Method for producing L-cystine by fermentation under controlled oxygen saturation
    1.
    发明授权
    Method for producing L-cystine by fermentation under controlled oxygen saturation 有权
    在受控氧饱和度下通过发酵生产L-胱氨酸的方法

    公开(公告)号:US09074230B2

    公开(公告)日:2015-07-07

    申请号:US14116049

    申请日:2012-05-04

    IPC分类号: C12P13/12

    CPC分类号: C12P13/12

    摘要: The invention relates to a method for producing L-cystine by fermenting a microorganism strain in a fermentation medium, in which method L-cystine is precipitated in an amount of at least 70% relative to the total cysteine, characterized in that the O2 saturation of the fermentation medium is kept at least at 1% and at most at 40±3% during the formation of L-cystine.

    摘要翻译: 本发明涉及通过在发酵培养基中发酵微生物菌株来生产L-胱氨酸的方法,其中L-胱氨酸相对于总半胱氨酸以至少70%的量沉淀,其特征在于,O 2饱和度 发酵培养基在L-胱氨酸的形成过程中保持在至少1%,最多为40±3%。

    METHOD FOR PRODUCTION OF NATURAL L-CYSTEINE BY FERMENTATION
    2.
    发明申请
    METHOD FOR PRODUCTION OF NATURAL L-CYSTEINE BY FERMENTATION 有权
    通过发酵生产天然L-酪氨酸的方法

    公开(公告)号:US20140141474A1

    公开(公告)日:2014-05-22

    申请号:US14127365

    申请日:2012-06-25

    IPC分类号: C12P13/12 C12P17/14

    CPC分类号: C12P13/12 C12P17/14

    摘要: A method for the production of natural L-cysteine by fermentation in a production fermenter in which a microorganism strain is cultured in a fermentation medium, characterized in that the fraction of the compounds L-cysteine, L-cystine and thiazolidine in the fermentation medium is controlled in a targeted manner by an iron concentration of a maximum of 8 mg/l in the fermentation medium.

    摘要翻译: 在发酵培养基中培养微生物菌株的生产发酵罐中通过发酵生产天然L-半胱氨酸的方法,其特征在于发酵培养基中L-半胱氨酸,L-胱氨酸和噻唑烷化合物的分数为 通过在发酵培养基中最大浓度为8mg / l的铁浓度以目标方式进行控制。

    METHOD FOR PRODUCING L-CYSTINE BY FERMENTATION UNDER CONTROLLED OXYGEN SATURATION
    3.
    发明申请
    METHOD FOR PRODUCING L-CYSTINE BY FERMENTATION UNDER CONTROLLED OXYGEN SATURATION 有权
    通过控制氧气饱和下发酵生产L-儿茶素的方法

    公开(公告)号:US20140080186A1

    公开(公告)日:2014-03-20

    申请号:US14116049

    申请日:2012-05-04

    IPC分类号: C12P13/12

    CPC分类号: C12P13/12

    摘要: The invention relates to a method for producing L-cystine by fermenting a microorganism strain in a fermentation medium, in which method L-cystine is precipitated in an amount of at least 70% relative to the total cysteine, characterized in that the O2 saturation of the fermentation medium is kept at least at 1% and at most at 40±3% during the formation of L-cystine.

    摘要翻译: 本发明涉及通过在发酵培养基中发酵微生物菌株来生产L-胱氨酸的方法,其中L-胱氨酸相对于总半胱氨酸以至少70%的量沉淀,其特征在于,O 2饱和度 发酵培养基在L-胱氨酸的形成过程中保持在至少1%,最多为40±3%。

    Fungicidal 4-monohaloacetoacetoacetanilides
    5.
    发明授权
    Fungicidal 4-monohaloacetoacetoacetanilides 失效
    杀真菌剂4-单卤代乙酰乙酰乙酰替苯胺

    公开(公告)号:US4902715A

    公开(公告)日:1990-02-20

    申请号:US233199

    申请日:1988-06-27

    IPC分类号: A01N37/42 A01N37/46

    CPC分类号: A01N37/42 A01N37/46

    摘要: Compounds of the formula ##STR1## wherein X is a halogen atom, R the same or different substituents in any desired position of the benzene ring, namely, halogen atoms, C.sub.1 -C.sub.3 -alkyl groups, trifluoromethyl groups or cyano groups and n a whole number with a value of 1, 2 or 3, are fungicidally active.

