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公开(公告)号：US08822417B2
公开(公告)日：2014-09-02
申请号：US13463944
申请日：2012-05-04
申请人： Jan Terje Andersen , Bjorn Dalhus , Inger Sandlie , Jason Cameron , Andrew Plumridge , Esben Peter Friis , Karen Delahay
发明人： Jan Terje Andersen , Bjorn Dalhus , Inger Sandlie , Jason Cameron , Andrew Plumridge , Esben Peter Friis , Karen Delahay
CPC分类号： C07K14/765 , C07K2319/00
摘要： Variants of a parent albumin having altered plasma half-life compared with a parent albumin are described. Fusion polypeptides and conjugates including the variant albumin are also described. Embodiments include, but are not limited to, a polypeptide which is a variant of albumin, including one or more alterations at one or more positions corresponding to 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119 and 120 in SEQ ID NO: 2.
摘要翻译： 描述了与亲本白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。 还描述了融合多肽和包含变体白蛋白的缀合物。 实施方案包括但不限于作为白蛋白变体的多肽，包括一个或多个在104,105,106,107,108,109,110,111,112,113,118,106,101,101,113,118,101,101,111,113,118,118,118,118,118,118,118,118,118,118,118,118,118,118,118,118,118,11 114,115,116,117,118,119和120在SEQ ID NO：2中。
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公开(公告)号：US20120322739A1
公开(公告)日：2012-12-20
申请号：US13463944
申请日：2012-05-04
申请人： Jan Terje Andersen , Bjorn Dalhus , Inger Sandlie , Jason Cameron , Andrew Plumridge , Esben Peter Friis , Karen Delahay
发明人： Jan Terje Andersen , Bjorn Dalhus , Inger Sandlie , Jason Cameron , Andrew Plumridge , Esben Peter Friis , Karen Delahay
IPC分类号： A61K38/38 , C12N15/62 , C12N15/14 , C12P21/02 , C12N15/63 , C12N1/19 , C12N5/10 , C07K14/765 , A61P7/00 , B82Y5/00
CPC分类号： C07K14/765 , C07K2319/00
摘要： The invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
摘要翻译： 本发明涉及与母体白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。 本发明还涉及包含所述变体白蛋白的融合多肽和缀合物。
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公开(公告)号：US20100221398A1
公开(公告)日：2010-09-02
申请号：US12601056
申请日：2008-06-06
IPC分类号： A23L3/3499 , C07C57/10 , C07C63/64 , C09K15/06
CPC分类号： A23L2/44 , A23L3/3463 , A23L3/3499 , A23L3/3508
摘要： The invention relates to use of a compound of Formula (I) as a preservative, or to enhance the anti-mould efficacy of another preservative and a product comprising a compound of Formula (I), wherein: the second carbon is optionally substituted; the bond between R and the second carbon is unsaturated; R is a C1 to C20 alkyl, aryl, alkaryl, alkenyl or alkynyl; and wherein R may be optionally substituted; Z is H or OH; and when Z is OH, the bond between R and the second carbon is a triple bond.
摘要翻译： 本发明涉及式（I）化合物作为防腐剂的用途，或提高另一种防腐剂和包含式（I）化合物的产品的抗霉菌功效，其中：第二碳任选被取代; R和第二碳之间的键是不饱和的; R是C1-C20烷基，芳基，烷芳基，烯基或炔基; 并且其中R可以任选被取代; Z是H或OH; 当Z为OH时，R与第二碳之间的键为三键。
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公开(公告)号：US20130225496A1
公开(公告)日：2013-08-29
申请号：US13882653
申请日：2011-11-01
IPC分类号： C07K14/76 , A61K47/48 , C07K14/765
CPC分类号： C07K14/76 , A61K47/643 , C07K14/765 , C07K2319/31
摘要： The invention relates to variants of albumin. The invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of preparing the variants and to methods of using the variants.
摘要翻译： 本发明涉及白蛋白的变体。 本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含所述多核苷酸的宿主细胞; 以及制备变体的方法和使用变体的方法。
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公开(公告)号：US10233228B2
公开(公告)日：2019-03-19
申请号：US13640235
申请日：2011-04-08
申请人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
IPC分类号： C07K14/765
摘要： The application discloses albumin derivatives comprising or consisting of domain III and at least one further domain wherein the derivative or variant is not a naturally occurring albumin derivative or variant. The derivatives may be used in conjugates and fusion polypeptides.
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公开(公告)号：US08748380B2
公开(公告)日：2014-06-10
申请号：US13504326
申请日：2010-11-01
申请人： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
IPC分类号： A61K38/38 , A61K47/48 , C07K14/76 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H21/04 , C12P21/06 , C12P21/04
CPC分类号： C07K14/765 , A61K45/06 , C07K14/54 , C07K2319/20 , C07K2319/31
摘要： The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
摘要翻译： 本发明涉及与母体白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。 本发明还涉及包含所述变体白蛋白的融合多肽和缀合物。
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公开(公告)号：US20130028930A1
公开(公告)日：2013-01-31
申请号：US13640235
申请日：2011-04-08
申请人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
IPC分类号： C07K19/00 , A61K38/38 , C12N1/19 , A61K39/385 , A61P31/14 , A61P31/20 , C12N15/63 , C12N9/96
CPC分类号： C07K14/765 , C07K2319/00
摘要： The application discloses albumin derivatives comprising or consisting of domain III and at least one further domain wherein the derivative or variant is not a naturally occurring albumin derivative or variant. The derivatives may be used in conjugates and fusion polypeptides.
摘要翻译： 本申请公开了包含或由结构域III和至少一个其它结构域组成的白蛋白衍生物，其中该衍生物或变体不是天然存在的白蛋白衍生物或变体。 衍生物可用于缀合物和融合多肽。
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公开(公告)号：US20120220530A1
公开(公告)日：2012-08-30
申请号：US13504326
申请日：2010-11-01
申请人： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
CPC分类号： C07K14/765 , A61K45/06 , C07K14/54 , C07K2319/20 , C07K2319/31
摘要： The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
摘要翻译： 本发明涉及与母体白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。 本发明还涉及包含所述变体白蛋白的融合多肽和缀合物。
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