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公开(公告)号：US20090221608A1
公开(公告)日：2009-09-03
申请号：US12182977
申请日：2008-07-30
申请人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
发明人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
IPC分类号： A61K31/506 , C07D401/14 , A61K31/496 , A61P35/00
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其合成及其作为Raf抑制剂的用途。
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公开(公告)号：US07179918B2
公开(公告)日：2007-02-20
申请号：US10166979
申请日：2002-06-11
申请人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula
发明人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula
IPC分类号： C07D207/16 , C07D221/02
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
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3.发明授权Inhibitors of Hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07151105B2
公开(公告)日：2006-12-19
申请号：US11204269
申请日：2005-08-15
IPC分类号： A61K31/519 , A61K31/35 , A01N43/90 , A01N43/16 , C07D487/00
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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公开(公告)号：US07115658B2
公开(公告)日：2006-10-03
申请号：US10434702
申请日：2003-05-09
申请人： Allen J. Borchardt , Peter Scott Dragovich , Javier Gonzalez , Tanya Michelle Jewell , Hui Li , Maria Angelica Linton , John Howard Tatlock , Ru Zhou , Thomas Jay Prins , Melwyn A. Abreo
发明人： Allen J. Borchardt , Peter Scott Dragovich , Javier Gonzalez , Tanya Michelle Jewell , Hui Li , Maria Angelica Linton , John Howard Tatlock , Ru Zhou , Thomas Jay Prins , Melwyn A. Abreo
IPC分类号： A61K31/351
CPC分类号： C07D405/06 , C07D309/32 , C07D405/12 , C07D407/06 , C07D413/12 , C07D417/06 , C07D487/04
摘要： Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
摘要翻译： 式I化合物为丙型肝炎病毒（HCV）RNA依赖性RNA聚合酶（RdRp）抑制剂，可用于丙型肝炎病毒感染者的治疗和预防性治疗
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5.发明授权Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation 失效化合物，药物组合物和刺激神经元生长和伸长的方法公开(公告)号：US06630472B1
公开(公告)日：2003-10-07
申请号：US09356240
申请日：1999-07-16
申请人： Susumu Katoh , Hiroshi Kawakami , Hiroki Tada , Maria Angelica Linton , Vincent Kalish , John Howard Tatlock , Jesus Ernesto Villafranca
发明人： Susumu Katoh , Hiroshi Kawakami , Hiroki Tada , Maria Angelica Linton , Vincent Kalish , John Howard Tatlock , Jesus Ernesto Villafranca
IPC分类号： C07D47118
CPC分类号： C07D471/08
摘要： Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic azaamide nucleus. Pharmaceutical compositions containing such compounds help stimulate the outgrowth of neurites in nerve cells and augmenting nerve regeneration. Methods of treating nerve cells with such compositions are useful to promote repair of neuronal damage caused by disease and physical trauma.
摘要翻译： 描述了抑制FK-506结合蛋白（FKBP）的肽基 - 脯氨酰异构酶（旋转异构酶）酶活性的化合物和包含这些化合物的组合物。 FKBP抑制化合物具有双环[3.3.1]，[4.3.1]或多环氮杂酰胺核。 含有这些化合物的药物组合物有助于刺激神经细胞中神经突的生长并增加神经再生。 用这种组合物治疗神经细胞的方法可用于促进由疾病和身体创伤引起的神经元损伤的修复。
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6.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07622605B2
公开(公告)日：2009-11-24
申请号：US11470540
申请日：2006-09-06
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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7.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07148226B2
公开(公告)日：2006-12-12
申请号：US10718337
申请日：2003-11-19
IPC分类号： A61K31/519
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上 这里。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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公开(公告)号：US07772246B2
公开(公告)日：2010-08-10
申请号：US12182977
申请日：2008-07-30
申请人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
发明人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
IPC分类号： A61K31/505
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其合成及其作为Raf抑制剂的用途。
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9.发明申请INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME 失效HEPATITIS C病毒RNA依赖RNA聚合酶的抑制剂及其组合物和治疗公开(公告)号：US20070015764A1
公开(公告)日：2007-01-18
申请号：US11470540
申请日：2006-09-06
申请人： Javier Gonzalez , Tanya Jewell , Hui Li , Angelica Linton , John Tatlock
发明人： Javier Gonzalez , Tanya Jewell , Hui Li , Angelica Linton , John Tatlock
IPC分类号： A61K31/519 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4433 , A61K31/416 , A61K31/4178 , A61K31/427 , A61K31/422 , C07D487/02 , C07D405/02
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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10.发明申请公开(公告)号：US20060122399A1
公开(公告)日：2006-06-08
申请号：US11204269
申请日：2005-08-15
IPC分类号： A61K31/427 , C07D417/02 , C07D413/02 , C07D405/02
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
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