    摘要翻译: PCT No.PCT / EP87 / 00564 Sec。 371日期:1988年6月27日第 102(e)日期1988年6月27日PCT提交1987年10月1日PCT公布。 出版物WO88 / 03132 日期:1988年5月5日。式(I)的化合物其中X是卤素原子,R是苯环的任何所需位置中相同或不同的取代基,即卤素原子,C 1 -C 3 - 烷基, 三氟甲基或氰基,na值为1,2或3的全数为杀真菌活性。

    3-halosuccinimides
    6.
    发明授权
    3-halosuccinimides 失效
    3-卤代琥珀酰亚胺

    公开(公告)号:US4900840A

    公开(公告)日:1990-02-13

    申请号:US240763

    申请日:1988-06-15

    IPC分类号: C07D207/40 C07D207/416

    CPC分类号: C07D207/416

    摘要: The invention concerns fungicidal compounds of the formula ##STR1## wherein R signifies a chlorine, bromine or iodine atom, n 0, 1, 2 or 3 and X, X', Y and Z have the meanings given in the description.

    摘要翻译: PCT No.PCT / EP87 / 00563 Sec。 371日期1988年6月15日第 102(e)日期1988年6月15日PCT提交1987年10月1日PCT公布。 出版物WO88 / 02747 日期:1988年4月21日。本发明涉及式(I)的杀真菌化合物,其中R表示氯,溴或碘原子,n 0,1,2或3,X,X',Y和Z具有 说明中给出的含义。

    Substituted phenylacetic acid iodopropargyl esters, biocidal agents
containing same and process for manufacturing same
    7.
    发明授权
    Substituted phenylacetic acid iodopropargyl esters, biocidal agents containing same and process for manufacturing same 失效
    取代苯乙酸碘代炔丙酯,含有其的杀生物剂及其制造方法

    公开(公告)号:US4639541A

    公开(公告)日:1987-01-27

    申请号:US727027

    申请日:1985-04-25

    CPC分类号: C07C69/65

    摘要: Substituted phenylactic acid iodopropargyl ester compounds of the general formula: ##STR1## in which R may represent hydrogen, fluorine, chlorine, bromine, iodine, methoxy, 1-imidazolyl or 1,2,4-triazolyl, X represents one or more of the same or different substituents selected from fluorine, chlorine, bromine, iodine, cyano, nitro, carboxyl, an alkyl having from 1 to 12 carbon atoms, an alkoxy having from 1 to 12 carbon atoms, a cycloalkyl having from 3 to 6 carbon atoms, formyl, acetyl, propionyl, benzoyl, phenylsulfonyl, phenyl, phenoxy, and substituted phenyl and phenoxy groups having from 1 to 3 substituents selected from fluorine, chlorine, bromine, nitro, methyl or methoxy, and n is an integer from 1 to 5 and may be zero provided that R does not represent hydrogen. The invention also relates to a process of making the compounds, which are effective ingredients of biocidal agents.

