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1.发明授权Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same 失效马鞭草提取物，提取工艺和含有相同的药物组合物公开(公告)号：US07621740B2
公开(公告)日：2009-11-24
申请号：US11682602
申请日：2007-03-06
Applicant: Robert Mills , Rajiv Mathur , Nadya Lawrence
Inventor： Robert Mills , Rajiv Mathur , Nadya Lawrence
IPC: A61K36/00
CPC classification number: A61Q19/00 , A61K8/14 , A61K8/97 , A61K9/0014 , A61K9/127 , A61K36/29 , A61Q19/007
Abstract: A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system is described. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. A process for obtaining an extract of Mahonia aquifolium is also disclosed.
Abstract translation: 描述了在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 还公开了一种获得大洋沼泽提取物的方法。
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公开(公告)号：US6087393A
公开(公告)日：2000-07-11
申请号：US329608
申请日：1999-06-10
Applicant: Rajiv Mathur
Inventor： Rajiv Mathur
IPC: A61K31/34
CPC classification number: A61K31/34
Abstract: The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid in the mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol , and stabilizing and solubility assisting agents as well.
Abstract translation: 本发明的特征在于通过将游离的1-抗坏血酸分散在混合的二醇载体和含有抗坏血酸的溶液在混合的二醇溶液中而使游离的1-抗坏血酸免于氧化的方法。 混合乙二醇载体含有至少丙二醇和丁二醇的混合物，但也可以含有其它二醇，如聚乙二醇，以及稳定和助溶剂。
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公开(公告)号：US5643600A
公开(公告)日：1997-07-01
申请号：US583667
申请日：1996-01-05
Applicant: Rajiv Mathur
Inventor： Rajiv Mathur
CPC classification number: A61K8/922 , A61K8/14 , A61K9/1272 , A61Q19/00 , A61Q19/08 , A61Q5/12 , Y10T428/2984
Abstract: Disclosed are oil-filled paucilamellar lipid vesicles containing at least one non-phospholipid amphiphile as the primary lipid of the vesicle bilayers and avocado oil unsaponifiables. The vesicles are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.
Abstract translation: 公开了含有至少一种非磷脂两亲物作为囊泡双层的主要脂质和鳄梨油不皂化物的油充满的小囊脂质囊泡。 囊泡对于递送皮肤病学，化妆品和药物制剂是特别有用的。 还公开了这些囊泡的制造方法。
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公开(公告)号：US5256422A
公开(公告)日：1993-10-26
申请号：US909112
申请日：1992-07-08
Applicant: Elizabeth C. Albert , Donald F. H. Wallach , Rajiv Mathur
Inventor： Elizabeth C. Albert , Donald F. H. Wallach , Rajiv Mathur
CPC classification number: A61K8/064 , A23D7/0056 , A61K8/14 , A61K9/113 , A61K9/1272 , A61Q19/00 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/943 , Y10T428/2984
Abstract: The present invention features water-in-oil emulsions having intact lipid vesicles dispersed in the water or aqueous phase. Methods of making the emulsions are also disclosed. The preferred vesicles for use in the emulsions are paucilamellar lipid vesicles, most preferably those having nonionic amphiphiles as their major structural component. The water-in-oil emulsions are useful in cosmetics, pharmaceuticals, and foods such as margarine.
Abstract translation: 本发明的特征在于具有分散在水或水相中的完整脂质囊泡的油包水乳液。 还公开了制备乳液的方法。 用于乳液的优选囊泡是微囊脂质囊泡，最优选的是具有非离子两亲物作为其主要结构组分的囊泡。 油包水乳液可用于化妆品，药物和人造黄油等食品。
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5.发明申请公开(公告)号：US20150220927A1
公开(公告)日：2015-08-06
申请号：US14129543
申请日：2013-09-25
Applicant: Ned M. SMITH , Thomas J. SAWICKI , Rajiv MATHUR , Tolga ACAR , Yuriy BULYGIN , Thomas G. WILLIS , Intel Corporation
Inventor： Ned M. Smith , Thomas J. Sawicki , Rajiv Mathur , Tolga Acar , Yuriy Bulygin , Thomas G. Willis
CPC classification number: G06Q20/4016 , G06Q30/06 , G06Q40/08 , H04L67/10
Abstract: Techniques and mechanisms to provide indemnification for a transaction involving communications between networked devices. In an embodiment, attestation logic of a first device sends to a second device attestation information to indicate a trustworthiness level of first device. Based on the attestation information, indemnification logic of the second device determines an indemnification value representing a cost of an indemnification for a first transaction. Indemnification logic of the first device receives the indemnification value and determines, based on the indemnification value, whether a participation in the transaction is to take place.
Abstract translation: 为涉及网络设备之间通信的交易提供赔偿的技术和机制。 在一个实施例中，第一设备的认证逻辑发送到第二设备认证信息以指示第一设备的可信赖级别。 基于认证信息，第二设备的赔偿逻辑确定代表第一交易的赔偿成本的赔偿价值。 第一设备的赔偿逻辑接收赔偿价值，并根据赔偿价值确定是否要进行交易。
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Patent Agency Ranking
公开(公告)号：US5439967A
公开(公告)日：1995-08-08
申请号：US148952
申请日：1993-11-08
Applicant: Rajiv Mathur
Inventor： Rajiv Mathur
IPC: A61K8/14 , A61K8/92 , A61K9/127 , A61K47/06 , A61K47/14 , A61Q5/12 , A61Q19/00 , A61Q19/08 , B01J13/02
CPC classification number: A61Q19/00 , A61K8/14 , A61K8/922 , A61K9/1272 , A61Q19/08 , A61Q5/12 , Y10T428/2984
Abstract: Disclosed are lipid vesicles containing a blend of amphiphiles, including propylene glycol stearate, in the lipid bilayers. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.
