Inventor： David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
CPC classification number: A61L27/54 , A61F2/30756 , A61K38/00 , A61L27/425 , A61L27/44 , C07K14/51
Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and detects resulting from degenerative diseases such as osteochondritis dessicans.
Abstract translation: 本文公开了改进的成骨装置及其用于修复骨和软骨缺陷的方法。 与本领域中的装置相比，装置和方法促进了使用较少成骨蛋白的增强的稳定性的修复组织的形成。 本发明易于修复的缺陷包括但不限于：临界尺寸缺陷，非临界尺寸缺陷，非联合骨折，骨折，骨软骨缺损，软骨下缺陷，以及由退行性疾病如骨软骨炎干燥症引起的检测。
-
Patent Agency Ranking
公开(公告)号：US5049395A
公开(公告)日：1991-09-17
申请号：US521086
申请日：1990-05-09
Applicant: An-Cheng Chang
Inventor： An-Cheng Chang
CPC classification number: A61F13/15252 , A61K9/1652 , A61K9/1664 , A61K9/5047 , A61K9/5063 , A61L15/00 , A61L15/28 , A61L15/60 , A61F2013/51061 , A61F2013/530649 , A61F2013/530795 , A61F2013/53481 , A61F2013/8438 , A61F2013/8452
Abstract: A new controlled release vehicle which acts by breakdown of the entrapping material upon hydration has been developed. The preferred release vehicle is made of a carboxylated cellulose, e.g., carboxymethylcellulose, which is treated with a cross-linking agent such as aluminum ions and, preferably, a hydrophobicity agent such as acetic acid. The vehicle is broken down by a release agent, e.g., cellulase, which may be coated on the vehicle together with a coating agent, e.g., hydroxypropylcellulose. The vehicle is dried, entrapping the molecular to be entrapped, e.g., an enzyme, and hydration activates the cellulase which breaks down the carboxymethylcellulose, releasing the entrapped molecular.
Abstract translation: 已经开发了一种新的控制释放载体，其通过在水合时分解捕获材料而起作用。 优选的脱模剂由羧化纤维素例如羧甲基纤维素制成，其用交联剂如铝离子处理，优选疏水剂如乙酸处理。 载体通过脱模剂（例如纤维素酶）分解，纤维素酶可以与涂覆剂例如羟丙基纤维素一起涂覆在载体上。 将载体干燥，捕获待捕获的分子，例如酶，并且水合激活分解羧甲基纤维素的纤维素酶，释放截留的分子。
-
公开(公告)号：US4952550A
公开(公告)日：1990-08-28
申请号：US490356
申请日：1990-03-08
Applicant: Donald F. H. Wallach , An-Cheng Chang
Inventor： Donald F. H. Wallach , An-Cheng Chang
CPC classification number: A61L15/60 , A61F13/15252 , A61L15/00 , A61L15/28 , A61F2013/51061 , A61F2013/530649 , A61F2013/530795 , A61F2013/53481 , A61F2013/8438 , A61F2013/8452
Abstract: The present invention features methods of making absorbent material which exhibit excellent absorption for saline and other liquids as well as being biodegradable. The methods of the invention form a particulate which can be stored in dry form and rehydrated at any time. The particulate can be used to replace the presently utilized polyacrylate superabsorbers. The base material used in the methods of the invention is a carboxylated cellulosic material such as carboxymethylcellulose, preferably, a carboxymethylcellulose having a DS, or Degree of Substitution, of 0.5 or greater. The carboxylated cellulose material is reacted with two distinct agents; a cross-linking agent and a hydrophobicity agent to make the final absorbent.
