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公开(公告)号：US09205128B2
公开(公告)日：2015-12-08
申请号：US13637845
申请日：2011-04-01
申请人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
发明人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
IPC分类号： A61K38/10 , C12N5/0783 , A61K31/713 , A61K31/19 , A61K38/17 , A61K45/06 , A61K31/7105 , A61K31/5575 , C07K14/47 , C12N15/113
CPC分类号： A61K38/10 , A61K31/19 , A61K31/5575 , A61K31/7105 , A61K31/713 , A61K38/1709 , A61K38/1748 , A61K45/06 , C07K14/47 , C07K14/4741 , C12N5/0636 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N2310/14 , C12N2310/531 , C12N2320/31
摘要： The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.
摘要翻译： 本发明描述了通过负面调节或改变细胞骨架，更精确地形成中间细胞骨架细丝的蛋白质来抑制人免疫缺陷病毒（HIV）复制的方法，其中所述蛋白质是波形蛋白和/或角蛋白-10。 通过介入这些蛋白质的结构，人类细胞中病毒的复制被抑制。 本发明还涉及包含肽和/或干扰RNA和/或脂质化合物的试剂的用途，所述试剂产生细胞骨架的负调节或改变以预防或治疗HIV感染。 本发明提供用于改变细胞的细胞骨架/细丝结构的方法和方法，其结果是HIV的人细胞感染被干扰并且甚至可以被完全抑制。 通过减少波形蛋白和/或角蛋白的量（例如通过使用干扰RNA的转录控制）或通过使用破坏细胞骨架的肽来改变细胞骨架。
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公开(公告)号：US08283324B2
公开(公告)日：2012-10-09
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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公开(公告)号：US20130130971A1
公开(公告)日：2013-05-23
申请号：US13637845
申请日：2011-04-01
申请人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
发明人： Celia Berta Fernandez Ortega , Anna Caridys Ramírez Suárez , Dionne Casillas Casanova , Taimi Emelia Paneque Guerrero , Raimundo Ubieta Gómez , Marta Dubed Echevarria , Leonor Margarita Navea Leyva , Lila Rosa Castellanos Serra , Carlos Antonio Duarte Cano , Viviana Falcón Cama , Osvaldo Reyes Acosta
IPC分类号： A61K38/10 , A61K31/713 , A61K31/7105 , A61K38/17 , A61K45/06 , C12N5/0783 , A61K31/19
CPC分类号： A61K38/10 , A61K31/19 , A61K31/5575 , A61K31/7105 , A61K31/713 , A61K38/1709 , A61K38/1748 , A61K45/06 , C07K14/47 , C07K14/4741 , C12N5/0636 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N2310/14 , C12N2310/531 , C12N2320/31
摘要： The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.
摘要翻译： 本发明描述了通过负面调节或改变细胞骨架，更精确地形成中间细胞骨架细丝的蛋白质来抑制人免疫缺陷病毒（HIV）复制的方法，其中所述蛋白质是波形蛋白和/或角蛋白-10。 通过介入这些蛋白质的结构，人类细胞中病毒的复制被抑制。 本发明还涉及包含肽和/或干扰RNA和/或脂质化合物的试剂的用途，所述试剂产生细胞骨架的负调节或改变以预防或治疗HIV感染。 本发明提供用于改变细胞的细胞骨架/细丝结构的方法和方法，其结果是HIV的人细胞感染被干扰并且甚至可以被完全抑制。 通过减少波形蛋白和/或角蛋白的量（例如通过使用干扰RNA的转录控制）或通过使用破坏细胞骨架的肽来改变细胞骨架。
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公开(公告)号：US20120308661A1
公开(公告)日：2012-12-06
申请号：US13578211
申请日：2011-02-10
申请人： Raimundo Ubieta Gómez , Ana Aguilera Barreto , Eduardo Martínez Díaz , Rolando Paez Meireles , Antonio Sereno Guerra
发明人： Raimundo Ubieta Gómez , Ana Aguilera Barreto , Eduardo Martínez Díaz , Rolando Paez Meireles , Antonio Sereno Guerra
CPC分类号： A61K38/1808 , A61K9/48 , A61K9/50 , A61K9/5026 , A61K9/5078 , A61K47/02 , A61K47/183 , A61K47/38
摘要： The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.
