利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.013 秒)

    COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
    1.
    发明申请
    COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
    用于促进骨髓再生和补充的复合植入物及其制备和使用方法

    公开(公告)号：US20090269386A1

    公开(公告)日：2009-10-29

    申请号：US12432830

    申请日：2009-04-30

    申请人： YUVAL ZUBERY ,  ARIE GOLDLUST ,  THOMAS BAYER ,  ERAN NIR

    发明人： YUVAL ZUBERY ,  ARIE GOLDLUST ,  THOMAS BAYER ,  ERAN NIR

    IPC分类号： A61K9/00 ,  A61P19/00

    CPC分类号： A61L27/56 ,  A61L27/48 ,  C08L89/06

    摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.

    摘要翻译： 用还原糖交联的基于胶原的基质用于制备复合基质，植入物和支架。 复合基质可以具有至少两层，包括不同密度的还原糖交联的胶原基质。 复合基质可用于骨再生和/或增强应用。 包括糖基化和/或还原糖交联胶原的支架显示改善的对细胞增殖和/或生长和/或分化的支持。 复合基质的更密集的胶原基质可能具有起初作为细胞屏障起作用的双重作用，并且此后作为骨化支持层起作用。 复合基质，植入物和支架可以使用不同的胶原类型和胶原混合物和使用还原糖或还原糖的混合物交联胶原来制备。 复合基质，植入物和支架可以包括添加剂和/或活细胞。

    COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
    4.
    发明申请
    COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
    用于促进骨髓再生和补充的复合植入物及其制备和使用方法

    公开(公告)号：US20080026032A1

    公开(公告)日：2008-01-31

    申请号：US11829111

    申请日：2007-07-27

    申请人： Yuval ZUBERY ,  Arie Goldlust ,  Thomas Bayer ,  Eran Nir

    发明人： Yuval ZUBERY ,  Arie Goldlust ,  Thomas Bayer ,  Eran Nir

    IPC分类号： A61F2/00 ,  A61K38/00 ,  A61P19/00

    CPC分类号： A61L27/56 ,  A61L27/48 ,  C08L89/06

    摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.

    摘要翻译： 用还原糖交联的基于胶原的基质用于制备复合基质，植入物和支架。 复合基质可以具有至少两层，包括不同密度的还原糖交联的胶原基质。 复合基质可用于骨再生和/或增强应用。 包括糖基化和/或还原糖交联胶原的支架显示改善的对细胞增殖和/或生长和/或分化的支持。 复合基质的更密集的胶原基质可能具有起初作为细胞屏障起作用的双重作用，并且此后作为骨化支持层起作用。 复合基质，植入物和支架可以使用不同的胶原类型和胶原混合物和使用还原糖或还原糖的混合物交联胶原来制备。 复合基质，植入物和支架可以包括添加剂和/或活细胞。

    COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
    5.
    发明申请
    COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开

    公开(公告)号：US20090269387A1

    公开(公告)日：2009-10-29

    申请号：US12432833

    申请日：2009-04-30

    申请人： Yuval Zubery ,  Arie Goldlust ,  Thomas Bayer ,  Eran Nir

    发明人： Yuval Zubery ,  Arie Goldlust ,  Thomas Bayer ,  Eran Nir

    IPC分类号： A61F2/00 ,  A61K35/00 ,  A61K35/32 ,  A61K35/30 ,  A61P19/00

    CPC分类号： A61L27/56 ,  A61L27/48 ,  C08L89/06

    摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.

    Cross-linked polysacharide and protein matrices and methods for their preparation
    6.
    发明申请
    Cross-linked polysacharide and protein matrices and methods for their preparation 审中-公开
    交联多糖和蛋白质基质及其制备方法

    公开(公告)号：US20070053987A1

    公开(公告)日：2007-03-08

    申请号：US11513345

    申请日：2006-08-31

    申请人： Thomas Bayer ,  Arie Goldlust

    发明人： Thomas Bayer ,  Arie Goldlust

    IPC分类号： A61K48/00 ,  A61K38/22 ,  A61K38/18 ,  A61K38/14 ,  C07H5/06 ,  C08B37/00 ,  A61K9/14

    CPC分类号： A61K38/39 ,  A61K9/146 ,  A61K47/61 ,  A61L27/20 ,  C07H5/06 ,  C08B37/003 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0081 ,  C08H1/00 ,  C08H1/06

    摘要： Methods for preparing cross-linked polysaccharide matrices by cross-linking one or more amino group containing polysaccharides or amino-functionalized polysaccharides with reducing sugars and/or reducing sugar derivatives. The resulting matrices may include polysaccharide matrices and composite cross-linked matrices including polysaccharides cross-linked with proteins and/or polypeptides. Additives and/or cells may also be included in or embedded within the matrices. Various different solvent systems and reducing sugar cross-linkers for performing the cross-linking are described. The resulting matrices exhibit various different physical, chemical and biological properties.

    摘要翻译： 通过用还原糖和/或还原糖衍生物交联一个或多个含氨基的多糖或氨基官能化多糖来制备交联多糖基质的方法。 所得到的基质可以包括多糖基质和包含与蛋白质和/或多肽交联的多糖的复合交联基质。 添加剂和/或细胞也可以包括在基质中或嵌入在基质中。 描述了用于进行交联的各种不同的溶剂体系和还原糖交联剂。 所得到的基质表现出各种不同的物理，化学和生物学特性。