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公开(公告)号：US08288520B2
公开(公告)日：2012-10-16
申请号：US12605540
申请日：2009-10-26
申请人： Paul Eder , Eric Payne , Irina Nazarenko , Suganthi Ramachandran , Arvind Virmani , Laura Bell
发明人： Paul Eder , Eric Payne , Irina Nazarenko , Suganthi Ramachandran , Arvind Virmani , Laura Bell
CPC分类号： C12Q1/6804 , C12Q1/708 , C12Q2527/125 , C12Q2527/153
摘要： The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
摘要翻译： 本发明包括提供用于检测样品中靶核酸分子的存在的快速可靠结果的方法。
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2.发明授权公开(公告)号：US09689047B2
公开(公告)日：2017-06-27
申请号：US13015915
申请日：2011-01-28
申请人： Dominic O'Neil , Irina Nazarenko , Holly Basham , Arvind Virmani , Shiuli Agarwal , Mridula Shukla
发明人： Dominic O'Neil , Irina Nazarenko , Holly Basham , Arvind Virmani , Shiuli Agarwal , Mridula Shukla
CPC分类号： C12Q1/708 , C12Q1/6804 , C12Q1/6806 , C12Q2565/531 , C12Q2535/131
摘要： Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step using two separate sequence-specific polynucleotide probes. Also provided are nucleic acids comprising SEQ ID NO: 1 to SEQ ID NO: 727 and nucleic acid probes and probe sets comprising the same.
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公开(公告)号：US08735564B2
公开(公告)日：2014-05-27
申请号：US13616899
申请日：2012-09-14
申请人： Paul Eder , Eric Payne , Irina Nazarenko , Suganthi Ramachandran , Arvind Virmani , Laura Bell
发明人： Paul Eder , Eric Payne , Irina Nazarenko , Suganthi Ramachandran , Arvind Virmani , Laura Bell
CPC分类号： C12Q1/6804 , C12Q1/708 , C12Q2527/125 , C12Q2527/153
摘要： The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
摘要翻译： 本发明包括提供用于检测样品中靶核酸分子的存在的快速可靠结果的方法。
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公开(公告)号：US20130011830A1
公开(公告)日：2013-01-10
申请号：US13616899
申请日：2012-09-14
申请人： Paul EDER , Eric PAYNE , Irina NAZARENKO , Suganthi RAMACHANDRAN , Arvind VIRMANI , Laura BELL
发明人： Paul EDER , Eric PAYNE , Irina NAZARENKO , Suganthi RAMACHANDRAN , Arvind VIRMANI , Laura BELL
IPC分类号： G01N33/566 , G01N21/76 , G01N33/569
CPC分类号： C12Q1/6804 , C12Q1/708 , C12Q2527/125 , C12Q2527/153
摘要： The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
摘要翻译： 本发明包括提供用于检测样品中靶核酸分子的存在的快速可靠结果的方法。
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5.发明申请METHODS, COMPOSITIONS, AND KITS FOR RECOVERY OF NUCLEIC ACIDS OR PROTEINS FROM FIXED TISSUE SAMPLES 有权用于从固定组织样品中回收核酸或蛋白质的方法，组合物和工具公开(公告)号：US20110196146A1
公开(公告)日：2011-08-11
申请号：US12984391
申请日：2011-01-04
申请人： Yuri KHRIPIN , Arvind Virmani , Lori Kobayashi
发明人： Yuri KHRIPIN , Arvind Virmani , Lori Kobayashi
CPC分类号： C12N15/1003
摘要： Methods and materials for improving nucleic acid or protein recovery from samples preserved in liquid cytological preservative solutions by utilizing scavenging agents, such as hydrazine- and hydrazide-containing compounds, are provided. Lysis solutions comprising hydrazine- and hydrazide-containing compounds and kits comprising the same are also provided.
