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    Compositions and methods for treating lung disease and injury
    1.
    发明授权
    Compositions and methods for treating lung disease and injury 有权
    用于治疗肺部疾病和损伤的组合物和方法

    公开(公告)号：US09205100B2

    公开(公告)日：2015-12-08

    申请号：US14002660

    申请日：2012-03-01

    申请人： Andrew E. Gelman ,  Elena Feinstein ,  Svetlana Adamsky ,  Igor Mett ,  Hagar Kalinski ,  Sharon Avkin-Nachum

    发明人： Andrew E. Gelman ,  Elena Feinstein ,  Svetlana Adamsky ,  Igor Mett ,  Hagar Kalinski ,  Sharon Avkin-Nachum

    IPC分类号： C12N15/11 ,  A61K31/713 ,  C12N15/113

    CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2310/3521

    摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.

    摘要翻译： 本文公开了治疗哺乳动物肺疾病，病症和损伤的治疗方法，包括治疗急性呼吸窘迫综合征（ARDS），急性肺损伤，肺纤维化（特发性），博来霉素诱导的肺纤维化，机械通气机诱导的肺损伤，慢性 阻塞性肺疾病（COPD），慢性支气管炎，肺气肿，肺移植后闭塞性细支气管炎和肺移植引起的急性移植物功能障碍，包括治疗，预防或预防原发性移植物衰竭，缺血再灌注损伤，再灌注损伤，再灌注水肿， 同种异体移植功能障碍，肺再植入反应，肺移植后闭塞性细支气管炎和/或器官移植后特别是肺移植中的原发性移植物功能障碍（PGD），包括下调TLR2基因或TLR2基因和TLR4基因。 本文提供了用于治疗肺部疾病，病症和损伤的组合物，方法和试剂盒。

    COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 有权
    用于治疗肺部疾病和伤害的组合物和方法

    公开(公告)号：US20140005253A1

    公开(公告)日：2014-01-02

    申请号：US14002660

    申请日：2012-03-01

    申请人： Andrew E. Gelman ,  Elena Feinstein ,  Svetlana Adamsky ,  Igor Mett ,  Hagar Kalinski ,  Sharon Avkin-Nachum

    发明人： Andrew E. Gelman ,  Elena Feinstein ,  Svetlana Adamsky ,  Igor Mett ,  Hagar Kalinski ,  Sharon Avkin-Nachum

    IPC分类号： A61K31/713

    CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2310/3521

    摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.

    摘要翻译： 本文公开了治疗哺乳动物肺疾病，病症和损伤的治疗方法，包括治疗急性呼吸窘迫综合征（ARDS），急性肺损伤，肺纤维化（特发性），博来霉素诱导的肺纤维化，机械通气机诱导的肺损伤，慢性 阻塞性肺疾病（COPD），慢性支气管炎，肺气肿，肺移植后闭塞性细支气管炎和肺移植引起的急性移植物功能障碍，包括治疗，预防或预防原发性移植物衰竭，缺血再灌注损伤，再灌注损伤，再灌注水肿， 同种异体移植功能障碍，肺再植入反应，肺移植后闭塞性细支气管炎和/或器官移植后特别是肺移植中的原发性移植物功能障碍（PGD），包括下调TLR2基因或TLR2基因和TLR4基因。 本文提供了用于治疗肺部疾病，病症和损伤的组合物，方法和试剂盒。