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    Imidazolone phenylalanine derivatives
    3.
    发明授权
    Imidazolone phenylalanine derivatives 失效
    咪唑啉酮苯丙氨酸衍生物

    公开(公告)号：US08030328B2

    公开(公告)日：2011-10-04

    申请号：US11438659

    申请日：2006-05-22

    申请人： Frank Stappenbeck ,  Andrei Konradi ,  Jacek Jagodzinski ,  Christopher M. Semko ,  Ying-zi Xu ,  Jenifer L. Smith ,  Kassandra Rossiter

    发明人： Frank Stappenbeck ,  Andrei Konradi ,  Jacek Jagodzinski ,  Christopher M. Semko ,  Ying-zi Xu ,  Jenifer L. Smith ,  Kassandra Rossiter

    IPC分类号： A61K31/4166 ,  A61K31/437 ,  C07D235/26 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof wherein the variables A, n, R5, R21-R24 and Q are defined herein. These compounds bind VLA-4. Certain of these compound also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

    摘要翻译： 公开了下式的化合物及其药学上可接受的盐，其中变量A，n，R5，R21-R24和Q在本文中定义。 这些化合物结合VLA-4。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。

    PYRIMIDINYL SULFONAMIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
    4.
    发明申请
    PYRIMIDINYL SULFONAMIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效
    VLA-4介导的抑制白蛋白粘合的吡咯烷酮磺酰胺化合物

    公开(公告)号：US20080058357A1

    公开(公告)日：2008-03-06

    申请号：US11679042

    申请日：2007-02-26

    申请人： Jenifer Smith ,  Christopher Semko ,  Ying-Zi Xu ,  Andrei Konradi

    发明人： Jenifer Smith ,  Christopher Semko ,  Ying-Zi Xu ,  Andrei Konradi

    IPC分类号： C07D401/12 ,  A61K31/506 ,  A61P37/00

    CPC分类号： C07D239/50

    摘要： Disclosed are compounds, which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a human or animal subject such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, Crohn's disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

    摘要翻译： 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 此类化合物可用于治疗人或动物受试者如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，克罗恩病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。