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公开(公告)号：US08637815B2
公开(公告)日：2014-01-28
申请号：US13375150
申请日：2010-05-27
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： Methods and analysers useful for time of flight mass spectrometry are provided. A method of separating charged particles comprises the steps of: providing an analyser comprising two opposing mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner and defining therebetween an analyser volume, the mirrors creating an electrical field within the analyser volume comprising opposing electrical fields along z, the strength along z of the electrical field being a minimum at a plane z=0; causing a beam of charged particles to fly through the analyser, orbiting around the z axis within the analyser volume, reflecting from one mirror to the other at least once thereby defining a maximum turning point within a mirror; the strength along z of the electrical field at the maximum turning point being X and the absolute strength along z of the electrical field being less than |X|/2 for not more than ⅔ of the distance along z between the plane z=0 and the maximum turning point in each mirror; separating the charged particles according to their flight times; and ejecting at least some of the charged particles having a plurality of m/z from the analyser or detecting the at least some of charged particles having a plurality of m/z, the ejecting or detecting being performed after the particles have undergone the same number of orbits around the axis z.
摘要翻译： 提供了可用于飞行时间质谱的方法和分析仪。 分离带电粒子的方法包括以下步骤：提供包括两个相对的反射镜的分析器，每个反射镜包括沿着轴线z细长的内部和外部场限定电极系统，外部系统围绕内部并且在其间限定分析器体积， 在分析器体积内产生包括沿着z的相对电场的电场，在z = 0的平面处电场z的强度是最小的; 使得带电粒子束飞过分析器，围绕分析器体积内的z轴轨道运动，从一个反射镜至另一个反射镜至少一次，从而限定了反射镜内的最大转折点; 在最大转折点处的电场z的强度为X，电场z的绝对强度小于| X | / 2，不超过z = z = 0和每个镜中的最大转折点; 根据飞行时间分离带电粒子; 并且从分析器中排出具有多个m / z的至少一些带电粒子或者检测至少一些具有多个m / z的带电粒子，在粒子经历相同数目之后执行喷射或检测 绕z轴的轨道。
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公开(公告)号：US20120091332A1
公开(公告)日：2012-04-19
申请号：US13375187
申请日：2010-05-27
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyser; and separating the charged particles according to their flight time. An analyser for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam. An array of arcuate focusing lenses may be used which are located at substantially the same z coordinate, the arcuate focusing lenses in the array being spaced apart in the arcuate direction and the array extending at least partially around the z axis, thereby constraining the arcuate divergence of the beam a plurality of times as it flies through the analyser.
摘要翻译： 提供了一种使用分析器分离带电粒子的方法，所述方法包括：使带电粒子束飞过分析器，并在分析器内沿分析器轴线（z）的方向进行至少一次全部振荡， 同时沿着主飞行路径围绕轴线（z）绕行驶; 约束梁在其穿过分析器时的弓形发散; 并根据飞行时间分离带电粒子。 还提供了用于执行该方法的分析器。 优选地使用至少一个弧形聚焦透镜来限制发散，其可以包括位于光束的任一侧的一对相对的电极。 可以使用位于基本上相同z坐标处的弧形聚焦透镜阵列，阵列中的弧形聚焦透镜在弧形方向上间隔开，并且阵列至少部分地围绕z轴延伸，从而约束弓形散度 的光束多次通过分析仪。
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公开(公告)号：US20100059673A1
公开(公告)日：2010-03-11
申请号：US12514683
申请日：2007-11-14
CPC分类号： H01J49/0081 , H01J49/0031
摘要： This invention relates to a method of operating a charged particle trap in which ions undergo multiple reflections back and forth and/or follow a closed orbit around, usually, a set of electrodes. The invention allows high-performance isolation of multiple ion species for subsequent detection or fragmentation by deflecting ions out of the ion trap according to a timing scheme calculated with reference to the ions' periods of oscillation within the ion trap.