摘要翻译： 本发明包括表皮生长因子和甲硫氨酸颗粒或K 2 S 2 O 7，其包含这些颗粒的胶囊，其制备方法及其用于治疗溃疡性结肠炎。
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5.发明申请FORMULATION OF HEPATITIS B VIRUS ANTIGENS FOR CELLULAR STIMULATION FOLLOWED BY THERAPEUTIC IMMUNIZATION 审中-公开乙型肝炎病毒抗原的制备用于治疗性免疫后细胞刺激公开(公告)号：US20120308615A1
公开(公告)日：2012-12-06
申请号：US13498842
申请日：2010-09-28
申请人： Julio César Aguilar Rubido , Yadira Lobaina Mato , Dunia Hernández Inguanzo , Heidy Trujillo Pérez , Freya de los Milagros Freyre Almeida , Verena Lucila Muzio González , Eduardo Pénton Arias , Sonia Gonzalez Blanco , Raimundo Ubieta Gómez , Gerardo Enrique Guillén Nieto , Luis Saturnino Herrera Martinez
发明人： Julio César Aguilar Rubido , Yadira Lobaina Mato , Dunia Hernández Inguanzo , Heidy Trujillo Pérez , Freya de los Milagros Freyre Almeida , Verena Lucila Muzio González , Eduardo Pénton Arias , Sonia Gonzalez Blanco , Raimundo Ubieta Gómez , Gerardo Enrique Guillén Nieto , Luis Saturnino Herrera Martinez
IPC分类号： A61K39/29 , A61P31/14 , C12N5/0781 , C12N5/0786 , C12N5/0784 , A61K9/14 , C12N5/078
CPC分类号： A61K9/145 , A61K9/10 , A61K39/12 , A61K39/292 , A61K2039/5158 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , C12N2730/10134
摘要： The present invention is related with the field of the therapeutic immunization, specifically with the employment of a new formulation of antigens of the Hepatitis B Virus (HBV) for the cellular stimulation. The formulation is formed by the surface antigens (HBsAg) precipitated in suspension and the nucleocapsid (HBcAg) of the HBV. The formulation contains these antigens like suspended particles of sizes less than 500 nm and higher than 500 nm, in a mixture where the proportion among the particles of the mentioned sizes is among 50%-50% and 80%-20%, respectively. The selection of a range of sizes of particles allows that the levels of stimulation of several cellular types are maximized. Additionally, a cellular stimulation method is described with this formulation, and the later passive immunization of patients with chronic Hepatitis B, based on the maximum stimulation in vivo or in vitro using heterologous or autologous cells (dendritic cells, B cells and macrophages). The cells stimulated with this formulation are transferred to patients chronically infected with the HBV.
摘要翻译： 本发明涉及治疗性免疫领域，特别是使用乙型肝炎病毒（HBV）抗原的新配方用于细胞刺激。 该制剂由悬浮液中沉淀的表面抗原（HBsAg）和HBV的核衣壳（HBcAg）形成。 在上述尺寸的颗粒中的比例分别为50％-50％至80％-20％的混合物中，该制剂含有这些抗原，如尺寸小于500nm且高于500nm的悬浮颗粒。 颗粒尺寸范围的选择使得几种细胞类型的刺激水平最大化。 另外，根据体内或体外使用异源或自体细胞（树突状细胞，B细胞和巨噬细胞）的最大刺激，用该配方描述细胞刺激方法，以及慢性乙型肝炎患者随后的被动免疫。 用该制剂刺激的细胞转移到长期感染HBV的患者。
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公开(公告)号：US09205130B2
公开(公告)日：2015-12-08
申请号：US13578211
申请日：2011-02-10
申请人： Raimundo Ubieta Gómez , Ana Aguilera Barreto , Eduardo Martínez Díaz , Rolando Paez Meireles , Antonio Sereno Guerra
发明人： Raimundo Ubieta Gómez , Ana Aguilera Barreto , Eduardo Martínez Díaz , Rolando Paez Meireles , Antonio Sereno Guerra
CPC分类号： A61K38/1808 , A61K9/48 , A61K9/50 , A61K9/5026 , A61K9/5078 , A61K47/02 , A61K47/183 , A61K47/38
摘要： The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.
摘要翻译： 本发明包括表皮生长因子和甲硫氨酸颗粒或K 2 S 2 O 7，其包含这些颗粒的胶囊，其制备方法及其用于治疗溃疡性结肠炎。
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公开(公告)号：US08748411B2
公开(公告)日：2014-06-10
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
IPC分类号： A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , C07D251/42 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07D229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
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