摘要翻译： 提供了通过使用清除剂（例如含肼和酰肼的化合物）来改善保存在液体细胞学防腐剂溶液中的样品的核酸或蛋白质回收的方法和材料。 还提供了含有肼和酰肼的化合物和包含其的试剂盒的裂解溶液。
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公开(公告)号：US20100105060A1
公开(公告)日：2010-04-29
申请号：US12605605
申请日：2009-10-26
申请人： Paul EDER , Eric PAYNE , Irina NAZARENKO , Suganthi Ramachandran , Arvind VIRMANI , Laura BELL
发明人： Paul EDER , Eric PAYNE , Irina NAZARENKO , Suganthi Ramachandran , Arvind VIRMANI , Laura BELL
CPC分类号： C12Q1/6804 , C12Q1/708 , C12Q2527/125 , C12Q2527/153
摘要： The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
摘要翻译： 本发明包括提供用于检测样品中靶核酸分子的存在的快速可靠结果的方法。
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7.发明授权Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples 有权用于从固定组织样品中回收核酸或蛋白质的方法，组合物和试剂盒公开(公告)号：US08722328B2
公开(公告)日：2014-05-13
申请号：US12984391
申请日：2011-01-04
申请人： Yuri Khripin , Arvind Virmani , Lori Kobayashi
发明人： Yuri Khripin , Arvind Virmani , Lori Kobayashi
CPC分类号： C12N15/1003
摘要： Methods and materials for improving nucleic acid or protein recovery from samples preserved in liquid cytological preservative solutions by utilizing scavenging agents, such as hydrazine- and hydrazide-containing compounds, are provided. Lysis solutions comprising hydrazine- and hydrazide-containing compounds and kits comprising the same are also provided.
摘要翻译： 提供了通过使用清除剂（例如含肼和酰肼的化合物）来改善保存在液体细胞学防腐剂溶液中的样品的核酸或蛋白质回收的方法和材料。 还提供了含有肼和酰肼的化合物和包含其的试剂盒的裂解溶液。
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8.发明申请METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC PURIFICATION AND MULTIPLEX ANALYSIS OF NUCLEIC ACIDS 有权核酸的序列特异性纯化和多重分析的方法和组合物公开(公告)号：US20110217705A1
公开(公告)日：2011-09-08
申请号：US13015915
申请日：2011-01-28
CPC分类号： C12Q1/708 , C12Q1/6804 , C12Q1/6806 , C12Q2565/531 , C12Q2535/131
摘要： Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step using two separate sequence-specific polynucleotide probes. Also provided are nucleic acids comprising SEQ ID NO: 1 to SEQ ID NO: 727 and nucleic acid probes and probe sets comprising the same.
摘要翻译： 提供了用于确定样品中至少一种核酸存在的方法和材料，所述方法包括（1）使用序列特异性杂交捕获的纯化步骤; （2）扩增步骤; 和（3）使用两个单独的序列特异性多核苷酸探针的检测步骤。 还提供了包含SEQ ID NO：1至SEQ ID NO：727的核酸和包含其的核酸探针和探针组。
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9.发明授权Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids 有权用于核酸序列特异性纯化和多重分析的方法和组合物公开(公告)号：US09422593B2
公开(公告)日：2016-08-23
申请号：US13110660
申请日：2011-05-18
申请人： Thomas Rothmann , Irina Nazarenko , Dominic O'Neil , Arvind Virmani , Brian Lowe , Shiuli Agarwal , Holly Basham
发明人： Thomas Rothmann , Irina Nazarenko , Dominic O'Neil , Arvind Virmani , Brian Lowe , Shiuli Agarwal , Holly Basham
CPC分类号： C12Q1/6806 , C12Q1/689 , Y02A50/52 , Y02A50/59 , Y02A50/60 , C12Q2537/143 , C12Q2563/107 , C12Q2565/518
摘要： Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step comprising contacting the target nucleic acid with a plurality of detectably labeled nucleic acid detection probes, wherein each (a) bears a different detectable label from the other detection probes, and/or (b) has a different melting temperature from probes bearing the same detectable label. Also disclosed are compositions and kits for use in such a method.
摘要翻译： 提供了用于确定样品中至少一种核酸存在的方法和材料，所述方法包括（1）使用序列特异性杂交捕获的纯化步骤; （2）扩增步骤; （3）检测步骤，包括使目标核酸与多个可检测标记的核酸检测探针接触，其中每个（a）与其它检测探针具有不同的可检测标记，和/或（b）具有不同的熔点 带有相同可检测标签的探针的温度。 也公开了用于这种方法的组合物和试剂盒。
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公开(公告)号：US08877436B2
公开(公告)日：2014-11-04
申请号：US12605605
申请日：2009-10-26
申请人： Paul Eder , Eric Payne , Irina Nazarenko , Suganthi Ramachandran , Arvind Virmani , Laura Bell
发明人： Paul Eder , Eric Payne , Irina Nazarenko , Suganthi Ramachandran , Arvind Virmani , Laura Bell
CPC分类号： C12Q1/6804 , C12Q1/708 , C12Q2527/125 , C12Q2527/153
摘要： The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.
摘要翻译： 本发明包括提供用于检测样品中靶核酸分子的存在的快速可靠结果的方法。
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