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公开(公告)号：US08748411B2
公开(公告)日：2014-06-10
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
IPC分类号： A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , C07D251/42 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07D229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
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2.发明授权公开(公告)号：US08367620B2
公开(公告)日：2013-02-05
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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3.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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公开(公告)号：US20090215730A1
公开(公告)日：2009-08-27
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gomez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gomez
IPC分类号： A61K31/17 , A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , A61K31/34 , A61K31/27 , A61K31/16 , A61K31/175 , A61K31/13 , C07D251/02 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07C229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
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