摘要翻译： 本发明涉及一种操作带电粒子捕集器的方法，其中离子通常在一组电极周围进行多次反射和/或跟随闭合轨道。 本发明允许通过根据离子陷阱内的离子振荡周期计算的定时方案将离子偏离离子阱，从而高效隔离多个离子物质用于随后的检测或碎裂。
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公开(公告)号：US07075065B2
公开(公告)日：2006-07-11
申请号：US10925192
申请日：2004-08-24
IPC分类号： H01L49/40
CPC分类号： H01J49/405 , H01J49/004
摘要： Mass spectrometry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field free region 120, means to fragment the molecules, a second time of flight means and a large area detector 160. The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions front the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.
摘要翻译： 质谱装置105包括离子源110的串行排列，第一飞行时间装置，无场区域120，分解分子的装置，第二时间飞行装置和大面积检测器160。 第二次飞行装置包括离子镜150，离子镜150被布置成产生反射基本上二次场。 第一次飞行装置被设置成提供空间聚焦，伴随着离子在离子反射镜150的入口处或附近的时间聚焦。 提供用于在飞行装置的第一时间前面分离离子的装置可以是碰撞室140或场自由区域220或在第一次飞行装置中。 分解分子的方法具有与入射到离子镜150的电位不同的电位，并且检测器160的检测表面安装在离子反射镜150的时间焦点表面中。
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公开(公告)号：US10074528B2
公开(公告)日：2018-09-11
申请号：US13994312
申请日：2011-12-15
CPC分类号： H01J49/025 , H01J49/0036
摘要： The invention provides a data acquisition system and method for detecting ions in a mass spectrometer, comprising: a detection system for detecting ions comprising two or more detectors for outputting two or more detection signals in separate channels in response to ions arriving at the detection system; and a data processing system for receiving and processing the detection signals in separate channels of the data processing system and for merging the processed detection signals to construct a mass spectrum; wherein the processing in separate channels comprises removing noise from the detection signals by applying a threshold to the detection signals. The detection signals are preferably produced in response to the same ions, the signals being shifted in time relative to each other. The invention is suitable for a TOF mass spectrometer.
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6.发明授权Ion focussing and conveying device and a method of focussing and conveying ions 有权离子聚焦和输送装置以及聚焦和输送离子的方法公开(公告)号：US07375344B2
公开(公告)日：2008-05-20
申请号：US11107617
申请日：2005-04-15
CPC分类号： H01J49/065
摘要： An ion focusing and conveying device 10 comprises a plurality of electrodes 12 in series. Means is provided to apply a first alternating voltage waveform to each electrode 12, the phase of the alternating voltage in the first waveform is applied to each electrode 12 in the series being ahead of the phase of the first alternating voltage waveform applied to the preceding electrode 12 in the series by less than 180°, preferably by 90° or less, such that ions are focused onto an axis of travel and impelled along the series of electrodes 12.
摘要翻译： 离子聚焦和输送装置10包括串联的多个电极12。 提供了用于向每个电极12施加第一交流电压波形的装置，将第一波形中的交流电压的相位以串联的每个电极12施加在施加到前一个电极的第一交流电压波形的相位之前 12系列小于180°，优选为90°或更小，使得离子聚焦到行进轴线上并沿着该系列电极12推动。
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7.发明授权Ion focussing and conveying device and a method of focussing the conveying ions 有权离子聚焦和输送装置以及聚焦输送离子的方法公开(公告)号：US06894286B2
公开(公告)日：2005-05-17
申请号：US10416936
申请日：2001-11-23
CPC分类号： H01J49/065
摘要： An ion focussing and conveying device 10 comprises a plurality of electrodes 12 in series. Means is provided to apply a first alternating voltage waveform to each electrode 12, the phase of the alternating voltage in the first waveform is applied to each electrode 12 in the series being ahead of the phase of the first alternating voltage waveform applied to the preceding electrode 12 in the series by less than 180°, preferably by 90° or less, such that ions are focussed onto an axis of travel and impelled along the series of electrodes 12.
摘要翻译： 离子聚焦和输送装置10包括串联的多个电极12。 提供了用于向每个电极12施加第一交流电压波形的装置，将第一波形中的交流电压的相位以串联的每个电极12施加在施加到前一个电极的第一交流电压波形的相位之前 12系列小于180°，优选为90°或更小，使得离子聚焦在行进轴线上并沿着该系列电极12推动。
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公开(公告)号：US06781122B2
公开(公告)日：2004-08-24
申请号：US10221378
申请日：2002-11-25
IPC分类号： H01L4940
CPC分类号： H01J49/405 , H01J49/004
摘要： Mass spectrometry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field free region 120, means to fragment the molecules, a second time of flight means and a large area detector 160 The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions from the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.