    摘要翻译: 取代的苯甲酸碘代炔丙基酯化合物,其通式为:其中R可以代表氢,氟,氯,溴,碘,甲氧基,1-咪唑基或1,2,4-三唑基,X代表一个或多个 相同或不同的选自氟,氯,溴,碘,氰基,硝基,羧基,具有1至12个碳原子的烷基,具有1至12个碳原子的烷氧基,具有3至6个碳原子的环烷基, 甲酰基,乙酰基,丙酰基,苯甲酰基,苯基磺酰基,苯基,苯氧基和取代的苯基和具有1至3个选自氟,氯,溴,硝基,甲基或甲氧基的取代基的苯氧基,n为1至5的整数, 可以为零,条件是R不表示氢。 本发明还涉及制备作为杀生物剂的有效成分的化合物的方法。

    PROCESS FOR THE FERMENTATIVE PRODUCTION OF PROTEINS
    8.
    发明申请
    PROCESS FOR THE FERMENTATIVE PRODUCTION OF PROTEINS 审中-公开
    蛋白质发酵生产工艺

    公开(公告)号:US20080076158A1

    公开(公告)日:2008-03-27

    申请号:US11859350

    申请日:2007-09-21

    IPC分类号: C12P21/04 C12N1/21

    摘要: The present invention relates to a process for producing a heterologous protein by means of an E. coli strain in a fermentation medium, in which an E. coli strain which has a mutation in the lpp gene or in the promoter region of the lpp gene, and contains a gene coding for a heterologous protein which is functionally linked to a signal sequence coding for a signal peptide, is fermented on an industrial scale in the fermentation medium, with the E. coli strain secreting the heterologous protein into the fermentation medium, and the protein being removed from the fermentation medium, wherein the heterologous protein comprises more than 70 amino acids.

    摘要翻译: 本发明涉及在发酵培养基中通过大肠杆菌菌株生产异源蛋白的方法,其中在lpp基因中或在lpp基因的启动子区域具有突变的大肠杆菌菌株, 并且包含编码与编码信号肽的信号序列功能性相关的异源蛋白质的基因,在发酵培养基中以工业规模发酵,将分泌异源蛋白质的大肠杆菌菌株发酵到发酵培养基中,以及 所述蛋白质从所述发酵培养基中除去,其中所述异源蛋白质包含超过70个氨基酸。

    Method for production of natural L-cysteine by fermentation
    9.
    发明授权
    Method for production of natural L-cysteine by fermentation 有权
    通过发酵生产天然L-半胱氨酸的方法

    公开(公告)号:US08802399B2

    公开(公告)日:2014-08-12

    申请号:US14127365

    申请日:2012-06-25

    IPC分类号: C12P13/12 C12P17/14

    CPC分类号: C12P13/12 C12P17/14

    摘要: A method for the production of natural L-cysteine by fermentation in a production fermenter in which a microorganism strain is cultured in a fermentation medium, characterized in that the fraction of the compounds L-cysteine, L-cystine and thiazolidine in the fermentation medium is controlled in a targeted manner by an iron concentration of a maximum of 8 mg/l in the fermentation medium.

    摘要翻译: 在发酵培养基中培养微生物菌株的生产发酵罐中通过发酵生产天然L-半胱氨酸的方法,其特征在于发酵培养基中L-半胱氨酸,L-胱氨酸和噻唑烷化合物的分数为 通过在发酵培养基中最大浓度为8mg / l的铁浓度以目标方式进行控制。

    Method for the enzymatic production of chiral 1-acylated 1,2-diols
    10.
    发明申请
    Method for the enzymatic production of chiral 1-acylated 1,2-diols 审中-公开
    手性1-酰化1,2-二醇的酶促生产方法

    公开(公告)号:US20070042475A1

    公开(公告)日:2007-02-22

    申请号:US11504288

    申请日:2006-08-15

    IPC分类号: C12P7/62 C12N9/02

    CPC分类号: C12P7/62

    摘要: A method for the production of a chiral compound of the formula (I), R1 being identical or different and being H or an organic radical, where a biotransformation composition comprising a compound of the formula (II), an oxidoreductase, a redox cofactor and a cosubstrate are reacted forming the chiral compound of the formula (I) which is subsequently isolated.

    摘要翻译: 制备式(I)的手性化合物的方法相同或不同,为H或有机基团,其中包含式(II)化合物的生物转化组合物, ,氧化还原酶,氧化还原辅因子和顺碱反应,形成随后分离的式(I)的手性化合物。