Abstract translation: 本发明的特征在于制备吸收材料的方法，其对盐水和其它液体表现出优异的吸收性，并且是可生物降解的。 本发明的方法形成可以在任何时候以干燥形式储存并再水合的颗粒。 颗粒可用于替代目前使用的聚丙烯酸酯超吸收剂。 用于本发明方法的基材是羧化纤维素材料，例如羧甲基纤维素，优选具有0.5或更大的DS，或取代度的羧甲基纤维素。 羧化纤维素材料与两种不同的试剂反应; 交联剂和疏水剂以制成最终的吸收剂。
-
5.发明授权Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects 失效成骨装置及其用于修复软骨内骨，骨软骨和软骨缺损的方法公开(公告)号：US08372805B1
公开(公告)日：2013-02-12
申请号：US11894725
申请日：2007-08-20
Applicant: David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
Inventor： David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
CPC classification number: A61L27/54 , A61F2/30756 , A61K38/00 , A61L27/425 , A61L27/44 , C07K14/51
Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
Abstract translation: 本文公开了改进的成骨装置及其用于修复骨和软骨缺陷的方法。 与本领域中的装置相比，装置和方法促进了使用较少成骨蛋白的增强的稳定性的修复组织的形成。 本发明易于修复的缺陷包括但不限于：临界尺寸缺陷，非临界尺寸缺陷，非联合骨折，骨折，骨软骨缺损，软骨下缺陷以及由退行性疾病如骨软骨炎引起的缺陷。
-
6.发明申请OSTEOGENIC DEVICES AND METHODS OF USE THEREOF FOR REPAIR OF ENDOCHONDRAL BONE, OSTEOCHONDRAL AND CHONDRAL DEFECTS 有权骨质疏松的器官及其使用方法，用于修复内耳，骨质和骨缺损公开(公告)号：US20130149294A1
公开(公告)日：2013-06-13
申请号：US13051928
申请日：2011-03-18
Applicant: David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
Inventor： David C. Rueger , Marjorie M. Tucker , An-Cheng Chang
CPC classification number: A61L27/54 , A61F2/30756 , A61K38/00 , A61L27/425 , A61L27/44 , C07K14/51
Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and detects resulting from degenerative diseases such as osteochondritis dessicans.
Abstract translation: 本文公开了改进的成骨装置及其用于修复骨和软骨缺陷的方法。 与本领域中的装置相比，装置和方法促进了使用较少成骨蛋白的增强的稳定性的修复组织的形成。 本发明易于修复的缺陷包括但不限于：临界尺寸缺陷，非临界尺寸缺陷，非联合骨折，骨折，骨软骨缺损，软骨下缺陷，以及由退行性疾病如骨软骨炎干燥症引起的检测。
-
公开(公告)号：US5164191A
公开(公告)日：1992-11-17
申请号：US654327
申请日：1991-02-12
Applicant: S. Esmail Tabibi , An-Cheng Chang , Rajiv Mathur , Donald F. H. Wallach
Inventor： S. Esmail Tabibi , An-Cheng Chang , Rajiv Mathur , Donald F. H. Wallach
IPC: A61K9/127
CPC classification number: A61K9/1272 , Y10T428/2984
Abstract: The present invention features a method of making lipid vesicles and the lipid vesicles themselves made from monomeric and dimeric alkyds. These alkyds are esters made as a condensation product of a first reactant having at least one free hydroxyl group and a C.sub.12 -C.sub.20 fatty acids chain and a second reactant which is an aromatic acid chloride or anhydride. Preferred first reactants are esters of polyols and C.sub.12 -C.sub.20 fatty acids, ethers of polyols and C.sub.12 -C.sub.20 fatty acids, and C.sub.12 -C.sub.20 fatty alcohols.
Abstract translation: 本发明的特征在于制备脂质囊泡的方法，脂质囊泡本身由单体和二聚醇酸树脂制成。 这些醇酸树脂是作为具有至少一个游离羟基的第一反应物和C 12 -C 20脂肪酸链和作为芳族酰氯或酸酐的第二反应物的缩合产物的酯。 优选的第一反应物是多元醇和C 12 -C 20脂肪酸的酯，多元醇和C 12 -C 20脂肪酸的醚和C 12 -C 20脂肪醇。
-
-
-
-
-
-
Search Results
7
records
(took 0.022 seconds)