摘要翻译： 质谱装置105包括离子源110的串行排列，第一飞行时间装置，无场区域120，分裂分子的装置，第二飞行时间装置和大面积检测器160第二飞行时间装置 包括离子镜150，离子镜150被布置成产生反射基本上二次场。 第一次飞行装置被设置成提供与离子在离子反射镜150的入口处或附近的时间聚焦的空间聚焦。提供用于从第一次飞行装置分离离子的装置可以是碰撞单元140或 在现场自由区域220或在第一次飞行中的装置。 分解分子的方法具有与入射到离子镜150的电位不同的电位，并且检测器160的检测表面安装在离子反射镜150的时间焦点表面中。
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9.发明授权FAIMS apparatus and method comprising an ion separation channel of helical shape 有权FAIMS装置和方法包括螺旋形状的离子分离通道公开(公告)号：US08952322B2
公开(公告)日：2015-02-10
申请号：US13822834
申请日：2011-09-08
CPC分类号： B03C3/00 , G01N27/624
摘要： A method and apparatus for high resolution separation of ions based on their high field and low-field mobility properties is described.An elongate ion separation channel is defined by a plurality of channel walls. First and second channel walls have first and second spaced ion separation electrode assemblies respectively. A power supply applies a periodic asymmetric potential to one or both of the electrode assemblies so as to generate a periodically asymmetric electric field in the channel for ion mobility separation. The channel walls define an ion separation channel of substantially helical shape.
摘要翻译： 描述了基于它们的高场和低场迁移率特性来高分离离子分离的方法和装置。 细长离子分离通道由多个通道壁限定。 第一和第二通道壁分别具有第一和第二间隔离子分离电极组件。 电源对一个或两个电极组件施加周期性不对称电位，以便在用于离子迁移率分离的通道中产生周期性不对称电场。 通道壁限定了大致螺旋形状的离子分离通道。
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10.发明授权Method and apparatus for improving the throughput of a charged particle analysis system 有权用于提高带电粒子分析系统的通过量的方法和装置公开(公告)号：US08916819B2
公开(公告)日：2014-12-23
申请号：US13876794
申请日：2011-09-29
CPC分类号： H01J49/0027 , H01J49/0031 , H01J49/06 , H01J49/062
摘要： A method of increasing ion throughput within an accumulator, an energy lift and a pulsed ion extractor, operated in that order upon a batch of ions, comprising the steps of: firstly loading a batch of ions into the accumulator; secondly changing the electrical potential of the energy lift to raise the energy of the batch of ions contained therein; and thirdly ejecting the batch of ions from the pulsed ion extractor; and wherein: the energy lift is a separate device from the accumulator and the pulsed ion extractor, and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator and/or a previous batch of ions is prepared for ejection in the pulsed ion extractor; or the energy lift is incorporated into the pulsed ion extractor and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator; or the energy lift is incorporated into the accumulator and whilst changing the electrical potential in the second step a previous batch of ions is prepared for ejection in the pulsed ion extractor. A charged particle analyzer system is also provided.
摘要翻译： 一种增加蓄电池内的离子通量的方法，能量提升和脉冲离子提取器，其以一批离子的顺序操作，包括以下步骤：首先将一批离子加载到蓄电池中; 二次改变能量升高的电位，以提高其中所含的一批离子的能量; 第三次从脉冲离子提取器中排出一批离子; 并且其中：所述能量提升是与所述蓄能器和所述脉冲离子提取器分离的装置，并且在第二步骤中改变电势的同时，将新批次的离子加载到所述储存器中和/或先前批次的离子准备 在脉冲离子提取器中喷射; 或者能量提升被并入到脉冲离子提取器中，并且在第二步骤中改变电势的同时，将新批次的离子加载到蓄能器中; 或者能量提升被并入蓄能器中，并且在第二步骤中改变电位的同时，准备先前的一批离子以在脉冲离子提取器中喷射。 还提供带电粒子分析仪系统。
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