Abstract translation: 公开了在脂质双层中含有两亲物（包括丙二醇硬脂酸酯）的混合物的脂质囊泡。 囊泡可以具有水或油填充的中心腔，并且特别可用于递送皮肤病学，化妆品和药物制剂。 还公开了这些囊泡的制造方法。
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公开(公告)号：US5260065A
公开(公告)日：1993-11-09
申请号：US761253
申请日：1991-09-17
Applicant: Rajiv Mathur , Donald F. H. Wallach
Inventor： Rajiv Mathur , Donald F. H. Wallach
CPC classification number: A61Q19/00 , A61K8/14 , A61K8/922 , A61K9/1272 , A61Q19/08 , A61Q5/12 , Y10T428/2984
Abstract: A new class of lipid vesicles having a blend of two lipids, a primary lipid and a secondary lipid, has been developed. The primary lipid, which forms the greatest proportion of lipid by weight, will not form vesicles nor preferably, even a lamellar phase, without addition of the secondary lipid. Preferably primary lipids are C.sub.12 -C.sub.18 fatty alcohols, C.sub.12 -C.sub.18 glycol monoesters, and C.sub.12 -C.sub.18 glyceryl mono- and diesters.
Abstract translation: 已经开发了一类具有两种脂质，一种主要脂质和二级脂质的混合物的脂质囊泡。 形成脂质重量比例最大的主要脂质不会形成囊泡，也不会优选甚至层状相，而不添加次级脂质。 初级脂质优选为C12-C18脂肪醇，C12-C18二醇单酯和C12-C18甘油单酯和二酯。
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公开(公告)号：US5234915A
公开(公告)日：1993-08-10
申请号：US587240
申请日：1990-09-24
Applicant: Rajiv Mathur , Donald F. H. Wallach
Inventor： Rajiv Mathur , Donald F. H. Wallach
CPC classification number: C08B15/005 , A61F13/15252 , A61K47/38 , A61K47/4823 , A61L15/28 , A61L26/0023 , A61L26/0066 , A61L26/009 , A61F2013/51061 , A61F2013/530649 , A61F2013/530795 , A61F2013/53481 , A61F2013/8438 , A61F2013/8452 , A61L2300/406 , A61L2300/602 , A61L2300/802
Abstract: A new gel-like composition of matter containing a complex carbohydrate with a high degree of carboxyl substitution cross-linked by an organic cross-linker has been developed. The cross-linkers have complex ring structures, e.g., polynuclear or heterocyclic compounds, which permit development of two distinct partial positive charges under conditions where a carbohydrate is negatively charged. Antibiotics are the preferred cross-linking agents and a method of sustained release of the antibodies is also disclosed.
Abstract translation: 已经开发了含有通过有机交联剂交联的高度羧基取代的复合碳水化合物的新的凝胶状组合物。 交联剂具有复杂的环结构，例如多核或杂环化合物，其允许在碳水化合物带负电的条件下开发两种不同的部分正电荷。 抗生素是优选的交联剂，还公开了抗体的持续释放的方法。
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9.发明授权Lipid vesicles having N,N-dimethylamide derivatives as their primary lipid 失效具有N，N-二甲酰胺衍生物作为主要脂质的脂质体
公开(公告)号：US5213805A
公开(公告)日：1993-05-25
申请号：US735645
申请日：1991-07-25
Applicant: Donald F. H. Wallach , Rajiv Mathur
Inventor： Donald F. H. Wallach , Rajiv Mathur
CPC classification number: A61K9/1272 , A01N47/48 , Y10T428/2984
Abstract: The present invention concerns lipid vesicles having dimethylamides as their primary structural lipid. Preferred dimethylamides useful in the invention are DMATO and DMASO oils. These vesicles are useful as carriers of water immiscible oily material such as fungicides. In a most preferred aspect, the invention has DMATO vesicles with TCMTB as a fungicide in trapped therein. The vesicles can be made rapidly and provide aqueous dispersion of these materials without the need for additional organic solvents.
Abstract translation: 本发明涉及具有二甲酰胺作为其主要结构脂质的脂质囊泡。 用于本发明的优选的二甲基酰胺是DMATO和DMASO油。 这些囊泡可用作水不混溶油性物质如杀真菌剂的载体。 在最优选的方面，本发明具有DMATO囊泡，其中TCMTB作为杀真菌剂被捕获。 可以快速制备囊泡，并提供这些材料的水性分散体，而不需要额外的有机溶剂。
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10.发明申请MAHONIA AQUIFOLIM EXTRACT, EXTRACTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 失效MAHONIA AQUIFOLIM提取物，提取方法和含有其的药物组合物公开(公告)号：US20070148226A1
公开(公告)日：2007-06-28
申请号：US11682602
申请日：2007-03-06
Applicant: Robert Mills , Rajiv Mathur , Nadya Lawrence
Inventor： Robert Mills , Rajiv Mathur , Nadya Lawrence
IPC: A61K36/185 , A61K9/127
CPC classification number: A61Q19/00 , A61K8/14 , A61K8/97 , A61K9/0014 , A61K9/127 , A61K36/29 , A61Q19/007
Abstract: The present invention provides a skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. The invention further provides a process for obtaining an extract of Mahonia aquifolium.
Abstract translation: 本发明提供一种在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 本发明还提供了一种获得马鞭草提取物的方法。
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