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    Peptide compositions and their use against the hepatitis C virus
    2.
    发明授权
    Peptide compositions and their use against the hepatitis C virus 失效
    肽组合物及其对丙型肝炎病毒的应用

    公开(公告)号：US08080525B2

    公开(公告)日：2011-12-20

    申请号：US12132321

    申请日：2008-06-03

    申请人： Anne Fournillier ,  Nourredine Himoudi ,  Genevieve Inchauspe

    发明人： Anne Fournillier ,  Nourredine Himoudi ,  Genevieve Inchauspe

    IPC分类号： A61K39/02 ,  A61K39/29 ,  A61K39/42 ,  A61P31/00 ,  C07K14/18 ,  C07K14/195 ,  C07K16/10

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/24222

    摘要： Novel peptide compositions are described. In particular, peptide compositions are described which include at least two peptides which are selected from among the following peptides: a peptide A having at least the amino acid sequence of SEQ ID NO 1, a peptide B having at least the amino acid sequence of SEQ ID NO 45, a peptide C having at least the amino acid sequence of SEQ ID NO 127, and a peptide D having at least the amino acid sequence of SEQ ID NO 174. The compositions can be used, in particular, in the preparation of active pharmaceutical compositions against the hepatitis C virus.

    摘要翻译： 描述了新的肽组合物。 特别地，描述了肽组合物，其包括至少两种选自以下肽的肽：至少具有SEQ ID NO 1的氨基酸序列的肽A，至少具有SEQ ID NO 1的氨基酸序列的肽B ID NO 45，至少具有SEQ ID NO 127的氨基酸序列的肽C和至少具有SEQ ID NO 174的氨基酸序列的肽D.该组合物特别可用于制备 针对丙型肝炎病毒的活性药物组合物。

    Anti hepatitis C virus antibody and uses thereof
    3.
    发明授权
    Anti hepatitis C virus antibody and uses thereof 失效
    抗丙型肝炎病毒抗体及其用途

    公开(公告)号：US07507408B2

    公开(公告)日：2009-03-24

    申请号：US10972296

    申请日：2004-10-25

    申请人： Christian Reiter ,  Francois Habersetzer ,  Anne Fournillier ,  Christian Trepo ,  Claude Desgranges ,  Genevieve Inchauspe

    发明人： Christian Reiter ,  Francois Habersetzer ,  Anne Fournillier ,  Christian Trepo ,  Claude Desgranges ,  Genevieve Inchauspe

    IPC分类号： A61K39/29 ,  A61K39/42 ,  A61K39/12 ,  C12Q1/70 ,  G01N35/53

    CPC分类号： G01N33/5767 ,  A61K2039/505 ,  C07K16/109 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

    摘要： Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.

    摘要翻译： 描述了特异性识别HCV糖蛋白E2的构象依赖性表位的新型抗体，并且能够中和E2蛋白与敏感细胞的结合。 此外，提供了由上述抗体识别的抗原和表位以及编码所述抗体的多核苷酸。 还提供了包含所述多核苷酸的载体以及转化的宿主细胞及其在所述抗体的产生中的用途。 此外，提供药物和诊断组合物，其包含任何上述抗体，抗原，表位，多核苷酸，载体或细胞。 进一步描述了上述抗体，抗原，多核苷酸和载体在过继性免疫治疗中的用途，优选用于治疗或预防肝移植期间的HCV感染。

    ANTI-HEPATITIS C VIRUS ANTIBODY AND USES THEREOF
    9.
    发明申请
    ANTI-HEPATITIS C VIRUS ANTIBODY AND USES THEREOF 审中-公开
    抗生素C病毒抗体及其用途

    公开(公告)号：US20090104188A1

    公开(公告)日：2009-04-23

    申请号：US12207460

    申请日：2008-09-09

    申请人： Christian Reiter ,  Francois Habersetzer ,  Anne Fournillier ,  Christian Trepo ,  Claude Desgranges ,  Genevieve Inchauspe

    发明人： Christian Reiter ,  Francois Habersetzer ,  Anne Fournillier ,  Christian Trepo ,  Claude Desgranges ,  Genevieve Inchauspe

    IPC分类号： A61K39/395

    CPC分类号： G01N33/5767 ,  A61K2039/505 ,  C07K16/109 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

    摘要： Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable of neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.

    摘要翻译： 描述了特异性识别HCV糖蛋白E2的构象依赖性表位并能够中和E2蛋白与敏感细胞的结合的新型抗体。 此外，提供了由上述抗体识别的抗原和表位以及编码所述抗体的多核苷酸。 还提供了包含所述多核苷酸的载体以及转化的宿主细胞及其在所述抗体的产生中的用途。 此外，提供药物和诊断组合物，其包含任何上述抗体，抗原，表位，多核苷酸，载体或细胞。 进一步描述了上述抗体，抗原，多核苷酸和载体在过继性免疫治疗中的用途，优选用于治疗或预防肝移植期间的HCV感染。